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Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances

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Abstract

In the past five decades, red blood cells (RBCs) have been extensively explored as drug delivery systems due to their distinguishing potential in modulating the pharmacokinetic, pharmacodynamics, and biological activity of carried payloads. The extensive interests in RBC-mediated drug delivery technologies are in part derived from RBCs’ unique biological features such as long circulation time, wide access to many tissues in the body, and low immunogenicity. Owing to these outstanding properties, a large body of efforts have led to the development of various RBC-inspired strategies to enable precise drug delivery with enhanced therapeutic efficacy and reduced off-target toxicity. In this review, we discuss emerging concepts and new advances in such RBC-inspired strategies, including native RBCs, ghost RBCs, RBC-mimetic nanoparticles, and RBC-derived extracellular vesicles, for drug delivery.

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Acknowledgements

ZZ acknowledge support from College of Pharmacy at University of Illinois Chicago.

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  1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, IL, 60612, USA

    Endong Zhang, Philana Phan, Hanan Ahmed Algarni & Zongmin Zhao

  2. Translational Oncology Program, University of Illinois Cancer Center, Chicago, IL, 60612, USA

    Zongmin Zhao

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Zhang, E., Phan, P., Algarni, H.A. et al. Red Blood Cell Inspired Strategies for Drug Delivery: Emerging Concepts and New Advances. Pharm Res 39, 2673–2698 (2022). https://doi.org/10.1007/s11095-022-03328-5

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