Systematic literature review paper: the regional innovation system-university-science park nexus

Recent work on Region Innovation Systems (RIS) has emphasised the importance of universities. Until recently, however, related insights into the dynamics of this relationship in respect of the specific role of the science park have been limited. This paper presents a systematic review identifying the key roles of each actor in relation to innovation. We link the dynamic roles performed by the university between science parks and the RIS. Our results enable us to identify how the key activities performed by the university change during its interrelations within the RIS and with the science park. Our analysis of the literature distinguishes between three sets of relationships through which the university plays differing roles: RIS-university, RIS-university-science park, and university-science park. Respectively, the University’s relationships between these different RIS actors focuses on: resource sharing, brokerage, and commercialisation-exploitation. Secondly, we find that within each of these relationship types the university can perform three types of roles: on knowledge co-creation, acting as conduit, and inter-organisational relationship building. Distinguishing between these differing relationships and roles enables us to identify a total of nine dynamic roles performed by the University, which include: provision of information, channels of communication, infrastructure, regional networking, building research collaboration, acting as knowledge intermediaries, economic development, technological change and commercialisation processes, and start up creation and commercialisation. The review identifies several gaps in the literature in need of further research, and suggests that university relationships with RIS, interlinked with those between the university and science park itself, are important factors affecting science park innovation performance.


Introduction
Universities' traditional roles, of teaching and research, are increasingly being supplemented by government policies aimed at increasing the "entrepreneurial" activities as a way to help develop the economy, for example through student start-ups (Wright et al. 2017). Whilst it is not new, the "entrepreneurial university" concept adopted by a growing number of universities has supplemented the two traditional roles of universities with the need to help develop regional economies (e.g. Etzkowitz and Leydesdorff 1999;Gunasekara 2006;Malairaja and Zawdie 2008). Consequently universities, through the concept of the triple helix (Etzkowitz and Leydesdorff 2000), are increasingly participating in entrepreneurial activities (see for example, . Policy makers and governments are increasingly looking to Universities to contribute to the regional innovation system (RIS) and/or entrepreneurial ecosystem (Feldman et al. 2019), as part of building the knowledge based economy and fostering regional competitiveness. This role of the university in regional economic and social development has heavily influenced policy over the past 20 years (Acs et al. 2009;Leydesdorff 1996, 1999), further altering the role of universities. Science parks (SPs) act as an important tool in regional development policy, and can be considered as property-based policy interventions to support commercialization of research results from universities (Appold 2004;Vedovello 2002). This paper, therefore attempts to link the literatures concerning RIS and SPs, via the role of the entrepreneurial university, to provide understanding of how SPs are conceptualised and how these literatures link findings on universities and SP's to the RIS.
In both RIS and science park literatures universities play a critical role. They form a key and integral component in the RIS and have important linkages with science parks. There has, however, been no systematic integrated investigation into how the roles performed by the university change depending on the nature of the interaction and the actor involved. Moreover, only a limited number of studies focused on science parks incorporate the RIS, with even fewer focused on the university as a key stakeholder within this. This gap therefore requires us first to integrate findings from these two literatures and identify what they have found and focused on thus far. Then we focus specifically on two basic research questions: First, what are the key roles and foci of the university in its relationships with the science park, within the RIS? Second, how do these key roles and foci change through interrelations between university, science park and the surrounding RIS environment?
In both RIS and science park literatures universities play a critical role. They form a key and integral component in the RIS and have important linkages with science parks. There has, however, been no systematic integrated investigation into how the roles performed by the university change depending on the nature of the interaction and the actor involved. Moreover, only a limited number of studies focused on science parks incorporate the RIS, with even fewer focused on the university as a key stakeholder within this. This gap therefore requires us first to integrate findings from these two literatures and identify what they have found and focused on thus far. Then we focus specifically on two basic research questions: First, what are the key roles and foci of the university in its relationships with the science park, within the RIS? Second, how do these key roles and foci change through interrelations between university, science park and the surrounding RIS environment?
In order to answer these questions this paper follows a systematic literature review approach constructed from literatures on "science parks" and "RIS incorporating science parks" with the intention of linking both literatures together. This approach provides a framework of protocols through which the relevant literature is identified, findings reported, and contribution of the study and research gaps identified (Macpherson and Holt 2007;Tranfield et al. 2003).
The findings of our review provide three key contributions to the literature. First, we clarify the three types of relationships between the university and the key stakeholders: knowledge co-creation, acting as conduit, and inter-organisational relationship building. Second we identify three specific roles performed by the University: resource sharing, brokerage, and commercialisation-exploitation. Third, we identify how the University's roles change during its interactions between RIS-university, RIS-university-science park, and university-science park, identifying nine specific sets of activities the University performs, which depend on the focus-role interdependency.
The next section begins with a brief discussion of the ex ante literature, focusing on the definition of RIS actors and dynamics of the local innovation ecosystems. This is followed by a description of the research methodology. A review protocol is developed, publications are selected and grouped and classified, prior to reporting the results of the subsequent analysis. Finally, we identify gaps for future research.

Ex ante literature review
The RIS approach incorporates the development of the "entrepreneurial university" with knowledge spillovers. The interrelationships between the triple helix actors to encourage learning processes in the region also form key aspects of the RIS, which has resulted in universities expanding and updating their research agendas to better meet industrial needs and enhance links with industry (Vedovello 2002). For example, academic researchers are able to commercialise their research results and exchange knowledge with firms located on the science park. In so doing, science parks offer a crucial resource network for new technology-based firms (NTBFs) (Westhead 1997). This then both fosters and supplements the role of the science park as an interactive mechanism for systemic university-industry cooperation (Asheim and Coenen 2006;Vedovello 2002).
The RIS represents an interconnected context and resource, defined in terms of both actors and dynamics within the local innovation ecosystem. In terms of actors, the importance of innovative local agencies (Asheim and Isaksen 2002), regional and local government governance actors and institutions (including universities), also science parks (Zhang 2015), other key infrastructure providers (Gerstlberger 2004;Takeda et al. 2008), and the international connections (Lew et al. 2018) have been identified.
In terms of dynamics, Zhang (2015) then highlights national and local policies in human resources and land development, whilst Asheim and Coenen (2005) identify that "regional culture" is relevant to knowledge production and uptake (Rip 2002). Cooke and Morgan 1998). To design a sustainable RIS researchers have indicated that resourcing the development of relevant infrastructure is one of the criteria necessary for success, the infrastructure itself forms an essential determinant for firm location choice (Gerstlberger 2004;Takeda et al. 2008). Cooke and Morgan (1998) also identify that robust RIS also have levels of institutional thickness, with different actors playing different roles at different levels.
In the case of universities, Fuller et al. (2019), Pickernell et al. (2019) and Ishizaka et al. (2020) identify, previous dichotomous definitions of universities into being research or teaching focused, can now be seen to be too simplistic. Universities instead exist along a spectrum between these two extremes, offering different combinations of supporting relevant research and training activities within RIS. Whilst as will be seen, there is no consensus on what constitutes a science park, broadly they can be seen as characterised by links with academic institutions (usually research focused), supporting start-up/incubation of technology-based firms, fostering transfer of technology and business knowledge, property-based, and sustainable (Durão et al. 2005). Science parks also help (usually more research-focused) universities build and improve their reputation (Helmers 2019;Link and Scott 2017) within the RIS.

Methodology
In order to be systematic, transparent and replicable, our review involved two processes. This follows the approach of Macpherson and Holt (2007), who themselves followed refined protocols outlined by Tranfield et al. (2003) and Pittaway et al. (2004). First, we define the review protocols and map the literature by: (1) accessing, (2) retrieving and (3) judging the quality and relevance of the literature in relation to the research topic, according to explicit inclusion and exclusion criteria. As part of this we classify the quality of papers, following Turner et al. (2013) approach of selecting papers categorised by journal rating (based on the Chartered Association of Business School's (CABS) Academic Journal Guide 2018). This produced the following review protocols and processes, summarized in the table below, and then discussed in more detail (Table 1).

Review protocols
The papers included in this study were identified from the electronic databases Business Source Complete, Web of Science, and Scopus restricted to English language academic papers in the categories of "technological innovations, research parks, technology, and business incubators" (Business Source Complete), "business and management" (Web of Science), and "business, management and accounting" (Scopus).
Three inclusion criteria were used within our systematic review process: (1) Papers that reviewed secondary data analysis if the purpose of the review was to identify future research or policy agendas because they offer the working assumptions to be used in this study, or primary quantitative or qualitative empirical studies. (2) Articles had to be published after 1990. This time period is selected due to the concept of RIS most consistently appearing and being developed during the 1990s, the literature on science parks also most strongly observed during this period, and also the need to focus on policy developments in the context of these more recent developments. (3) Following Savino et al. (2017) only academic journal articles were included. It must be recognised that the approach taken has deliberately excluded non-journal outputs from the review, which will potentially exclude relevant and important contributions from books, such as Link and Scott (2015) and Wright et al. (2019). This follows the approach of Keupp et al. (2012), in which book reviews, book chapters, conference proceedings and working papers were excluded. An initial list of keywords based on ex ante analysis of the literature yielded 3 keywords. We then conducted Boolean searches on combinations of the keywords (and their variants, to acknowledge the different terminologies used around the world.) identified. For example, these searches included 'Science park', 'Research park', 'Technopole', 'High-Tech park', 'Technology park', ''Regional Innovation System' and Science park'. The total number of potentially relevant articles retrieved using search strings alone was 1735.
Once duplicate articles were excluded, 1089 papers remained. To then identify the papers directly related to the topic and classify these papers, the papers were evaluated systematically, beginning with the journal quality, then examining the content of abstract and introduction, literature review, and conclusion in order to exclude irrelevant articles (using the exclusion criteria in Table 2).

Mapping the field
Utilising the described process, 151 papers were identified as directly related to the topic. Table 3 categorises these articles by journal in Table 3, using ratings from the CABS Guide 2018. 90 papers were published in journals rated as CABS4 or CABS3 (59.60%), while 61 papers were rated as CABS2 (40.40%), shown in Table 3 according to the numbers of selected papers published in each journal. Technovation and the The paper did not describe the concept of RIS and did not refer to science parks or other terms for science park. The studies were only tangentially related to RIS, referring to science parks, but primarily focused on The relationships between regional innovation initiatives (RII), knowledgeintensive business services (KIBSs) and value chain information sources on absorptive capacity (AC) and innovation performance The Focusing on the overlaps in broad topic area covered by the papers, 119 articles originate from the science park literature, seventy-one of these also indicating the roles and interactions of the university and science park. The remaining thirty-two articles had a RIS literature emphasis, whilst incorporating science parks within their analysis (i.e. RIS with a science park emphasis). These articles can be divided into: (1) eighteen papers which referred to the science park and asserted the roles and interactions of university and RIS, (2) eight papers referring to the science park but focused mainly on RIS and without the university, (3) two paper conducting research on the science park and relevant to RIS concepts without mentioning the university, and (4) four papers conducting research focused on the science park and including both RIS concepts and the role of the university. With respect to the study locations, the literature on science park without a RIS-science park emphasis is shown in Table 4. The results identify a concentration on single country studies, particularly in the Taiwan, UK, Sweden, China and Spain. Conversely, the literature on RIS-science park emphasis (Table 5) is relatively more focused on multi-country studies, with a strong focus on more developed economies.
Finally, in terms of the analytical focus of the papers, (shown in Table 6), secondary review papers and mixed method papers each have 10.60% of the total. Overall, there is a

Reporting the findings
Following Savino et al. (2017) the analysis of the literature is divided into two sections, informed by the Research Questions. We follow processes similar to Macpherson and Holt (2007), by first providing a broad descriptive review of the literature (Tranfield et al. 2003), according to the broad RIS-University-Science Park framework on which the data had been initially collected, to identify context. Following this, continuous inductive and iterative coding and sensemaking processes (Williams 2002), compared the literature to generate summarizing themes through which the different roles of the university in RIS actors-university-science park nexus could be identified.

Defining the science park
The concept of science parks can be traced back to the 1950s when the Stanford Science Park was founded by Stanford University in California. Science parks boomed throughout Europe during the 1980s and 1990s (Bakouros et al. 2002;Storey and Tether 1998), and in Asian countries in the mid-1980s . Simultaneously, a number of other types of property-based developments with similar roles to science parks exist, particularly technology parks, technopoles, innovation parks, and research parks (Sofouli and Vonortas 2007). According to Link and Scott (2003a, b) each can distinguished as follows: (1) research parks are characterized by tenants that are mostly engaged in basic and applied research, (2) science parks (including technology parks) are characterized by tenants that are more heavily engaged in applied research and development, (3) technology or innovation parks in particular often house new start-up companies and incubation facilities. Commercial or industrial parks can also be distinguished from science parks on the basis of their tenants who apply value-adding activities to existing R&D-based products or production-orientated activities, as opposed to conducting R&D activities (Cheng et al. 2014;Huang et al. 2012;Link and Scott 2003b). Also, whilst Technopoles and initiatives like the multimedia super corridor (MSC) often share similar goals to science parks (Boucke et al. 1994;Chordà 1996;Ramasamy et al. 2004), they differ in often being created by government and having a much larger physical scale (Chordà 1996;Ramasamy et al. 2004). Given the above discussion, however, there is no uniformly accepted definition for the science park (Cheng et al. 2014;Fukugawa 2006;Hansson et al. 2005;Lindelöf and Löfsten 2006;A. Link and Link 2003;A. N. Link and Scott 2003b;Löfsten and Lindelöf 2001, 2003. Phan et al. (2005) also demonstrates that no general theory for the science park exists due to the origins and consequences of the parks being varied depending on their economic geography, political and social context, as well as, economic systems. In brief, however, a science park is typically characterised by: (1) having links with academic institutions (2) supporting the start-up and incubation of technology-based firms (3) fostering the transfer of technology and business knowledge, (4) property-based initiatives, and (5) their sustainable nature (Durão et al. 2005). Universities then obtain income from technology transfer as well as receiving opportunities for their personnel and students from interacting at applied levels with technology-based organisations, science parks also helping universities build and improve reputation (Helmers 2019;Link and Scott 2017).
Whilst universities are often instrumental in founding science parks, this activity is more concentrated in some countries and universities than others. In the UK, the Cambridge, Heriot-Watt, and Surrey Science Parks were each set up by universities (Westhead and Batstone 1998) whilst in Sweden, universities have worked alongside local authorities and development agencies to encourage the formation of heterogeneous groups of parks . By contrast, the Kista science park evolved from a cluster centred on Ericsson into the Kista Science City and did not need a university as a precursor to its establishment (Cabral 1998). Whilst in Japan the "centre facility" approach involves a public-private organization takes on the role of the university to offer facilities and services to entrepreneurs (Bass 1998). Ng et al. (2019) also indicate that science park ownership has diversified to include combinations of public and/or private sector actors, which can also affect the focus of their activities. The privately owned Kilometro Rosso Science Park in Italy, for example, specifically aims to promote networking amongst relevant partnerships as well as enhancing interactions between on-park and off-park firms (Corsaro and Cantù 2015), Layson et al. (2008) also identified that privately owned science parks often seek to limit the number of firms in the park, even where there is nominally free entry. Conversely, university owned science parks more specifically focus on knowledge spillovers (Alshumaimri et al. (2017) offering the entrepreneur access to the intellectual resources of academic staff and advice to establish a new venture ), but also provide less access to commercially oriented expertise and contacts than non university-affiliated parks. According to Albahari et al. (2017), higher university involvement also positively affects tenant firm patent applications but negatively affects their innovation-related sales. Therefore, a universityowned science park is likely to be a strategic choice for a firm with both benefits and costs.

The performance of science parks
In terms of performance, science parks clearly aim to generate the growth of new technology-based firms (NTBFs), on-park firms are expected to "perform better" or benefit from greater "added value" than equivalent off-park firms (Löfsten and Lindelöf 2002;Radosevic and Myrzakhmet 2009). However, Markman et al. (2008) indicate that there is a problem in terms of defining science park effectiveness, particularly with respect to measures of on-park firm survival, wealth creation, and employment growth. To explore effectiveness, researchers have therefore compared on-park with off-park firms in terms of: innovative performance (Chan et al. 2010;Lindelöf and Löfsten 2003;Löfsten and Lindelöf 2001;Radosevic and Myrzakhmet 2009), facilities management (FM) (Dettwiler et al. 2006), R&D productivity of firms (Siegel et al. 2003a;C. H. Yang et al. 2009), the performance of firms , product development (Lindelöf and Löfsten 2004), perceived benefits of being in a science park (Westhead and Batstone 1998), survival and growth rates (Ferguson and Olofsson 2004), improvement in economic performance and innovative capacity (Liberati et al. 2016), contribution to NTBFs (Fukugawa 2006), links with local HEIs (Storey and Tether 1998), R&D "inputs" and "outputs" (Westhead 1997), innovative output (Squicciarini 2008), university-industry collaboration (Malairaja and Zawdie 2008), performance of NTBFs (Siegel et al. 2003b Given this plethora of potential performance measures there are many identified determinants of science park performance. For example, a strong management team is recognized as a characteristic of successful science parks (Cabral 1998). Albahari et al. (2013), introduced a framework to analyse science park systems (SPSs). Applying it to the Italian and Spanish contexts, they found that science parks played a more essential role in Spain than in Italy because of the more coherent and specific policies supporting the parks, sounder business models, and government intervention in the medium-long term. Guadix et al. (2016) define successful science parks as those that have overcome initial hurdles to have high land occupation rates, housing firms that generate high revenue and numbers of employees. The availability of R&D centres and academic institutions encouraging the development of specialised knowledge and knowledge transfer amongst the various stakeholder organisations are crucial in this, as demonstrated in the case of Sophia Antipolis (Barbera and Fassero 2013). Eto (2005) also indicated, however, that technoparks in Japan are often located in rural areas, often distant from train stations, highlighting obstacles to promoting high/new technology park performance. Hu (2007) found, therefore, that most of China's technology parks are located in large core urban areas where technological, educational and industrial resources are also concentrated.
Science park performance can therefore be seen to be at least partly the result of public-private partnerships, with multiple organisations involved in influencing their mission and operational procedures ). Government support is therefore an important factor in determining the likelihood of success. For example, studies in Japan (Westhead 1997;Park 2004) have demonstrated the importance of central and local governments in supporting the development of SP through active involvement, national and research institutes, and strategies to promote industrial R&D. Likewise, the success of BIORIO in Brazil was attributed to dynamic government funding, alongside researchorientated institutions and a research orientated private sector (Cabral 1998). Vaidyanathan (2008) also identified the key role of the Indian government's business model, which fostered links between public, private, and foreign sectors. Etzkowitz and Zhou's (2018) conclusion that the success of science parks is at least partly reliant on their being part of broader regional University-Industry-Government interactions also reinforces the importance of the wider RIS to science park success.
Beginning with the broad RIS-University-Science park framework in which innovation takes place, therefore, two basic categories of analysis were identified: (1) the main roles and (2) focus of each of the key stakeholders and the relationships between them.

The key role of the RIS in resourcing
According to Buesa et al. (2006)the RIS acts as a set of public and private organisations forming a network and interacting to create and spread knowledge and innovation within a specific territory. Articles that fall within our study parameters emphasise the importance of this RIS context. Specifically, this context acts as a trigger to defining what can or cannot be achieved. Hence, alongside government support, the university's role and the science park's functions and performance crucially depend on the RIS. The implication being that otherwise these functions will not operate optimally.
The concept of the Regional innovation system (RIS) highlights the importance of a range of institutions, national and local policies in human resource development, local government, and designation of land development, which can include high-tech parks, science and industrial parks (Zhang 2015). This supports interactive learning and helps explain differences in regional innovation performance and economic growth (Asheim and Coenen 2006;Cooke 2002aCooke , 2003. Asheim and Coenen (2005) also identify the importance of fostering "regional culture" in the development of a RIS, dynamics eventuating not only from general economic processes but also sociological circumstances relevant to knowledge production and the uptake of new knowledge (Rip 2002). A dense inter-organisational network within a region is therefore key to encouraging knowledge diffusion, regional learning, and effective resource transfer in RIS (Takedad et al. 2008), specifically when surrounded by supporting innovative agencies (Asheim and Isaksen 2002). Whilst Lew et al. (2018) also highlighted the importance of international connections of regional innovation actors, strong government innovation policy initiatives, and regional R&D collaboration.
The RIS therefore represents both a context and a resource, where the region is a network of connected actors, built up by regional resources within the network, allowing knowledge to be transferred across agents. (Cantner et al. 2010), with the impact of regional policies in the creation and development of science parks a specific area of analysis suggested by Mora-Valentín et al. (2018). This is supported by strong regional governance, defined as the capacity to develop the policies and organisations required (Cooke and Morgan 1998). To design a sustainable RIS researchers have indicated that resourcing the development of relevant infrastructure is one of the criteria necessary for success, the infrastructure itself an essential determinant for firm location choice (Gerstlberger 2004;Takeda et al. 2008).

The key role of the university in brokering knowledge between the RIS and science park
Universities have been identified as a major component of the RIS, and they play a crucial role in brokering knowledge (Chung 2002;Gunasekara 2006;Kramer et al. 2011;Lew et al. 2018), which differs to other parts of the RIS. Whilst universities are often crucial actors in their regions in terms of employment and economic activity (Löfsten and Lindelöf 2005), they play an important role as both direct and indirect sources of knowledge production, which they are able to feed or diffuse into the RIS (Cooke 2002a, b;Lew et al. 2018).
Universities are therefore specifically important in both the knowledge generation and diffusion subsystem of RIS, as well as subsequent knowledge application activities and connections with firms that aim to exploit the knowledge for commercial returns (Cooke 2002a). It is in this exploitation role, however that science parks can be seen to have a specific role in conjunction with universities.

The key role of the science park in exploiting innovation
The science park can therefore be seen to play the role of a catalytic incubator environment for transformation of pure research into production. Authors such as Feldman (2007) highlight the role of science parks in innovation exploitation (Huang et al. (2012), potentially generating smaller (Staudt et al. 1994) or larger (Storey and Tether 1998) benefits in terms of employment growth as well as via better sales and sales growth performance (Gwebu et al. 2019). More specifically for SME's they have been identified as regional growth engines (Cheng et al. 2014) creating wealth and high value job opportunities through technology based-research and development (Chang et al. 2010).
Science parks also offer a social environment where proximity between firms supports key information transfer for the development of innovation (Fernández-Alles et al. 2014). Within science parks, firm proximity can enhance the interaction between personnel and extend the networking to support the development of innovation, as seen in the case of Hsinchu Science-based Industrial Park (HSIP) and Tainan Science-based Industrial Park (TSIP) (T.-S. Hu 2008). In addition, science parks can be used by the government to promote innovation in specialised sectors in specific localities, either in single sectors (e.g. biotechnologies in agro-food industry in Lombardy (Bosco 2007) or multiple related hightech sectors in Hsinchu Science park (Chen et al. 2006). Connection between science parks could also form allowing greater exchange of knowledge in specialised sectors (Yang et al. 2009).

The Interrelationships between RIS, University and Science Park
Science parks also, however, utilize the physical and network infrastructure created through the RIS, alongside their relationships with the universities that support them, to facilitate flows of knowledge with the potential of commercialisation into new firms created on the science park itself to produce innovation exploitation outcomes. Thus, science parks can also be defined as intermediate structures which established around universities e.g. IDEON (Angelakis and Galanakis 2017) or brokerage intuitions that attract firms and other organisations for cooperation (Almeida et al. 2011) or innovation support infrastructure (Diaz-Puente et al. 2009;Doloreux and Dionne 2008) or facilitators of inter-organisational relationships (Pilar Latorre et al. 2017).
However, whilst Lenger (2008) found that for technoparks (or science parks) and university-industry joint research centres, universities are key actors, making significant contribution to RIS, the roles and interactions of science parks as well as a numbers of parks differ according to the specific RIS. For instance, Huang and Fernández-Maldonado (2016) found that in the Eindhoven city-region, each science park focused on a single field of R&D facilitating the clustering of relevant industries and acting as a hub for the regional economy. Conversely, where there is only one science park in a region, this must more broadly support regional technological strengths. For example, where this situation exists in the Beauce region of Canada, this highlights the 'institutional thinness' characteristic of peripheral regions (Doloreux 2004). Gebauer et al. (2005) also demonstrate that the multiple small innovation centres in more rural/economically peripheral areas of Western Germany often lack critical mass because of the localities in which they are located. Lecluyse et al. (2019) identified a need for more research into the relationship between economic geography and science park when analysing the contribution of the science park to the economy, Gkypali et al. (2016) suggesting that the science park needs to orientate itself within the RIS in which it finds itself.
The preceding discussion also highlights, however, that whilst the RIS, universities and science parks have different roles in the innovation process, there are also clear, strongly overlapping relationships through which these roles are displayed. We utilise the linear approach (e.g. Massey and Wield 2006;Quintas et al. 1992;Westhead 1997), as an initial simplifying framework to structure the sections that follow (see Fig. 1), whilst also identifying the overlapping two-way relationships between activities.
Respectively, these sections discuss: (1) The university-RIS relationship which demonstrates an emphasis of activities on the dissemination of basic research, (2) the RIS-University-Science Park relationship emphasising product development activities, and (3) the Science Park-University relationship, which in which the emphasis is on applied research. Rip (2002) emphasized how universities have evolved to more closely support both regional innovation systems and strategic science, which can also be seen as constituting basic research. Rip's (2002) case study analysis of the University of Twente in the University Science Park RIS RIS-University-Science Park U n iv e rs it y -S c ie n c e P a rk R IS -U n iv e rs it y Fig. 1 The sets of RIS-university-science park relationships Netherlands found; "The University of Twente has a strong regional orientation, but that its spin-offs strengthen the economy, not necessarily the regional innovation system. It is also prominent (in selected areas) at the international research frontier. Promising options are a key feature of strategic science, but their 'promise' most often is not defined in regional terms, but in relation to a global scientific and technological frontier." (p. 129).

The university-RIS relationship and its focus on basic research for dissemination
The interaction between the university and other RIS actors can be seen as 'knowledge co-creation' (Gunasekara 2006). In this scenario, universities have the main role of coordinating the production of knowledge and disseminating it to other actors in the RIS, but universities also cooperating with regional firms to undertake collaborative projects to conduct the basic research and create the new knowledge. The relationships between the university, the wider RIS and science park actors can then be viewed as 'conduits' for knowledge flows within entrepreneurial RIS (Yoon et al. 2015). The science park in this type of relationship fosters linkages between the university and the other RIS actors, enhancing product development and commercialising products. The last relationship occurs specifically between the university and science park actors. Defined as 'inter-organisational relations' (Gunasekara 2006), many subtypes of links may exist. More linkages are created the more organisations are involved, including the government, researchers, firms, policymakers, business ventures, and so on.
Whilst the focus for basic research for dissemination is through relationships between the university and key stakeholders, and theoretically includes the processes of knowledge co-creation, acting as conduit, and interorganizational relationship building, several studies also suggest weaknesses in Universities' abilities to enhance the RIS through these mechanisms. Gunasekara's (2006) undertook an analysis of three Australian universities, utilising a conceptual framework based on the triple helix model, literature on university engagement, and innovation systems. This research found the universities to be weak in their willingness and capability to act like industry, generating poor commercial benefits. In Daedeok Innopolis, universities were also found to have strong links with public research institutions, but weaker links were demonstrated between firms and universities (Yoon et al. 2015). Hence universities are often perceived to be relatively weak in this aspect as a result of a greater focus on education over those activities of most relevance within many RIS, specifically R&D activities which are closer to market (as opposed to basic research). It was these weaknesses that led Chung (2002) to suggest the need for policies supportive to innovation, such as the recruitment of experienced professors and collaboration between academics and researchers in research centres. It is also in this context that the science parks can be seen as helping to facilitate a better flow of university generated knowledge into innovation.

The RIS-university-science park relationship and its focus on product development
Many governments globally have used science parks to stimulate the regional economy by fostering the growth of NTBFs and science-based industry. For example, the government of Taiwan established science parks, officially defined as offshore economic zones, with complementary business services and financial incentives provided to high-technology manufacturers (Tsai et al. 2007). To date, however, there have been only a limited number (6) of studies focusing on science parks whilst also incorporating the RIS, four of these six papers also discussing the role of the university within this context with each taking a different focus..
For Zhang (2015) the concept of the RIS itself identified the importance of institutions, human resource and land development, which included science parks. Zhu and Tann (2005), viewed the science park as an RIS in its own right, as well as playing roles and interacting with the university to help develop the wider RIS. Hommen et al. (2006) found a specifically important role in the Swedish context for university education, training and intellectual property management to the development of the RIS. For Jonsson (2002), the role of the university was specifically important in developing and supporting communication in RIS networks, whilst for Yoon et al. (2015) the building of formal and informal relationships in the RIS by universities was of particular relevance. Given these different foci Gkypali et al. (2016) identify the need to place the science park in its specific RIS context. The limited number of papers identified, however, both generally, and within the university category, as well as the disparate focus of these papers, again highlights the lack of studies in this specific area.
Taking a broader perspective, for universities to become more effective in their RIS the knowledge they supply must fit with the needs of their region's firms and raise future interest in their services, through product development (e.g. Tödtling and Kaufmann 2002). Consequently many universities have set up science parks and incubation centres to help firms overcome obstacles in the innovation process and strengthen university-industry interactions (Asheim and Coenen 2006;Gunasekara 2006;Malairaja and Zawdie 2008;Vedovello 2002). These are supported by Technology Transfer Offices (TTOs), which require close proximity and systemic links between university and industry.
Science parks are also viewed as policy instruments for encouraging regional development, innovation, and the setting up of new firms through networks between higher educational institutions (HEIs) and industry (Hansson et al. 2005;T.-S. Hu et al. 2005). In particular policy makers see science parks as "meta-organisations", important in the task of getting small and medium-sized enterprises to participate more closely in knowledge creation with universities and research institutions (Giaretta 2013). This underlines the importance of the science park in terms of promoting links with the university, with the aim of making contributions to the regional economy. Indeed, Zhu and Tann (2005) analysed Zhongguancun science park (ZSP) investigated the linkages and the knowledge flows between several actors of ZSP as a RIS in itself, viewing the park effectively as a RIS in itself, acting as: "a social system consisting of different sets of clusters, which interact with different linkages and flows, in a systematic way, to enhance the localized learning and competitive capabilities of a region". In this context, science parks form an important component in the broader government supported RIS. They are seen as a tool of regional development policy through transferring university generated public knowledge to NTBFs, through product development within regional contexts (Fukugawa 2006;Vedovello 2002).

The science park-university relationship and its focus on applied research
There is much research focused on the role that the science park plays in bridging the gap between university and industry (Bakouros et al. 2002;Malairaja and Zawdie 2008;Phillimore 1999;Quintas et al. 1992;Vedovello 2002), though there is much less focus in the literature on the developing economy context when compared to more developed economy examples. As outlined previously, science parks are conceived as a mechanism to help link research results from universities more closely to the market and stimulating technological spillovers (Löfsten and Lindelöf 2005;Siegel et al. 2003a). Consequently, for Universities the main aim of establishing science parks is to exploit their R&D results, research ideas, and secure funding for future research (Hansson et al. 2005).
Proximity between knowledge creators in the university and firms on the science park can also be seen, in a range of geographical contexts, to be important to the attractiveness and growth of science parks (Guy 2002;Ma 1998;Siegel et al. 2003b;Pálmai 2004;Fikirkoca and Saritas 2012;Link and Scott 2003a;Ratinho and Henriques 2010). These links can be divided into forms: formal (e.g. licensing and co-operative alliances), and informal (e.g. personal relations, business partners, family tie and the mobilisation of personnel) (Bakouros et al. 2002;Dettwiler et al. 2006;Lindelöf and Löfsten 2004;Westhead and Batstone 1998). The advantages of close linkages identified within the literature include: access to experts providing improved performance (Dierdonck et al. 1991;Lindelöf and Löfsten 2004;Vedovello 2002), providing the latest knowledge (Markman et al. 2005;McAdam and McAdam 2008), encouraging R&D activities amongst firms (Siegel et al. 2003a), and maintaining and supporting industrial innovation (Hu 2008).
In addition to the receipt of academic knowledge, a number of other factors have been found to influence firm decisions to locate in Science parks. For example, Westhead and Batstone (1998) found that many NTBFs decided to establish or relocate onto science parks because of the "prestige and overall image of the site" and the "prestige of being linked to a HEI/centre of research". A case study of the Tsinghua University Science Park also revealed the significance of reputational benefits from being located on the park to firms (Motohashi 2013). The links between academia and industry within science parks are therefore complex, with Hobbs et al. (2017) arguing for further development of the literature. For Universities, however, proximity to a science park can also fundamentally shift their mission from basic to applied research (Link and Scott 2003b).

The changing roles of the university in the RIS-university-science park nexus
The analysed literature identifies the university as sitting at the centre of a RIS-university-Science park nexus. The University plays an important specific role in its own right as a knowledge broker. It also further contributes through its relationships with the RIS and science park, as these relate to a university's potential basic research, dissemination and applied research activities. The university's focus therefore changes, depending on these relationships. Specifically, in addition to directly brokering knowledge, it plays supporting roles with regards to resourcing and innovation commercialization. Our subsequent analysis therefore focuses on the second question, namely: how do the roles of the university change through its interrelationships within the RIS and with the science park? This is summarised in Fig. 2 below. Details of the empirical evidence from the systematic literature review is summarized in the Tables 7, 8, 9 below, exploring more fully: (1) the parties involved and how the activities associated with specific inter-relationships and (2) the specific importance of the university in terms of resource sharing, brokerage, and exploitation/commercialisation.
Developing upon the preceding discussions, and following an initially linear approach to framing (though recognising and identifying the potentially .6overlapping multi-directional nature of the concepts), the literature in the tables below is initially conceptualized within an innovation "pipeline" reflecting the three different roles performed by the University both singly and through its relationships with the RIS and science park. First, "Resource sharing", includes the offering, facilitating, and supporting of research results, data, and information that the university produced for others actors within the RIS. Secondly, the central University "Brokerage role" encompasses the University acting as a "seedbed", creating conditions to promote innovation as an incubator facilitating the transfer of knowledge, encouraging the spin-offs, and stimulating the production of innovation (Felsenstein 1994). The final role, "exploitation and commercialization", involves activities making use of and benefiting from these resources and brokering activities to assist economic development through innovative products. These are exploited through commercialization processes within the science park to produce commercial returns, which further strengthens the businesses utilizing them and the regional innovation systems in which they sit.

Resource sharing roles
At its interface with the RIS actors the University shares data and knowledge, and thus performs a role in the 'provision of information' (see Table 7). In this function the University itself produces knowledge, it has connections with firms to create and generate new knowledge by conducting research, and shares knowledge or data with firms through university programmes or specific courses (e.g. Hommen et al. 2006;Looy et al. 2003).
Secondly, in its relationship between the science park and RIS, the University then provides channels of communication. Here the University can play a key role in creating networks, as well as helping to ensuring and optimizing communication and cooperation between the key actors (e.g. Jonsson 2002;Watkins-Mathys and Foster 2006). This can play a key role in the transfer of tacit knowledge through a varied network of actors (e.g. Looy et al. 2003;Zou and Zhao 2013). This occurs through conferences, meetings, exhibitions, social networks, as well as firms interactions with students, staff and researchers who have the specialized skills consistent with industrial needs. The final resource sharing role highlights the sharing of infrastructure between the University and Science Park. Here Universities have been identified as providing a range of general facilities, alongside specific tools and specialist laboratory equipment (e.g. Bass 1998;Sofouli and Vonortas 2007).   Boucke et al. (1994) Running regional science centres aimed at coordinating cooperation and information transfer between the HEI and local firms Looy et al. (2003) Setting up technology transfer office (TTO) which one of the information support by the staff of TTO was information exchange through industrial collaborative programme Zou and Zhao (2013) Having intense information exchange through academic, business, and personal network Providing the Channels of Communication (RIS actors + University + Science park) Jonsson (2002) Personal relations between researchers and entrepreneurs providing social contact networks to channel valuable tacit knowledge Löfsten and Lindelöf (2005) University spin-offs (USOs) benefitting from external data transferred through University co-operation from R&D and formal contacts with Universities Looy et al. (2003) Creating Leuven. Inc by K.U. Leuven R&D (TTO) and IMEC (the Inter-university Center for Micro-Electronics) for stimulating the exchange of ideas and the creation of networks Watkins-Mathys and Foster (2006) Having casual social exchanges between researchers, entrepreneurs and officials within and outside the Chinese STIPs, as well as interactions in the community around the parks Zou and Zhao (2013) Enterprises in TusPark operating with Tsinghua University cooperate and communicate with Tsinghua alumni network Provision of Infrastructure (University + Science park) Quintas et al. (1992) Providing land and buildings as well as linkages with tenants located on the park McAdam and McAdam (2008) Provision of office facilities, canteen, car park, telecommunications and shared secretarial services to speed up start up processes Bass (1998) Providing space Westhead and Batstone (1998) Providing access to facilities of HEI/centre of research Kihlgren (2003) Providing the building Bigliardi et al. (2006) Providing access to the available tools Hommen et al. (2006) Providing R&D infrastructure Sofouli and Vonortas (2007) Providing access to the laboratories  Storey and Tether (1998) Providing a formal programme for distribution of knowledge from the university's research directly to firms Hommen et al. (2006) Provision of education and training, supporting the spin-off of academic research into a network of industrial firms and other organizations Yoon et al. (2015) Making a transition toward entrepreneurial university by forming a consortium with other would-be entrepreneurial universities abroad and collaborating with foreign universities and attracting international students to the region. Lew et al. (2018) Developing internship programs Having internationally connected via research, mobility, and exchange programs Ramirez et al. (2013) Via mobility of university generated qualified labour to encourage knowledge diffusion and intangible knowledge transfer Gunasekara (2006) Providing links for the main regional actors in the network, with national and international contacts, to help shape regional networking Research Collaboration (RIS actors + University + Science park) Felsenstein (1994) The University acts as a "seedbed" Jonsson (2002) Having collaborations between on-park firms, individual researchers or teams of researchers at universities, and hospital clinics Koh et al. (2005), Lee and Yang (2000) Facilitating collaboration between firms, universities and institutions, to assist firms into global hi-tech markets Bigliardi et al. (2006) Providing a program of specialist seminars and database the specifies the competences to companies in the innovation and technology transfer programme of science park Watkins-Mathys and Foster (2006) Provision of commercial contracts for R&D (between university incubators and hi-tech STIPs firms) and financial loans to start-up companies to work on technology product development Sofouli and Vonortas (2007) Having links with industry and research centres in joint research projects Malairaja and Zawdie (2008) Having joint collaborative research with science park and off-park firms Knowledge Intermediaries (University + Science park) Díez-Vial and Montoro-Sánchez (2016) Search for and absorb local and non-local knowledge and transmit to the science park Macdonald (2016) Transferring university pool of knowledge to improve innovative capability of firms Jonsson (2002) Having social contact networks, in which university knowledge is channel, to on-park firms Zou and Zhao's (2013) Science park enterprises using knowledge accessed via university alumni network Lai and Shyu (2005) Providing science park with high-quality human resources and on-job training Bigliardi et al. (2006) Consulting and providing access to on-line databases Collaborating with science park to provide quality and certification programme offering integrated services such as consulting, testing, certifying the quality required for commercializing products, etc.  Hommen et al. (2006) Having university Holding located in science park, which commercializes research and ideas serving as 'a bridge between the academic and commercial worlds': providing faculty and students of university who are intent on establishing new businesses with referrals to a number of key services related to the commercialization of research results, in such areas as intellectual property management, access to seed capital, etc. Xie et al. (2018) The role of the University in the development of the Donghu High-Tech Zone as an industrial ecosystem. The University, research institutes and other parties provide a variety of inputs for technology start-ups through the transfer of intellectual property rights or cooperative development Guy (2002) Linking with science park and other universities, aimed to help and keep companies in the forefront of technological advances, by providing a resource for technical research and project-based support

Brokerage roles
The first Brokerage function performed by the University focuses on building regional networking with and between the other actors within the RIS. For example, through labour mobility, contacts and supportive strategy and policy (Table 8). In the University's second brokering role it supports interactions to create and promote innovation between the university, science park, and other actors in RIS. Research collaborations between these actors are considered crucial in this, and across a number of industries R&D collaboration between them is highly valued (Kramer et al. 2011). For firms and the RIS, University's investments in R&D provide benefits that can contribute to their innovation processes (Barra and Zotti 2018), whilst the University benefits from R&D collaboration through additional income and experience of firms' real-life problems (Harper and Georghiou 2005). Finally, within the science park itself the University can then act as a "knowledge intermediary". In this role the university can search for and absorb local and non-local knowledge and then transmit this knowledge to the science park, to improve the innovative capability of firms (e.g. Díez-Vial and Montoro-Sánchez 2016). This role is increasingly promoted by government to encourage technology transfer and regional development due to it supporting the geographical clustering of firms (Tan 2006).

Exploitation and commercialisation roles
In terms of RIS-University relationships, the role of the university also includes directly increasing local economic development (e.g. see Hu et al. 2005). This is achieved through vehicles such as technology companies and innovation campuses (see Table 9). The second exploitation and commercialization role of the University focuses on its simultaneous relationships with the science park and RIS actors (e.g. see Looy et al. 2003). Given that firms' in science parks primary purpose is to launch new products and develop markets , the university's role in commercialization is essential and often supported by specific government policies (Mian et al. (2016). This effort is focused through the development of vehicles for commercialisation (e.g. licensing, patents), as well as more broadly promoting technological change.
In the final exploitation and commercialization role, Universities increasingly participate directly in the commercialization of knowledge via licensing activities and spinoff firms (Looy et al. 2003). The study of Sofouli and Vonortas (2007) supports this notion in their case study of S&T Parks and business incubators of Greece, especially, in the first policy wave (1990's) government providing funding support for establishing parks by universities and other public research institutes in order to exploit R&D results. Spin-off firms are also then seen as crucial in the development of universityindustry relationships and as a tool for valorisation of research results (Salvador 2011). Indeed, Hansson et al. (2005) further claim that universities expect science parks to help them commercialise their research ideas and secure funding for further research (Hansson et al. 2005).

Conclusions, research gaps and implications
The overall aim of this review was to analyse the roles of the university in the RIS actors-university-science park nexus. Whilst it is clear that Universities contribute to both science parks and the RIS, the particular roles they perform for the RIS actors or science park have not been systematically examined. Furthermore, how these basic roles differ between each actor remains ambiguous.
Within this review we have attempted to contribute by focusing on these shortcomings. Specifically, bringing the literature on science parks and RIS together, we have contributed to this field by identifying how the university's key roles change as it moves between: RIS actors-university, RIS actors-university-science park, and university-science park interrelationships. Further, moving beyond basic views of the roles performed by the university (Massey and Wield 2006;Quintas et al. 1992;Westhead 1997), we have specifically distinguished between three different types of activities performed by the university within each of these three types of interactions: knowledge co-creation, acting as conduit, and inter-organisational relationship building. In doing so, we have highlighted how the key basic roles of the university change as these different dimensions interact, thereby making a contribution.
Further research is however, required to provide a more finely grained understanding of the roles performed by the university within each of these relationships, and how their contributions can be optimized in different contexts. Our review also reveals a series of important gaps in the literatures on science parks and RIS. In terms of the science park literature, for example, no general theory of the science park was observed due to the origins of the parks being different depending on a range of factors and the context of the country.
Whilst a broad identification of the roles of the university in the RIS actors-university-science park nexus is possible from the existing literature, an examination of these roles within specific national or regional context is therefore critical in order to identify how this affects the relative significance of specific roles. Our review also supports that of Lecluyse et al. (2019) which identified a need for more research into the relationship between science park and region the science park is located within, in order to more fully explore the roles and contribution the science park can make. In addition, the impact of regional policies in the creation and development of science parks should also be analysed as suggested by (Mora-Valentín et al. 2018).
Our review therefore supports Hobbs et al. (2017) who argued that the science and technology park literature can still be considered to need further development, a situation that can be seen to be particularly the case in the context of peripheral developing economies. More specifically, our review has revealed a strong imbalance in the geographic distribution of prior studies, with the majority having been conducted in developed countries and core regions. By contrast developing countries and more peripheral regions have been relatively overlooked, peripheral regions in developing economies particularly so.
Considering the multiplicity of roles performed within the RIS-University-Science park nexus, there is therefore a clear gap in the literature with respect to both university roles and potential contributions within nascent peripheral and developing economy RIS. In particular, there is a specific need to understand how universities are able to contribute to the development of RIS within developing countries, as well as identifying the activities they are less capable of performing due to shortcomings in the RIS as well as their own capabilities.
More broadly, although the university is found to be the crucial component in both RIS and science park literature, there were only a limited number of studies focused on the simultaneous roles played by the university during its relationships with these other actors. Consequently, future research needs to provide a more integrated approach to further our understanding of the simultaneous roles of universities within these relationships, which again will have specific national and regional contexts. This would also help further our understanding of the university's role as conduit between the RIS and Science Park.
Methodologically there also appeared to be relatively few studies conducted longitudinally, or comparatively. We therefore suggest a need for comparative studies to better uncover the relative influence of regional contexts, specific policies, and capabilities of Universities on the specific roles they perform. This may include analysis of Science Parks where universities are/are not present, to further understand their roles, as well as examples of science parks where universities successfully contribute versus those where universities make less of a contribution.
Finally, few studies simultaneously linked the literature on the science park with that of the RIS, identifying the necessity to examine the roles of specific universities in science parks within the context of specific RIS. Overall, this identifies the need for contextual studies to explore these roles and unpick the impact of specific local and regional government initiatives on the roles and contributions of the University. Such research would help to inform future policy to enhance science park performance and ultimately the development of RIS in a manner appropriate for a particular context.
In conclusion, whilst Universities can make several contributions within the RIS-University-Science park nexus their ability to undertake activities that are closer to the market have been found to be limited in several respects, not only because of their own limitations but also because of the wider RIS context in which they operate. The takeaway message for policymakers, universities and science park managers, therefore, is that, in the science park context, the results of this review suggest that universities will be assisting science parks to play different combinations of roles in relation to innovation, depending on the different RIS contexts in which they find themselves.
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