A kilogram-scale synthesis of fingolimod drug substance was developed using a 30-L pilot setup. The target product was obtained by a four-step procedure in 99.8% purity and 47% overall yield.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 51, No. 6, pp. 38 – 41, June, 2017.
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Balaev, A.N., Busel, A.A. & Fedorov, V.E. Kilogram-Scale Pilot Synthesis of Fingolimod. Pharm Chem J 51, 476–479 (2017). https://doi.org/10.1007/s11094-017-1636-x
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DOI: https://doi.org/10.1007/s11094-017-1636-x