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CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets

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Abstract

Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and treatment. Identifying reliable prognosis biomarkers and treatment targets is crucial to address these challenges. Circular RNA (circRNA) has emerged as a promising research biomarkers and therapeutic targets because of its tissue specificity and conservation. However, the potential role of circRNA in stroke prognosis and treatment remains largely unexplored. This review briefly elucidate the mechanism underlying circRNA’s involvement in stroke pathophysiology. Additionally, this review summarizes the impact of circRNA on different forms of strokes, including ischemic stroke and hemorrhagic stroke. And, this article discusses the positive effects of circRNA on promoting cerebrovascular repair and regeneration, maintaining the integrity of the blood-brain barrier (BBB), and reducing neuronal injury and immune inflammatory response. In conclusion, the significance of circRNA as a potential prognostic biomarker and a viable therapeutic target was underscored.

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Funding

This research was funded by National Natural Science Foundation of China (82171295), and the Sichuan Science and Technology Program (2021YFS0376, 2023YFS0042).

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Authors and Affiliations

  1. School of Clinical Medicine, Southwest Medical University, Luzhou, 646000, China

    Xiao-Ling Chen

  2. Department of Neurology, School of Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China

    Xiao-Ling Chen

  3. Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610072, China9, China

    Quan-Dan Tan, Hong-Wei Deng, Song He & Feng-Kai Mao

  4. School of Public Health, Chengdu Medical College, Chengdu, 610072, China

    Ke-Jie Chen

  5. Brain Health Initiative, The George Institute for Global Health, University of New South Wales, Sydney, 2025, Australia

    Dan-Ni Zheng

  6. School of Biomedical Sciences and Technology, Chengdu Medical College, Chengdu, 610072, China

    Jun-Li Hao & Jie Yang

  7. Institute of Neurology, School of Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China

    Wei-Dong Le

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H.-L.C., Q.-D.T., K.-J.C. and J.Y. contributed to the writing of the manuscript. S.H., F.-K. M. and H.-W.D. conceptualized the review. J.-L.H. drew the images. D.-N.Z. edited languages. W.L and J.Y overviewed and approved this manuscript. All authors contributed to the article and approved the submitted version. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Wei-Dong Le or Jie Yang.

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Chen, XL., Tan, QD., Chen, KJ. et al. CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets. Neurochem Res 49, 557–567 (2024). https://doi.org/10.1007/s11064-023-04077-6

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