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Novel Deep Eutectic Solvent–Hydrogel Systems for Synergistic Transdermal Delivery of Chinese Herb Medicine and Local Treatments for Rheumatoid Arthritis

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Abstract

In this study, a novel hydrogel system incorporating an amino acid–based deep eutectic solvent (DES) was prepared, and the skin-permeation enhancement of traditional Chinese herb medicine was evaluated using “sanwujiaowan” extract as the model formula. Briefly, a DES–extract complex was constructed by co-heating the herb formula extracts with the amino acid as the hydrogen receptor and citric acid as the hydrogen donor. The DES–extract complex demonstrated excellent dissolution and skin permeability of the complicated ingredients in the extracts. Consequently, the DES–extract complex was introduced to a hydrogel system, which showed better mechanical properties and viscoelasticity performance. Using a collagen-induced arthritis rat model, the DES–hydrogels exerted an enhanced therapeutic effect that significantly reduced the inflammatory response with systemic toxicity of the extracts. Therefore, our work suggests a novel strategy for synergistic transdermal delivery of Chinese herb medicine and local treatments for rheumatoid arthritis.

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Acknowledgements and Disclosures

This work was supported by the National Natural Science Foundation of China (81760642; 82060645), the Key Natural Science Foundation of Yunnan Province (202002AA100004-2, 202102AA310045, 202002AA1000056, and 202101AT070099). All authors declare no conflicts of interest.

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Author notes

  1. Suyun Xiao and Liyun Wang contributed equally to the work.

Authors and Affiliations

  1. School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People’s Republic of China

    Suyun Xiao, Liyun Wang, Xiuming Cui & Chengxiao Wang

  2. Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan, Province, Kunming, 650500, China

    Suyun Xiao, Liyun Wang, Xiuming Cui & Chengxiao Wang

  3. School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China

    Wei Han & Liyun Gu

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  1. Suyun Xiao
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Correspondence to Xiuming Cui or Chengxiao Wang.

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Xiao, S., Wang, L., Han, W. et al. Novel Deep Eutectic Solvent–Hydrogel Systems for Synergistic Transdermal Delivery of Chinese Herb Medicine and Local Treatments for Rheumatoid Arthritis. Pharm Res 39, 2431–2446 (2022). https://doi.org/10.1007/s11095-022-03239-5

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