Skip to main content

Advertisement

SpringerLink
Log in

TRECs/KRECs: Beyond the Diagnosis of Severe Combined Immunodeficiency

  • Letter to Editor
  • Published:
Journal of Clinical Immunology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data Availability

Not applicable. No datasets were generated or analyzed during the preparation of the manuscript.

References

  1. Dasouki M, Jabr A, AlDakheel G, Elbadaoui F, Alazami AM, Al-Saud B, et al. TREC and KREC profiling as a representative of thymus and bone marrow output in patients with various inborn errors of immunity. Clin Exp Immunol. 2020;202:60–71.

    Article  CAS  Google Scholar 

  2. Remaschi G, Ricci S, Cortimiglia M, De Vitis E, Iannuzzi L, Boni L, et al. TREC and KREC in very preterm infants: reference values and effects of maternal and neonatal factors. J Matern Fetal Neonatal Med. 2019;34(23):3946–51.

    Article  Google Scholar 

  3. Truck J, Prader S, Natalucci G, Hagmann C, Brotschi B, Kelly J, et al. Swiss newborn screening for severe T and B cell deficiency with a combined TREC/KREC assay – management recommendations. Swiss Med Wkly. 2020;150:w20254.

    Article  Google Scholar 

  4. King JR, Hammarström L. Newborn screening for primary immunodeficiency diseases: history, current and future practice. J Clin Immunol. 2018;38(1):56–66.

    Article  CAS  Google Scholar 

  5. Brown PA. Neonatal leukemia. Clin Perinatol. 2021;48:15–33.

    Article  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge the support from Edgar Borges de Oliveira Junior from Immunogenic Inc. responsible for the laboratory assessment of the NBS tests. We also thank all members of the Brazilian Cooperative Group for Myelodysplastic Syndrome in Pediatrics, Amor Hospital, Barretos for the definitive diagnosis. We acknowledge Dr. Ana Virginia Lopes de Sousa and her team from the Support Group for Adolescents and Children with Cancer – Pediatric Oncologic Institute (GRAACC – IOP) for treatment care.

Author information

Authors and Affiliations

  1. Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil

    Barbara Cristina Ramos, Carolina Sanchez Aranda, Amanda Oliveira Sobrinho & Dirceu Sole

  2. Department of Immunology, University of São Paulo, São Paulo, Brazil

    Antonio Condino-Neto

Authors
  1. Barbara Cristina Ramos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carolina Sanchez Aranda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Amanda Oliveira Sobrinho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dirceu Sole
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Antonio Condino-Neto
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the preparation and concept of the manuscript. BCR, AS, and CA participated in data collection and writing of the draft. CA, DS, and ACN reviewed the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Barbara Cristina Ramos.

Ethics declarations

Ethics Approval

The study was conducted in accordance with the principles of the Declaration of Helsinki. The Ethics Committee of the Federal University of Sao Paulo approved this study (0337/2021).

Consent to Participate

Informed consent was obtained from the parents.

Consent for Publication

Parents consented to the publication.

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ramos, B.C., Aranda, C.S., Sobrinho, A.O. et al. TRECs/KRECs: Beyond the Diagnosis of Severe Combined Immunodeficiency. J Clin Immunol 43, 80–81 (2023). https://doi.org/10.1007/s10875-022-01363-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10875-022-01363-w

Keywords

Search

Navigation