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ZIF-8 derived Ni(OH)2 hollow nanocages for non-enzymatic glucose electrochemical sensing

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Abstract

The rational design of efficient electrocatalysts with favorable electronic structures and geometries can significantly influence their analytical performance for non-enzymatic glucose detection. In this work, nickel hydroxide nanocages on nickel foam (Ni(OH)2 NCs/NF) were fabricated by an ion-assisted etching method using zinc-based imidazole zeolite framework (ZIF-8) as a structural template. Due to the hollow nanocage structure of Ni(OH)2 NCs/NF, more exposed active sites and larger void space were obtained. The prepared hollow Ni(OH)2 NCs were used as a working electrode for electrochemical sensing glucose with high electro-catalysis performance under alkaline conditions. Under the optimal conditions, the Ni(OH)2 NCs/NF presents a short response time (less than 3 s) and a wide linear range from 1 μM to 3.45 mM for glucose assay. A low detection of limit (LOD) of 0.1 μM (S/N = 3) and an excellent sensitivity of 7413 μA mM−1 cm−2 were obtained by the prepared non-enzymatic electrochemical glucose sensor. In addition, the constructed Ni(OH)2 NCs exhibits good long-term stability and high selectivity for glucose detection. The practicability of the proposed sensor was verified by detecting glucose in serum samples with satisfactory results.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 21605108, and 81603291) and Sichuan Science and Technology Program (2022NSFSC1339). We acknowledge Qiuyue Yu and Haiyan Yang for their technical assistance in this work

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Authors and Affiliations

  1. College of Chemistry and Material Science, Sichuan Normal University, Chengdu, 610068, Sichuan, China

    Feng Xu, Kelin Hu, Siyuan Wang, Xu Chen, Rujuan Xu, Xiaoli Xiong & Ke Huang

  2. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan, China

    Xin Yuan & Mei Zhang

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  1. Feng Xu
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  2. Kelin Hu
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  3. Siyuan Wang
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Xu, F., Hu, K., Wang, S. et al. ZIF-8 derived Ni(OH)2 hollow nanocages for non-enzymatic glucose electrochemical sensing. J Mater Sci 57, 18589–18600 (2022). https://doi.org/10.1007/s10853-022-07771-y

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