Skip to main content
SpringerLink
Log in

Hollow mesoporous carbon nanospheres from self-generating dual template synergetic assembly for enhanced curcumin release

  • Published:
Journal of Porous Materials Aims and scope Submit manuscript

Abstract

Hollow mesoporous carbon nanospheres with accessible interior cavity, short diffusion length, and abundant mesopore channels can favor guest encapsulation and facilitate mass diffusion and transfer. However, there still remains great challenge in controllable synthesizing mesoporous carbons with uniform hollow architectures and relatively large mesopores by a straightforward method. Herein, a self-generating dual template synergetic assembly strategy was developed to construct hollow structured nitrogen-doped mesoporous carbon nanospheres (NMCNs) for the first time. Differentiating from conventional emulsion template methods, this synthesis involved the generation of nanoemulsion, which was driven by the interaction between oleic acid and triethanolamine based on the newborn soap effect. The process from alkalic to acidic environment induced the polymerization of the 3D cross-linking framework and established coulomb forces for dual template synergetic assembly. Significantly, the inner-cavity size of NMCNs could be facilely changed by simply varying the addition of oleic acid. Furthermore, varying the ethanol/water volume ratio would regulate the surface roughness of the NMCNs by directing the polymerization mode. This method innovatively coupled the dual template strategy and emulsion polymerization system, providing new insight into the construction of hollow mesoporous materials. Impressively, the hollow NMCNs featured dual pore size (5.2, 8.6 nm), high surface area (≈ 723.48 m2/g), and high nitrogen content (12.24 wt%), which delivered enhanced release rate and in vitro bioactivity of insoluble drug curcumin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. S. Feng, J. Lu, K. Wang, D. Di, Z. Shi, Q. Zhao, S. Wang, Chem. Eng. J. 435, 134886 (2022)

    Article  CAS  Google Scholar 

  2. W. Sun, K. Guo, J. Fan, Y. Min, Q. Xu, ACS Appl. Mater. Interfaces 13, 16558–16566 (2021)

    Article  CAS  PubMed  Google Scholar 

  3. L. Zu, W. Zhang, L. Qu, L. Liu, W. Li, A. Yu, D. Zhao, Adv. Energy Mater. 10, 2002152 (2020)

    Article  CAS  Google Scholar 

  4. X. Hu, J. Li, G. Zhong, Y. Liu, J. Yuan, S. Lei, H. Zhan, Z. Wen Small 16, e2005534 (2020)

  5. X. Zhu, Y. Xia, X. Zhang, A.A. Al-Khalaf, T. Zhao, J. Xu, L. Peng, W.N. Hozzein, W. Li, D. Zhao, J. Mater. Chem. A 7, 8975–8983 (2019)

    Article  CAS  Google Scholar 

  6. G.H. Wang, J. Hilgert, F.H. Richter, F. Wang, H.J. Bongard, B. Spliethoff, C. Weidenthaler, F. Schuth, Nat. Mater. 13, 293–300 (2014)

    Article  PubMed  Google Scholar 

  7. T. Meng, A. Nsabimana, Z. Liu, H. Jia, S. An, H. Wang, Y. Zhang, J. Colloid Interface Sci. 579, 12–20 (2020)

    Article  CAS  PubMed  Google Scholar 

  8. J. Liang, H. Kou, S. Ding, Adv. Funct. Mater. 31, 2007801 (2020)

    Article  Google Scholar 

  9. L. Peng, H. Peng, C. Hung, D. Guo, L. Duan, B. Ma, L. Liu, W. Li, D. Zhao, Chem 7, 1020–1032 (2021)

    Article  CAS  Google Scholar 

  10. Y. Li, J. Shi, Adv. Mater. 26, 3176–3205 (2014)

    Article  CAS  PubMed  Google Scholar 

  11. D.S. Bin, Y.S. Xu, S.J. Guo, Y.G. Sun, A.M. Cao, L.J. Wan, Acc. Chem. Res. 54, 221–231 (2021)

    Article  CAS  PubMed  Google Scholar 

  12. H. Lin, W. Ye, Y. Liu, M. Liu, C. Song, H. Zhang, R. Lu, S. Zhang, J. Mater. Chem. A 8, 1221–1228 (2020)

    Article  CAS  Google Scholar 

  13. R. Zhao, H. Wang, N. Gao, R. Liu, T. Guo, J. Wu, T. Zhang, J. Li, J. Du, T. Asefa, Small Methods 4, 3195–3201 (2019)

    Google Scholar 

  14. T. Wang, Y. Sun, L. Zhang, K. Li, Y. Yi, S. Song, M. Li, Z.A. Qiao, S. Dai, Adv. Mater. 31, 1807876 (2019)

    Article  Google Scholar 

  15. A. Lu, T. Sun, W. Li, Q. Sun, F. Han, D. Liu, Y. Guo, Angew Chem. Int. Ed. 50, 11765–11768 (2011)

    Article  CAS  Google Scholar 

  16. B. Liu, H.C. Zeng, Small 1, 566–571 (2005)

    Article  CAS  PubMed  Google Scholar 

  17. J. Cheng, Y. Liu, X. Zhang, X. Miao, Y. Chen, S. Chen, J. Lin, Y. Zhang, Chem. Eng. J. 419, 129649 (2021)

    Article  CAS  Google Scholar 

  18. C. Liu, J. Wang, J. Li, M. Zeng, R. Luo, J. Shen, X. Sun, W. Han, L. Wang, ACS Appl. Mater. Interfaces 8, 7194–7204 (2016)

    Article  CAS  PubMed  Google Scholar 

  19. F. Caruso, R.A. Caruso, H. Mohwald, Science 282, 1111–1114 (1998)

    Article  CAS  PubMed  Google Scholar 

  20. F. Su, X.S. Zhao, Y. Wang, L. Wang, J.Y. Lee, J. Mater. Chem. 16, 4413–4419 (2006)

    Article  CAS  Google Scholar 

  21. J. Du, L. Liu, B. Liu, Y. Yu, H. Lv, A. Chen, Carbon 143, 467–474 (2019)

    Article  CAS  Google Scholar 

  22. Y. Xia, X. Na, J. Wu, G. Ma, Adv. Mater. 31, 1801159 (2018)

    Article  Google Scholar 

  23. X. Yang, P. Lu, L. Yu, P. Pan, A.A. Elzatahry, A. Alghamdi, W. Luo, X. Cheng, Y. Deng, Adv. Funct. Mater. 30, 2002488 (2020)

    Article  CAS  Google Scholar 

  24. T. Zhou, Y. Zhou, R. Ma, Z. Zhou, G. Liu, Q. Liu, Y. Zhu, J. Wang, Carbon 114, 177–186 (2017)

    Article  CAS  Google Scholar 

  25. X. Du, C. Zhao, M. Zhou, T. Ma, H. Huang, M. Jaroniec, X. Zhang, S. Qiao, Small 13, 1602592 (2017)

    Article  Google Scholar 

  26. L. Sun, Y. Wang, T. Jiang, X. Zheng, J. Zhang, J. Sun, C. Sun, S. Wang, ACS Appl. Mater. Interfaces 5, 103–113 (2013)

    Article  CAS  PubMed  Google Scholar 

  27. X. Wang, Y. He, C. Liu, Y. Liu, Z. Qiao, Q. Huo, Nanoscale 8, 13581–13588 (2016)

    Article  CAS  PubMed  Google Scholar 

  28. C. Rao, X. Guo, M. Li, X. Sun, X. Lian, H. Wang, X. Gao, B. Niu, W. Li, J. Mater. Sci. 54, 11243–11253 (2019)

    Article  CAS  Google Scholar 

  29. W. Huang, J. Chong, Y. Tian, X. Wang, Chem. Eng. J. 327, 18–27 (2017)

    Article  CAS  Google Scholar 

  30. R.P. Sear, J. Phys. Condens. Matter 19, 203–206 (2007)

    Google Scholar 

  31. H. Xie, Y. Zhao, Y. Tian, X. Wang, M. Yan, Carbon 152, 295–304 (2019)

    Article  CAS  Google Scholar 

  32. W. Huang, H. Xie, Y. Tian, X. Wang, ACS Appl. Mater. Interfaces 10, 20073–20084 (2018)

    Article  CAS  PubMed  Google Scholar 

  33. D. Guo, Y. Fu, F. Bu, H. Liang, L. Duan, Z. Zhao, C. Wang, A.M. El-Toni, W. Li, D. Zhao, Small Methods 5, 2001137 (2021)

    Article  CAS  Google Scholar 

  34. B. Friedel, S. Greulich-Weber, Small 2, 859–863 (2006)

    Article  CAS  PubMed  Google Scholar 

  35. F. Ma, H. Zhao, L. Sun, Q. Li, L. Huo, T. Xia, S. Gao, G. Pang, Z. Shi, S. Feng, J. Mater. Chem. 22, 13464–13468 (2012)

    Article  CAS  Google Scholar 

  36. J. Zhou, J. Lian, L. Hou, J. Zhang, H. Gou, M. Xia, Y. Zhao, T.A. Strobel, L. Tao, F. Gao, Nat. Commun. 6, 8503 (2015)

    Article  CAS  PubMed  Google Scholar 

  37. W.J. Lee, J. Lim, S.O. Kim, Small Methods 1, 1600014 (2017)

    Article  Google Scholar 

  38. F. Xu, Y. Zhai, E. Zhang, Q. Liu, G. Jiang, X. Xu, Y. Qiu, X. Liu, H. Wang, S. Kaskel, Angew Chem. Int. Ed. 59, 19460–19467 (2020)

    Article  CAS  Google Scholar 

  39. Y. Li, J. Qi, J. Li, J. Shen, Y. Liu, X. Sun, J. Shen, W. Han, L. Wang, ACS Sustain. Chem. Eng. 5, 6635–6644 (2017)

    Article  CAS  Google Scholar 

  40. F. Feltrin, T. Agner, C. Sayer, L. Lona, Adv. Colloid Interface Sci. 300, 102582 (2022)

    Article  CAS  PubMed  Google Scholar 

  41. S. Bose, A.K. Panda, S. Mukherjee, G. Sa, Cell. Div. 10, 6 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  42. V.S. Bollu, A.K. Barui, S.K. Mondal, S. Prashar, M. Fajardo, D. Briones, A. Rodriguez-Dieguez, C.R. Patra, S. Gomez-Ruiz, Mater. Sci. Eng. C Mater. Biol. Appl. 63, 393–410 (2016)

    Article  CAS  PubMed  Google Scholar 

  43. M. Mahjoob, U. Stochaj, Ageing Res. Rev. 69, 101364 (2021)

    Article  CAS  PubMed  Google Scholar 

  44. S. Jambhrunkar, Z. Qu, A. Popat, J. Yang, O. Noonan, L. Acauan, Y. Ahmad Nor, C. Yu, S. Karmakar, Mol. Pharm. 11, 3642–3655 (2014)

    Article  CAS  PubMed  Google Scholar 

  45. S. Peng, Z. Li, L. Zou, W. Liu, C. Liu, D. McClements, Food Funct. 9, 1829–1839 (2018)

    Article  CAS  PubMed  Google Scholar 

  46. X. Wang, H. Pan, Q. Lin, H. Wu, S. Jia, Y. Shi, Nanoscale Res. Lett. 14, 259 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  47. T. Husain, M.H. Shoaib, F.R. Ahmed, R.I. Yousuf, S. Farooqi, F. Siddiqui, M.S. Imtiaz, M. Maboos, S. Jabeen, Int. J. Nanomed. 16, 1725–1741 (2021)

    Article  Google Scholar 

  48. J. Goscianska, A. Olejnik, A. Ejsmont, A. Galarda, S. Wuttke, J. Colloid Interface Sci. 586, 673–682 (2021)

Download references

Acknowledgements

This work was financially supported by the Guangdong Basic and Applied Basic Research Foundation (2022A1515011225, 2021A1515010334), and the Medicinal Research Fund of Guangdong Province (A2022234).

Author information

Authors and Affiliations

  1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Zaisheng Zhu, Xiaoxi Zhao, Yujie Liu, Yong Tian & Xiufang Wang

Authors
  1. Zaisheng Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaoxi Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yujie Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yong Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiufang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

The date collection and analysis were performed by ZZ and XZ; the main manuscript text was written by XZ; this manuscript was revised by YL, YT, and XW; the financial support for the experiment was provided by ZZ, YT, and XW. All authors reviewed the manuscript.

Corresponding author

Correspondence to Xiufang Wang.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary Material 1

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhu, Z., Zhao, X., Liu, Y. et al. Hollow mesoporous carbon nanospheres from self-generating dual template synergetic assembly for enhanced curcumin release. J Porous Mater 30, 363–376 (2023). https://doi.org/10.1007/s10934-022-01348-5

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10934-022-01348-5

Keywords

Search

Navigation