Activity Coefficients at Infinite Dilution and Physicochemical Properties for Organic Solutes and Water in the Ionic Liquid 1-Ethyl-3-methylimidazolium trifluorotris(perfluoroethyl)phosphate

New data of activity coefficients at infinite dilution, γ 13∞, for 65 different solutes including alkanes, alkenes, alkynes, cycloalkanes, aromatic hydrocarbons, alcohols, thiophene, ethers, ketones, aldehydes, esters and water in the ionic liquid 1-ethyl-3-methylimidazolium trifluorotris(perfluoroethyl)phosphate, were determined using inverse gas chromatography within the temperature range from 318.15 to 368.15 K. This is a continuation of our study of ionic liquids based on this anion. The results are compared with the other trifluorotris(perfluoroethyl)phosphate ionic liquids. The γ 13∞ values were used to calculate thermodynamic functions such as partial molar excess Gibbs energies \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \Delta G_{1}^{{{\text{E,}}\infty }} $$\end{document}ΔG1E,∞, enthalpies \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \Delta H_{1}^{{{\text{E,}}\infty }} $$\end{document}ΔH1E,∞ and entropies \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \Delta S_{1}^{{{\text{E,}}\infty }} $$\end{document}ΔS1E,∞ as well as gas–liquid partition coefficients of the solutes, K L. These values were used to determine the linear free energy relationship (LFER) system constants as a function of temperature. The selectivities at infinite dilution needed for some extraction problems were calculated and compared with literature data of ionic liquids based on the trifluorotris(perfluoroethyl)phosphate anion and the 1-ethyl-3-methylimidazolium cation. Additionally, the density and viscosity of the investigated ionic liquid at temperatures from 298.15 to 348.15 K were measured. Electronic supplementary material The online version of this article (doi:10.1007/s10953-014-0274-0) contains supplementary material, which is available to authorized users.


Introduction
The negligible vapor pressure of ionic liquids (ILs) makes it possible to consider ILs as environment-friendly compounds that can be used as entrainers in azeotrope breaking and fuel desulphurization, in liquid-liquid extraction processes, and in extractive distillation [1,2]. The extremely low volatility of ILs not only results in negligible solvent loss to the atmosphere, but also makes it possible to recover ILs by vacuum distillation after extraction, which is an advantage from an economic point of view. The number of azeotropes occurring in industry is large, for instance: water/alcohol systems formed in fermentation processes, alcohol/esters in esterification reactions, alcohol/aliphatic hydrocarbons in petrochemical processes as a result of using alcohols as oxygenated additives for gasolines, aromatic/aliphatic hydrocarbons, aromatic/cyclic hydrocarbons and aliphatic hydrocarbons/sulfur compounds occurring in petroleum, alcohol/ketones and water/THF formed in dehydrocyclization of 1,4-butanediol, and many others. Knowledge of the physical properties of ILs and their interaction with large number of different solvents is necessary to check their potential application in the separation of azeotropes. In addition, it allows one to determine the influence of the structure of ILs properties and consequently the tailoring of ILs for specialized applications. The almost unlimited number of possible combination of anions and cations makes this possible.
Insight into the interactions between ILs and different compounds is given by activity coefficients at infinite dilution c 13 ?
. From these data, it is possible to calculate the selectivity S 12 ? = c 13 ? /c 23 ? and capacity k 2 ? = 1/c 23 ? at infinite dilution for specific azeotropic mixtures. In this work, we continue a systematic investigation of c 13 ? for trifluorotris(perfluoroethyl)phosphate [FAP]based ILs, which indicates satisfactory values of S 12 ? and k 2 ? for many extraction problems [3][4][5][6][7][8]. In this paper we have chosen 1-ethyl-3-methylimidazolium trifluorotris(perfluoroethyl)phosphate [emim][FAP] and measure the density and the viscosity (over the temperature range of 298.15 to 348.15 K) and c 13 ? (over the temperature range of 318.15 and 368.15 K) for systems involving 65 solutes that include alkanes, alkenes, alkynes, cycloalkanes, aromatic hydrocarbons, alcohols, thiophene, ethers, aldehydes, ketones, esters, 1-nitropropane, acetonitrile and water. The determination of c 13 ? was carried out using inverse gas chromatography, a widely accepted and useful method that is particularly useful for solvents of low volatility such as ILs. Based on these values of c 13 ? , gas-liquid partition coefficients, K L , and basic thermodynamics functions, such as partial molar excess Gibbs energies DG E; Merck. This ionic liquid was further purified by subjecting the liquid to a very low pressure of about 5 9 10 -3 Pa at about 363 K for approximately 5 h. This procedure removed any volatile chemicals and water from the ionic liquid. The water content was analyzed by Karl-Fischer titration (method TitroLine KF). The sample of IL was dissolved in methanol and titrated with steps of 2.5 lL. The results obtained showed the water content was less than 200 ppm. The density was measured using an Anton Paar GmbH 4500 vibrating-tube densimeter (Graz, Austria) with an uncertainty ±1 9 10 -5 gÁcm -3 . Viscosity measurements were performed using an Anton Paar GmbH AMVn Automated Micro Viscometer (Graz, Austria) with an uncertainty ±0.1 %. The solutes, purchased from Aldrich and Fluka, were used without further purification because the IGC technique separated any impurities on the column. The list of materials with purities are presented in the Online Supplementary Material Table 1S. The structure of investigated IL is:

Apparatus and Experimental Procedure
The experiments were performed using a Perkin Elmer Clarus 500 gas chromatograph equipped with a thermal conductivity detector (TCD). The data were collected and processed using TotalChrom Workstation software. The column preparation and the packing method used in this work have been described previously [24]. Glass columns of length 1 m and 4 mm internal diameter were used. Chromosorb WHP/AW-DMCS 100/120 mesh was used as the solid support and was supplied by Sigma-Aldrich. Coating the solid support material with the ionic liquid was performed by dispersing a certain portion of Chromosorb in a solution of the ionic liquid in methanol followed by evaporation of the solvent using a rotating evaporator. The masses of the stationary phase and of the solid support were weighed with a precision ±0.0001 g. The solvent column packing varied from (45.1-50.0) mass fraction of the ionic liquid, large enough to prevent any residual adsorption of solute on the column packing. The uncertainty in the moles of the IL packed on the support is about ±3 9 10 -7 mol. Before experiments, each column was conditioned passing carrier gas through it at a flow rate (about 1.5 9 10 -6 m 3 Ás -1 ) at the high temperature (373.15 K) for about 8 h. The second column was used to check the reproducibility of results at a different packing level. On the second column, measurements were performed at two temperatures (338.15 and 358.15) K. Results from these two different columns were reproducible with errors less than 0.5 %. The pressure drop (p i -p o ) varied between (20 and 60) kPa, depending on flow rate of carrier gas. The inlet pressure p i was measured by a pressure gauge installed on the gas chromatograph with an uncertainty of ±0.1 kPa. The outlet pressure p o was measured using an Agilent Precision Gas Flow Meter with an uncertainty of ±0.07 kPa.
The carrier gas was helium. The flow rate of carrier gas was determined using an Agilent Precision Gas Flow Meter, which was placed at the outlet present after the detector, with an uncertainty of ±0.1 9 10 -6 m 3 Ámin -1 . The flow rate was set for a series of runs and was allowed to stabilize for at least 15 min before the retention times were determined. The flow rates were corrected for water vapor pressure. Solute injections ranged from 0.01 to 0.2 lL and were considered to be at infinite dilution on the column. Experiments were carried out at different temperatures (in steps of 10 K) between 318.15 and 368.15 K. The temperature of the column was maintained constant to within ±0.02 K. At a given temperature, each experiment was repeated 2-3 times to check the reproducibility. Retention times were generally reproducible within (0.001-0.01) min depending on the temperature and the individual solute. At each temperature values of the dead time t G , identical to the retention time of a non-retainable component, were measured. While our GC was equipped with a TCD detector, air was used as a non-retainable component. The estimated overall error in c 13 ? is less than 3 %, taking into account the possible errors in determining the column loading, the retention times and solute vapor pressure. The IGC technique was tested for the system hexane in hexadecane at T = 298.15 K and the results compare very favorably with the literature values [25].

Theoretical Basis
The equation developed by Everett [26] and Cruickshank et al. [27] was used in this work to calculate the c 13 ? of the solutes in the ionic liquid: The description of the equation and the other equations used in this work to calculate physicochemical properties (K L , DG E;1 1 , DH E;1  Table 2. Compounds with a longer alkyl chain have higher values of c 13 ? in the following group of solutes: alkanes, cycloalkanes, alkenes, alkynes, aromatic hydrocarbons, alcohols, esters, ethers, aldehydes and ketones. The highest c 13 ? are for alkanes, indicating weak interactions between this series of homologous compounds and [emim] [FAP]. Lower values of c 13 ? are observed for the corresponding substances having p-electrons in their chemical structure. It can be seen that interactions between the IL and a solute increase with increasing number of p-electrons in the structure (values of c 13 ? take the order: alkenes [ alkynes [ aromatic hydrocarbons). It is worth noticing that benzene has c 13 ? values that are below 1, while the remaining investigated aromatic hydrocarbons have c 13 ? values close to unity. Cyclization and isomerization in the structure of a solute results a decrease of the c 13 ? values and an increase in the solubility in IL in comparison to alkanes with the same number of carbon atoms. This is probably due to a packing effect and a smaller molar volume. The same effect is present for primary, secondary and tertiary alcohols, ethers and branches ethers. The presence of oxygen, nitrogen, or sulfur atoms in the structure of polar solute compounds leads to high interactions with [emim] [FAP]. The lowest values of c 13 ? (below 1) are for thiophene, pyridine, esters, tetrahydrofuran, 1,4-dioxane, ketones, aldehydes, acetonitrile and 1-nitropropane. Higher c 13 ? values are seen for alcohols, water and ethers. For example the c 13 ? value for di-n-butyl ether is even greater than 9. Table 3 shows the gas-liquid partition coefficients K L of solutes calculated from measured c 13 ? and densities for [emim] [FAP]. These values decrease with increasing temperature in all cases and increase with increasing alkyl chain length for all of the investigated groups of solutes. The highest value was observed for 1-nitropropane. Other determined thermodynamic functions, namely partial molar excess Gibbs energies DG E;1 1 , enthalpies DH E;1 1 and entropies DS E;1 1 at infinite dilution are presented at temperature 328.15 K in Table 4. Alkynes, aromatic hydrocarbons, thiophene, pyridine, esters, ethers, ketones, aldehydes, acetonitrile and 1-nitropropane reveal stronger interactions between the IL and the solute pairs than between the solutes themselves, which show negative values of DH E;1 1 . The exceptions are oct-1-yne and di-n-butyl ether with positive DH E;1 1 Table 1 Density, q, and viscosity, g, as a function of temperature, T, for ionic liquid [emim][FAP] at pressure p = 0.1 MPa Standard uncertainties u are u(T) = ±(0.01 and 0.05) for q and g, respectively,   ) \ ±3 %, u(T) = ±0.02 K     are seen for alcohols and water, which indicates a breaking of hydrogen bonds during the dissolution process.  Table 2S. Moreover, previously published data for [emim][FAP] are also presented in Fig. 1 [21].

The IL investigated in this work, [emim][FAP], reveals higher values of c 13
? than the IL [hmim] [FAP], for all compared solutes. The difference is greater in the case of alkanes, alkenes, alkynes, cycloalkanes and aromatic hydrocarbons. This is no doubt caused by the stronger interactions between IL and the more non-polar alkyl chain and non-polar compounds. The IL [C 2 OHmim][FAP], with its polar hydroxyl group, has the highest c 13 ? values for non-polar aliphatic and aromatic hydrocarbons and the lowest ones for polar compounds.
In comparison with work of Yan et al. [21], our results are higher than those obtained previously for alkanes. This difference decreases with increasing alkyl chain length. The c 13 ? values obtained in this work are also higher for cyclohexane and hex-1-ene but comparable for oct-1-ene and dec-1-ene. In the case of alkynes our results show slightly higher The typical behavior for these systems involving imidazolium ILs is that the selectivity, related to the hexane/benzene system, decreases with increasing of number of carbons in the alkyl side-chain. This can be seen in Fig. 2 [10,11,14,18,21,22,[29][30][31][32][33][34][35][36][37][38][39]. The reason for this is that the longer the non-polar alkyl chain, the stronger will be the van der Waals interactions with hexane and benzene, thus reducing the difference between IL-hexane and IL-benzene selectivities. Moreover, the longer the alkyl chains are, the more they inhibit the p-p interactions between the aromatic ring of benzene and the imidazole center as a result of steric hinderance. Figure 3  . This means that the imidazolium cation interacts much more strongly than with benzene and thiophene than do ILs based on pyrrolidinium and piperidinium despite the presence of the methoxy groups in their structures. ? , at T = 328.15 K for ionic liquids based on [emim] ? cation for separation: (filled circle) hexane/ benzene [10-15, 17, 18, 20]; (empty circle) cyclohexane/ benzene [9][10][11][12][13][14][15][16][17][18][19][20], (empty square) heptane/thiophene [11,15,17,19]. The lines are drawn to guide the eye  The Abraham solvation parameter model [40]: gives an estimation of K L for additional solutes in [COC 2 mPIP][NTf 2 ]. The independent variables in Eq. 2 are solute descriptors described previously [40][41][42]: E is the solute excess molar refraction, S is the solute dipolarity/polarizability, A and B are the overall or summation of solute hydrogen bond acidity and basicity, and L is the logarithm of the gashexadecane partition coefficient at T = 298 K. Solute descriptors are available for wide range of compounds. The six regression coefficients (c, e, s, a, b and l) relate to the properties of the solvent phase and are determined by regression analysis from experimental K L values. The c coefficient is the model constant taking into account opposing contributions of different effects: e-interactions with lone pair electrons, s -dipole-type interactions, a and b-the hydrogen-bond basicity and acidity of the stationary phase respectively, and l-cavity formation and dispersion interactions. The linear solvation energy relationship (LFER) system constants as a function of temperature for ionic liquid investigated in this work are presented in the Table 5.

Conclusions
Activity coefficients at infinite dilution and the gas-liquid partition coefficients for 65 solutes in the ionic liquid 1-ethyl-3-methylimidazolium trifluorotris(perfluoroethyl)phosphate were measured by inverse gas chromatography at temperatures ranging from 318. 15