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Extended-Release Tablets of Nitrofurantoin: An Old Antibiotic Carried in a New Formulation

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Pharmaceutical Chemistry Journal Aims and scope

Nitrofurantoin is an old antibiotic currently prescribed to treat urinary tract infections. High dosing frequency causes fluctuations in the drug plasma concentration making less desirable prescription. This work was aimed to overcome these shortcomings by developing extended-release formulations. Tablets were prepared using nitrofurantoin and crosslinked poly(acrylic acid) and hydroxypropyl methylcellulose (HPMC) as hydrophilic polymer matrices. Modified tablets containing HPMC exhibited adequate swelling, erosion, and dissolution profiles and showed potential to decrease the frequency of administrations and reduce fluctuations in the drug plasma concentration. This would result in higher therapeutic effect and increases patient compliance by reducing adverse effects.

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. College of Pharmacy, Institute of Biological Sciences, University of Passo Fundo, Passo Fundo, Rio Grande Do Sul, Brazil

    Charise Dallazem Bertol, Éllen Manica Schonhorst, Natália De Britto Tristacci, Luciana Grazziotin Rossato-Grando & Aline Camilotti Gaio

  2. Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo, Rio Grande Do Sul, Brazil

    Charise Dallazem Bertol

  3. Graduate Program in Bioexperimentation, University of Passo Fundo, Passo Fundo, Rio Grande Do Sul, Brazil

    Luciana Grazziotin Rossato-Grando

  4. College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida, USA

    Samaneh Alaei, Yadollah Omidi & Hamid Omidian

Authors
  1. Charise Dallazem Bertol
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  2. Éllen Manica Schonhorst
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Correspondence to Charise Dallazem Bertol.

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Bertol, C.D., Schonhorst, É.M., Tristacci, N.D.B. et al. Extended-Release Tablets of Nitrofurantoin: An Old Antibiotic Carried in a New Formulation. Pharm Chem J 55, 808–813 (2021). https://doi.org/10.1007/s11094-021-02499-6

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  • DOI: https://doi.org/10.1007/s11094-021-02499-6

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