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PTBP1 as a potential regulator of disease

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Abstract

Polypyrimidine tract-binding protein 1 (PTBP1) is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a key role in alternative splicing of precursor mRNA and RNA metabolism. PTBP1 is universally expressed in various tissues and binds to multiple downstream transcripts to interfere with physiological and pathological processes such as the tumor growth, body metabolism, cardiovascular homeostasis, and central nervous system damage, showing great prospects in many fields. The function of PTBP1 involves the regulation and interaction of various upstream molecules, including circular RNAs (circRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). These regulatory systems are inseparable from the development and treatment of diseases. Here, we review the latest knowledge regarding the structure and molecular functions of PTBP1 and summarize its functions and mechanisms of PTBP1 in various diseases, including controversial studies. Furthermore, we recommend future studies on PTBP1 and discuss the prospects of targeting PTBP1 in new clinical therapeutic approaches.

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Acknowledgements

We would like to thank Editage (www.editage.cn) for English language editing.

Funding

This work was supported by the National Natural Science Foundation of China (82271425); the Industrial Technology Research and Development Project of Development and Reform Commission of Jilin Province (2022C044-5); and the Technology Development Plan Project of Jilin Province (20220101278JC).

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  1. The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, 130021, Jilin, People’s Republic of China

    Qi Yu, Tongtong Wu, Wenhong Xu, Junyuan Wei, Anqi Zhao, Miaomiao Wang, Meiying Li & Guangfan Chi

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  1. Qi Yu
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  2. Tongtong Wu
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Contributions

QY and TW drafted and edited the manuscript, QY designed and prepared the figures and the tables, WX and JW commented on previous versions of the manuscript, AZ and MW were in charge of proofreading manuscripts, ML and GC critically revised the manuscript, and supervised the overall work.

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Correspondence to Meiying Li or Guangfan Chi.

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Yu, Q., Wu, T., Xu, W. et al. PTBP1 as a potential regulator of disease. Mol Cell Biochem (2023). https://doi.org/10.1007/s11010-023-04905-x

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