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Determination of major radionuclidic impurities in K99TcO4 pharmaceutical raw material

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Abstract

A rapid analytical method for sequential separation and determination of the most significant α- and β-emitting radionuclidic impurities in 99Tc radiopharmaceutical raw material is presented. Successive HTiO co-precipitation steps were first conducted for effective removal of 99Tc to avoid its spectral interference on the determination of β-emitting nuclides by liquid scintillation counting. A sequential chromatographic method was applied for simultaneous separation and purification of actinide and lanthanide isotopes. A series of K99TcO4 solution spiked with known quantities of 238Pu, 239Pu, 241Pu, 237Np, 241Am, 244Cm and 147Pm were analyzed for method evaluation, demonstrating that the method would meet the analytical requirements for radionuclidic impurity evaluation of K99TcO4 raw material.

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Acknowledgements

This work was supported by the Ministry of Science and Technology of China (2015FY110800) and the National Natural Science Foundation of China (11605206 and 12005197).

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Authors and Affiliations

  1. China Institute for Radiation Protection, Taiyuan, 030006, China

    Maoyi Luo, Shan Xing, Yang Wu, Daqian Liu & Xiongxin Dai

  2. Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215006, China

    Maoyi Luo & Xiongxin Dai

  3. Atomic High Technology Co., Ltd., Beijing, 102413, China

    Ji Hu

Authors
  1. Maoyi Luo
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  2. Ji Hu
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  3. Shan Xing
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  4. Yang Wu
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Correspondence to Xiongxin Dai.

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Luo, M., Hu, J., Xing, S. et al. Determination of major radionuclidic impurities in K99TcO4 pharmaceutical raw material. J Radioanal Nucl Chem 330, 37–45 (2021). https://doi.org/10.1007/s10967-021-07902-w

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  • DOI: https://doi.org/10.1007/s10967-021-07902-w

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