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Evaluation of the Wnt signaling pathway as a prognostic marker in patients with urosepsis

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Abstract

The Wnt signaling pathway has critical roles in dysregulated inflammation during sepsis; however, its impacts on clinical outcomes remain uncertain. This prospective observational study investigated the association between the Wnt pathway and clinical outcomes in patients with urosepsis. The study included 38 patients with urosepsis and 20 healthy individuals. Wnt3a and Wnt5a levels were measured at admission. The primary outcome was the occurrence of major adverse kidney events (MAKE), defined as new renal replacement therapy, stage 3 acute kidney injury, or death. Both Wnt3a and Wnt5a levels were higher in the patient group than in the control (P = 0.001 and P < 0.001, respectively). The primary outcome occurred in 13 (34.2%) subjects. The levels of Wnt5a were higher in subjects with MAKE than in those without MAKE (P = 0.015); however, Wnt3a levels showed no significant difference. Moreover, Wnt5a levels could be a marker to predict the possibility of MAKE (area under the curve 0.74 [0.57–0.92]; P = 0.016). Serum creatinine levels on day 0, day 5, and on discharge day were evaluated. The levels of creatinine on discharge day were higher in patients with high Wnt5a levels, compared to those with low Wnt5a levels (P = 0.030); however, no difference in Wnt5a levels was observed on day 0 and 5. Wnt3a and Wnt5a levels increased in patients with urosepsis. Moreover, evaluation of Wnt5a levels might help to predict the occurrence of MAKE and renal recovery in these patients.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

This work was supported by the Korean Society of Dialysis Therapy. The authors would like to extend their gratitude to the Korean Society of Dialysis Therapy.

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Authors and Affiliations

  1. Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea

    Jungho Shin

  2. Department of Microbiology, Chung-Ang University College of Medicine, Seoul, Korea

    Yoosik Yoon

  3. Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, 5 Hwasu-ro 14, Deogyang-gu, Goyang, 10475, Korea

    Dong-Jin Oh

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Contributions

DJO is a corresponding author. DJO involved in study conception and design; DJO did data collection; JS and YY performed data analysis; JS and DJO contributed to writing original draft preparation; and YY and DJO did supervision.

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Correspondence to Dong-Jin Oh.

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This study was approved by the Institutional Review Board (IRB) of Myongji Hospital (IRB number: MJH 2017-09-018-029).

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Shin, J., Yoon, Y. & Oh, DJ. Evaluation of the Wnt signaling pathway as a prognostic marker in patients with urosepsis. Mol Cell Biochem 473, 15–23 (2020). https://doi.org/10.1007/s11010-020-03804-9

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  • DOI: https://doi.org/10.1007/s11010-020-03804-9

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