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Evaluation of a multi-layer microbraided polylactic acid fiber-reinforced conduit for peripheral nerve regeneration

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Abstract

We evaluated peripheral nerve regeneration using a biodegradable multi-layer microbraided polylactic acid (PLA) fiber-reinforced conduit. Biodegradability of the PLA conduit and its effectiveness as a guidance channel were examined as it was used to repair a 10 mm gap in the rat sciatic nerve. As a result, tube fragmentation was not obvious and successful regeneration through the gap occurred in all the conduits at 8 weeks after operation. These results indicate the superiority of the PLA materials and suggest that the multi-layer microbraided PLA fiber-reinforced conduits provide a promising tool for neuro-regeneration.

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Acknowledgements

The authors would like to thank National Science Council of the Republic of China (Contract No. 96-2628-E-039-011-MY3, 96-2622-E-039-001-CC3) for financially supporting this research. Dr. Tsai-Chung Lee is appreciated for her assistance in analyzing the data.

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Authors and Affiliations

  1. School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan

    Ming-Chin Lu

  2. Laboratory of Biomaterials, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan

    Yen-Ting Huang, Chun-Hsu Yao & Yueh-Sheng Chen

  3. Laboratory of Fiber Application and Manufacturing, Graduated Institute of Textile Engineering, Feng Chia University, Taichung, Taiwan

    Jia-Horng Lin

  4. Institute of Biomedical Engineering and Material Science, Central Taiwan University of Science and Technology, Taichung, Taiwan

    Ching-Wen Lou

  5. Department of Biological Science & Technology, I-Su University, Kaohsiung, Taiwan

    Chin-Chuan Tsai

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  1. Ming-Chin Lu
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  2. Yen-Ting Huang
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  4. Chun-Hsu Yao
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Correspondence to Ming-Chin Lu.

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Ming-Chin Lu, Chun-Hsu Yao, and Yueh-Sheng Chen are contributed equally to this work.

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Lu, MC., Huang, YT., Lin, JH. et al. Evaluation of a multi-layer microbraided polylactic acid fiber-reinforced conduit for peripheral nerve regeneration. J Mater Sci: Mater Med 20, 1175–1180 (2009). https://doi.org/10.1007/s10856-008-3646-4

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  • DOI: https://doi.org/10.1007/s10856-008-3646-4

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