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Noise Induced Depression-Like Behavior, Neuroinflammation and Synaptic Plasticity Impairments: The Protective Effects of Luteolin

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Abstract

Noise is a kind of sound that causes agitation and harms human health. Studies have shown that noise can lead to neuroinflammation, damage to synaptic plasticity and altered levels of neurotransmitters that may result in depression. The present study demonstrated that luteolin exerted antidepressant-like effects by improving neuroinflammation in a mouse model of noise-induced depression. Luteolin significantly alleviated noise-induced depression-like behavior. Notably, luteolin treatment not only remarkably ameliorated noise-induced inflammation in the hippocampus and prefrontal cortex, but also increased synapsin. Furthermore, luteolin treatment significantly increased the contents of serum 5-hydroxytryptamine and norepinephrine in noise-induced mice. In sum, luteolin exerts antidepressant effects indepression-like mice caused by noise, which can serve as a potential agent for the treatment of chronic noise-induced depression.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by the Technology Innovation Project for the Special Social Development of Public Health in Xuzhou City (Grant No.KC20168) and the Open Research Project of Research Center of Biochemistry and Molecular Biology Jiangsu Key Laboratory of Brain Disease Bioinformation (Grant No. JSBL201802).

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  1. Yuan Cheng, Xiaoxuan Wang, and Yinghua Yu have contributed equally to this paper.

Authors and Affiliations

  1. Research Center of Biochemistry and Molecular Biology Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China

    Yuan Cheng, Xiaoxuan Wang, Maofang Zhao, Qian Fu & Yilin Song

  2. Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China

    Yinghua Yu

  3. Department of Biophysics, School of Life Sciences, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China

    Yi Liu

  4. Department of Pharmacy, The Ninth People’s Hospital of Suzhou, Suzhou, 215200, Jiangsu, China

    Jingxue Gu

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YL and JG: contributed to the study conception and design. XW, MZ, QF and YS: material preparation, data collection and analysis were performed. YC and YY: the first draft of the manuscript was written, all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Cheng, Y., Wang, X., Yu, Y. et al. Noise Induced Depression-Like Behavior, Neuroinflammation and Synaptic Plasticity Impairments: The Protective Effects of Luteolin. Neurochem Res 47, 3318–3330 (2022). https://doi.org/10.1007/s11064-022-03683-0

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