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Effect of diabetes on efferocytosis process

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Abstract

Diabetes is a complex of genetic, metabolic, and autoimmune disorders that are characterized by hyperglycemia. Elevated apoptotic cell count following defective clearance of dead cells that can cause chronic inflammation is a hallmark of the diabetic wound. Effective dead cell clearance is a prerequisite for rapid inflammation resolution and successful recovery. Efferocytosis is a multistep process in which phagocytes engulf the dead cells. Cell body elimination is of great significance in disease and homeostasis. Recent research has clarified that diabetic wounds have an enhanced load of the apoptotic cell, which is partly attributed to the dysfunction of macrophages in apoptotic clearance at the site of the diabetic wounds. In the current work, we highlight the pathways implicated in efferocytosis, from the diagnosis of apoptotic cells to the phagocytic swallowing and the homeostatic resolution, and explain the possible pathophysiological episodes occurring when the proceeding is abrogated. Also, we describe the last development in the management of inflammation in diabetes wound and future directions of surveillance.

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    Authors and Affiliations

    1. Department of medical biotechnology and nanotechnology, faculty of medicine, Mashhad University of Medical science, Mashhad, Iran

      Ali Mahmoudi

    2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

      Ali Ahmadizad firouzjaei

    3. Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran

      Fatemeh darijani

    4. Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran

      Jamshid Gholizadeh Navashenaq

    5. Department of Medical Genetic, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

      Eskandar Taghizadeh

    6. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

      Majid Darroudi

    7. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

      Majid Darroudi

    8. Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran

      Majid Darroudi

    9. Department of Medical Biotechnology, School of Medicine, Shahid Sadoughi University of Medical Sciences, P.O. Box: 8915173143, Yazd, Iran

      Seyed Mohammad Gheibihayat

    Authors
    1. Ali Mahmoudi
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    2. Ali Ahmadizad firouzjaei
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    3. Fatemeh darijani
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    4. Jamshid Gholizadeh Navashenaq
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    5. Eskandar Taghizadeh
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    6. Majid Darroudi
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    7. Seyed Mohammad Gheibihayat
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    Corresponding author

    Correspondence to Seyed Mohammad Gheibihayat.

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    Mahmoudi, A., firouzjaei, A.A., darijani, F. et al. Effect of diabetes on efferocytosis process. Mol Biol Rep 49, 10849–10863 (2022). https://doi.org/10.1007/s11033-022-07725-2

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    • DOI: https://doi.org/10.1007/s11033-022-07725-2

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