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Cerium ammonium nitrate (CAN)-catalyzed four-component one-pot synthesis of multi-substituted pyrano[2,3-\(\varvec{c}\)]pyrazoles under ultrasound irradiation

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Abstract

A convenient and efficient synthesis of multi-substituted dihydropyrano[2,3-c]pyrazole derivatives is reported. The four-component reaction of 4-hydrazinobenzoic acid, \(\beta \)-keto esters, aromatic aldehydes, and malononitrile using 10 mol% CAN catalyst in water under ultrasound irradiation produced the target compounds in good-to-excellent yields. This method has advantages over conventional methods in being economic, non-toxic, and environmentally compatible due to its use of efficient and eco-friendly CAN catalyst and water solvent.

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Acknowledgments

This work was supported by the Natural Science Foundation of China (No. 21162028) and the Natural Science Foundation of the Xinjiang Science Technology Agency (No. 2009 211A02).

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Authors and Affiliations

  1. Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Ürümqi, 830046, People’s Republic of China

    Keyume Ablajan, Wang Liju, Yakefujiang Kelimu & Feng Jun

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  1. Keyume Ablajan
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  2. Wang Liju
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  3. Yakefujiang Kelimu
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  4. Feng Jun
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Correspondence to Keyume Ablajan.

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Ablajan, K., Liju, W., Kelimu, Y. et al. Cerium ammonium nitrate (CAN)-catalyzed four-component one-pot synthesis of multi-substituted pyrano[2,3-\(\varvec{c}\)]pyrazoles under ultrasound irradiation. Mol Divers 17, 693–700 (2013). https://doi.org/10.1007/s11030-013-9465-7

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