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Preparation of Metal–Organic Frameworks UiO-66 for Adsorptive Removal of Methotrexate from Aqueous Solution

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Abstract

A low cytotoxic metal–organic framework (MOF) UiO-66 (UiO stands for University of Oslo) and NH2-UiO-66, that showed high cell viability of HFF-2 via 3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyl tetrazolium assay, was reported as an effective adsorbent (antidotal) agents. The structure of MOFs was confirmed by Fourier transform infrared, Field emission scanning electron microscopy (FESEM) and X-ray diffraction. Thermal behavior of MOFs was investigated using with thermogravimetric analyzer in nitrogen atmosphere to check the thermal stability. FESEM showed NH2-UiO-66 displayed symmetrical crystals with triangular base pyramid morphology, with the particle size around 100 nm and uniform size distribution. The specific surface areas were calculated using the Brunauer–Emmett–Teller method and surface area and total pore volume of NH2-UiO-66 were calculated to be 1258 m2/g and 0.51 cm3/g, respectively. Methotrexate salt (MTX) was selected as the model drug which was adsorbed into inner pores and channels of MOFs by diffusion manner. The interaction between MOFs and MTX and the effect of pH on interaction between them in aqueous solution was investigated. The final results showed that UiO-66 have high adsorbing capacity and great affinity to MTX.

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Acknowledgements

This study was supported financially by Zanjan University of medical science and Sharif University of Technology, Iran.

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Authors and Affiliations

  1. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

    Mozhgan Aghajanzadeh & Mostafa Zamani

  2. Institute for Nanoscience and Nanotechnology (INST), Sharif University of Technology, Tehran, Iran

    Hossein Molavi

  3. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

    Hamidreza Khieri Manjili & Hossein Danafar

  4. Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

    Hamidreza Khieri Manjili

  5. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

    Hossein Danafar

  6. Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

    Hossein Danafar

  7. Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

    Hossein Danafar

  8. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran

    Akbar Shojaei

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  1. Mozhgan Aghajanzadeh
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  2. Mostafa Zamani
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Correspondence to Hossein Danafar or Akbar Shojaei.

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Aghajanzadeh, M., Zamani, M., Molavi, H. et al. Preparation of Metal–Organic Frameworks UiO-66 for Adsorptive Removal of Methotrexate from Aqueous Solution. J Inorg Organomet Polym 28, 177–186 (2018). https://doi.org/10.1007/s10904-017-0709-3

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  • DOI: https://doi.org/10.1007/s10904-017-0709-3

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