Abstract
In a recent journal article, Chen et al. identified a germ cell-specific cofactor, STYXL1, associated with male fertility function. Deletion of STYXL1 prevents the LEGO player CCT complex from properly folding key microtubule proteins of the sperm flagellum, which affects sperm motility and male fertility function.
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Data availability is not applicable to this article as no new data were created or analyzed in this study.
Abbreviations
- CCT:
-
Chaperonin-containing T-complex
- MT:
-
Microtubule
- PTP:
-
Protein tyrosine phosphatases
- TEM:
-
Transmission electron microscopy
- PAS:
-
Periodic acid-Schiff
- MMAF:
-
Multiple morphological abnormality of the flagellum
- TRIC:
-
T-complex protein ring complex (otherwise known as CCT)
- ODF:
-
Outer dense fiber
- CP:
-
Central microtubule pair
References
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Acknowledgements
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Funding
This work and related studies were supported by the Natural Science Foundation of Zhejiang Province (grant No. Y20H270024) and the Zhejiang Traditional Chinese Medicine Administration (grant No. 2022ZZ017).
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Yang Xuan wrote the manuscript. Yue Duan revised the manuscript. All authors contributed to the article and approved the submitted version.
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Xuan, Y., Duan, Y. Achilles’ heel of male infertility: good LEGO players. J Assist Reprod Genet (2024). https://doi.org/10.1007/s10815-024-03122-9
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DOI: https://doi.org/10.1007/s10815-024-03122-9