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A Dual-emitting Two-dimensional Nickel-based Metal-organic Framework Nanosheets: Eu3+/Ag+ Functionalization Synthesis and Ratiometric Sensing in Aqueous Solution

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Abstract

Using two-dimensional (2D) nickel-based metal organic framework (Ni-MOF) nanosheets as a matrix, Eu3+ and Ag+ were incorporated to synthesize Ag/Eu@Ni-MOF with double luminescence centers of Eu3+ ion (615 nm) and organic ligand (524 nm). And a ratiometric luminescence sensor is constructed based on Ag/Eu@Ni-MOF for sensitive detection of biothiols in aqueous solutions. The dual-emissive fluorescence properties can be tuned by changing the amounts of Ag+ ions doping. The results of temperature and pH effects on the fluorescence of Ag/Eu@Ni-MOF indicates that the Ag/Eu@Ni-MOF is a temperature-sensitive material and the fluorescence of Ag/Eu@Ni-MOF can keep stable over a wide pH range. Due to the binding of -SH in cysteine (Cys) and glutathione (GSH) with Ag+, the ligand luminescence was significantly inhibited by weakening the Ag + influence on the energy transfer process in the MOFs. Therefore, ratiometric fluorescent sensing of biomolecular thiols was realized based on the dual-emission Ag/Eu@Ni-MOF. More importantly, the fluorescence color change can be observed with naked eyes to realize visual detection. The ratiometric fluorescent sensor exhibits high performance for Cys and GSH detection with a wide linear range of 5-250 µM and a relatively low detection limit of 0.20 µM and 0.17 µM, respectively. Furthermore, the biothiols content in human serum was determined with satisfactory results. It proves the Ni-MOF nanosheets can be used as a stable matrix for construction luminescent MOFs for the first time, and validate the great potential of Ag/Eu@Ni-MOF as a ratiometric fluorescent probe for point-of-care testing (POCT) in disease diagnosis.

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Acknowledgements

We gratefully acknowledge the financial support from the NSFC (Nos. 21705141, 22076161, 21675140, 21575124), the Green Yang Jinfeng Talent Project of Yangzhou.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Yangzhou University, 225002, Yangzhou, China

    Yun Shu, Tao Dai, Qiuyu Ye, Qin Xu & Xiaoya Hu

  2. Department of Chemical Engineering, Yangzhou Polytechnic Institute, 225127, Yangzhou, China

    Dangqin Jin

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  1. Yun Shu
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Contributions

Yun Shu: Conceptualization, Supervision, Methodology, Writing–review & editing, Project administration. Tao Dai: Conceptualization, Methodology, Writing-original draft, Formal analysis. Qiuyu Ye: Data curation, Investigation. Dangqin Jin: Investigation. Qin Xu: Visualization, Investigation. Xiaoya Hu: Supervision, Funding acquisition.

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Correspondence to Yun Shu or Xiaoya Hu.

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Shu, Y., Dai, T., Ye, Q. et al. A Dual-emitting Two-dimensional Nickel-based Metal-organic Framework Nanosheets: Eu3+/Ag+ Functionalization Synthesis and Ratiometric Sensing in Aqueous Solution. J Fluoresc 31, 1947–1957 (2021). https://doi.org/10.1007/s10895-021-02826-w

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