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Preparation of Cinnamon-Coated Cerium Oxide Nanoparticles and Evaluation of their Anticonvulsant Effect in Rats

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Pharmaceutical Chemistry Journal Aims and scope

This study was aimed at evaluating the effects of cinnamon-coated cerium oxide nanoparticles as a new drug for treatring pentylenetetrazole-induced seizures in rats. For this purpose, cerium oxide nanoparticles were prepared, characterized, coated with cinnamon, and evaluated for the anticonvulsant effects upon intraperitoneal injection to mice. The sedative and anxiolytic effects of nanoparticles were examined and the oxidative stress index of brain tissue was determined using a commercial kit. These findings showed that cinnamon-coated cerium oxide nanoparticles at a high dose significantly delayed the latent period of seizrues, decreased anxiety, and suppressed neuronal apoptosis in the rat brain. Results suggest that these nanoparticles possess anticonvulsant activity, produce sedative effect, and exhibit antioxidant properties.

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Authors and Affiliations

  1. Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran

    Fatemeh Mojarrad

  2. Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran

    Asadollah Asadi

  3. Department of Biophysics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran

    Arash Abdolmaleki

  4. Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran

    Sharareh Mirzaee

  5. Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran

    Saber Zahri

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  1. Fatemeh Mojarrad
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  2. Asadollah Asadi
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Correspondence to Arash Abdolmaleki.

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Mojarrad, F., Asadi, A., Abdolmaleki, A. et al. Preparation of Cinnamon-Coated Cerium Oxide Nanoparticles and Evaluation of their Anticonvulsant Effect in Rats. Pharm Chem J 57, 648–655 (2023). https://doi.org/10.1007/s11094-023-02933-x

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  • DOI: https://doi.org/10.1007/s11094-023-02933-x

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