Abstract
The Modified Checklist for Autism in Toddlers, Revised with Follow-up was validated on a population sample in Reykjavik, Iceland. The participants (N = 1585) were screened in well-child care at age 30 months and followed up for at least 2 years to identify autism cases. The sensitivity, specificity, positive and negative predictive values were 0.62, 0.99, 0.72, and 0.99, respectively. True-positive children were diagnosed 10 months earlier than false-negative children. Autism symptom severity and the proportions of children with verbal and performance IQs/DQs < 70 were similar between groups. Although the sensitivity was suboptimal, the screening contributed to lowering the age at diagnosis for many children. Adding autism-specific screening to the well-child care program should be considered.
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References
Akechi, H., Senju, A., Uibo, H., Kikuchi, Y., Hasegawa, T., & Hietanen, J. K. (2013). Attention to eye contact in the West and East: Autonomic responses and evaluative ratings. PLoS ONE, 8(3), e59312. https://doi.org/10.1371/journal.pone.0059312
Bacon, E. C., Courchesne, E., Barnes, C. C., Cha, D., Pence, S., Schreibman, L., et al. (2018). Rethinking the idea of late autism spectrum disorder onset. Development and Psychopathology, 30(2), 553–569. https://doi.org/10.1017/s0954579417001067
Baio, J., Wiggins, L., Christensen, D. L., Maenner, M. J., Daniels, J., Warren, Z., et al. (2018). Prevalence of autism spectrum disorder among children aged 8 years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. MMWR: Surveillance Summaries, 67(6), 1–23. https://doi.org/10.15585/mmwr.ss6706a1
Bayley, N. (2006). Bayley Scales of Infant and Toddler Development, Third Edition. Harcourt Assessment.
Bejarano-Martín, Á., Canal-Bedia, R., Magán-Maganto, M., Fernández-Álvarez, C., Jónsdóttir, S. L., Saemundsen, E., et al. (2020a). Efficacy of focused social and communication intervention practices for young children with autism spectrum disorder: A meta-analysis. Early Childhood Research Quarterly, 51, 430–445. https://doi.org/10.1016/j.ecresq.2020.01.004
Bejarano-Martín, Á., Canal-Bedia, R., Magán-Maganto, M., Fernández-Álvarez, C., Martín-Cilleros, M. V., Sánchez-Gómez, M. C., et al. (2020b). Correction to: Early detection, diagnosis and intervention services for young children with autism spectrum disorder in the European Union (ASDEU): Family and professional perspectives. Journal of Autism and Developmental Disorders, 50(9), 3380–3394. https://doi.org/10.1007/s10803-019-04253-0
Brennan, L., Fein, D., Como, A., Rathwell, I. C., & Chen, C. M. (2016). Use of the Modified Checklist for Autism, Revised with Follow up-Albanian to screen for ASD in Albania. Journal of Autism and Developmental Disorders, 46(11), 3392–3407. https://doi.org/10.1007/s10803-016-2875-5
Brigance, A. H. (2017). BRIGANCE Þroskaskimun fyrir 2½ árs börn, EPS II [BRIGANCE, Early Preschool Screen II]. Embætti landlæknis.
Canal-Bedia, R., Garcia-Primo, P., Martin-Cilleros, M. V., Santos-Borbujo, J., Guisuraga-Fernandez, Z., Herraez-Garcia, L., et al. (2011). Modified Checklist for Autism in Toddlers: Cross-cultural adaptation and validation in Spain. Journal of Autism and Developmental Disorders, 41(10), 1342–1351. https://doi.org/10.1007/s10803-010-1163-z
Canu, D., Van der Paelt, S., Canal-Bedia, R., Posada, M., Vanvuchelen, M., & Roeyers, H. (2020). Early non-social behavioural indicators of autism spectrum disorder (ASD) in siblings at elevated likelihood for ASD: A systematic review. European Child and Adolescent Psychiatry. https://doi.org/10.1007/s00787-020-01487-7
Carbone, P. S., Campbell, K., Wilkes, J., Stoddard, G. J., Huynh, K., Young, P. C., et al. (2020). Primary care autism screening and later autism diagnosis. Pediatrics, 146(2), e20192314. https://doi.org/10.1542/peds.2019-2314
Charman, T., & Baird, G. (2002). Practitioner review: Diagnosis of autism spectrum disorder in 2- and 3-year-old children. Journal of Child Psychology and Psychiatry and Allied Disciplines, 43(3), 289–305
Chawarska, K., Klin, A., Paul, R., & Volkmar, F. (2007). Autism spectrum disorder in the second year: Stability and change in syndrome expression. Journal of Child Psychology and Psychiatry and Allied Disciplines, 48(2), 128–138. https://doi.org/10.1111/j.1469-7610.2006.01685.x
Cortina, J. M. (1993). What is coefficient alpha? An examination of theory and applications. Journal of Applied Psychology, 78(1), 98–104. https://doi.org/10.1037/0021-9010.78.1.98
Crane, L., Chester, J. W., Goddard, L., Henry, L. A., & Hill, E. (2016). Experiences of autism diagnosis: A survey of over 1000 parents in the United Kingdom. Autism, 20(2), 153–162. https://doi.org/10.1177/1362361315573636
Davidovitch, M., Levit-Binnun, N., Golan, D., & Manning-Courtney, P. (2015). Late diagnosis of autism spectrum disorder after initial negative assessment by a multidisciplinary team. Journal of Developmental and Behavioral Pediatrics, 36(4), 227–234. https://doi.org/10.1097/dbp.0000000000000133
Dawson, G., Jones, E. J., Merkle, K., Venema, K., Lowy, R., Faja, S., et al. (2012). Early behavioral intervention is associated with normalized brain activity in young children with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 51(11), 1150–1159. https://doi.org/10.1016/j.jaac.2012.08.018
Delobel-Ayoub, M., Saemundsen, E., Gissler, M., Ego, A., Moilanen, I., Ebeling, H., et al. (2020). Prevalence of autism spectrum disorder in 7–9-year-old children in Denmark, Finland, France and Iceland: A population-based registries approach within the ASDEU project. Journal of Autism and Developmental Disorders, 50(3), 949–959. https://doi.org/10.1007/s10803-019-04328-y
Dereu, M., Warreyn, P., Raymaekers, R., Meirsschaut, M., Pattyn, G., Schietecatte, I., & Roeyers, H. (2010). Screening for autism spectrum disorders in Flemish day-care centres with the checklist for early signs of developmental disorders. Journal of Autism and Developmental Disorders, 40(10), 1247–1258. https://doi.org/10.1007/s10803-010-0984-0
Development Center for Primary Healthcare in Iceland. (2020). Leiðbeiningar um ung- og smábarnavernd [Guidelines on child healthcare]. http://www.throunarmidstod.is/svid-thih/ung-og-smabarnavernd/.
DuBay, M. (2020). Translation and cultural adaptation of autism screening tools [Doctoral dissertation]. University of North Carolina. https://doi.org/10.17615/fcwc-c425
Eaves, L. C., Wingert, H., & Ho, H. H. (2006). Screening for autism: Agreement with diagnosis. Autism, 10(3), 229–242. https://doi.org/10.1177/1362361306063288
Eusebi, P. (2013). Diagnostic accuracy measures. Cerebrovascular Diseases, 36(4), 267–272. https://doi.org/10.1159/000353863
Fernell, E., Eriksson, M. A., & Gillberg, C. (2013). Early diagnosis of autism and impact on prognosis: A narrative review. Clinical Epidemiology, 5, 33–43. https://doi.org/10.2147/clep.s41714
Fuller, E. A., & Kaiser, A. P. (2019). The effects of early intervention on social communication outcomes for children with autism spectrum disorder: A meta-analysis. Journal of Autism and Developmental Disorders, 50, 1683–1700. https://doi.org/10.1007/s10803-019-03927-z
Garcia-Primo, P., Hellendoorn, A., Charman, T., Roeyers, H., Dereu, M., Roge, B., et al. (2014). Screening for autism spectrum disorders: State of the art in Europe. European Child and Adolescent Psychiatry, 23(11), 1005–1021. https://doi.org/10.1007/s00787-014-0555-6
Glascoe, F. P. (2005). Screening for developmental and behavioral problems. Mental Retardation and Developmental Disabilities Research Review, 11(3), 173–179. https://doi.org/10.1002/mrdd.20068
Glascoe, F. P. (2009). PEDS Mat foreldra á þroska barna [Parents’ Evaluation of Developmental Status]. Námsmatsstofnun og Landlæknisembættið.
Goin-Kochel, R. P., Mire, S. S., & Dempsey, A. G. (2015). Emergence of autism spectrum disorder in children from simplex families: Relations to parental perceptions of etiology. Journal of Autism and Developmental Disorders, 45(5), 1451–1463. https://doi.org/10.1007/s10803-014-2310-8
Gudmundsson, E. (2008). WPPSI-RIS: Fræðilegur grundvöllur og túlkun [WPPSI-RIS: Theoretical foundation and interpretation]. Námsmatssofnun.
Gudmundsson, E., & Olafsdottir, H. (2003). Greindarpróf David Wechsler handa börnum á leikskóla- og grunnskólaaldri. Endurskoðuð útgáfa. Handbók. Íslensk staðfærsla og stöðlun [Weschler Preschool and Primary Scale of Intelligence, Revised. Manual for the Icelandic standardisation]. Námsmatsstofnun.
Gunnarsdottir, S. (2020). Snemmtæk íhlutun barna á leikskólaaldri meðan beðið er eftir greiningu á frávikum í taugaþroska [Early intervention of preschool aged children waiting for neurodevelopmental diagnostic assessment]. [Unpublished master´s thesis].University of Iceland.
Guo, C., Luo, M., Wang, X., Huang, S., Meng, Z., Shao, J., et al. (2019). Reliability and validity of the Chinese version of Modified Checklist for Autism in Toddlers, Revised, with Follow-up (M-CHAT-R/F). Journal of Autism and Developmental Disorders, 49(1), 185–196. https://doi.org/10.1007/s10803-018-3682-y
Guthrie, W., Wallis, K., Bennett, A., Brooks, E., Dudley, J., Gerdes, M., et al. (2019). Accuracy of autism screening in a large pediatric network. Pediatrics. https://doi.org/10.1542/peds.2018-3963
Hyman, S. L., Levy, S. E., & Myers, S. M. (2020). Identification, evaluation, and management of children with autism spectrum disorder. Pediatrics. https://doi.org/10.1542/peds.2019-3447
Interagency Autism Coordinating Committee. (2017). 2016–2017 Interagency Autism Coordinating Committee strategic plan for autism spectrum disorder. The U.S. Department of Health and Human Services Interagency Autism Coordinating Committee. https://iacc.hhs.gov/publications/strategic-plan/2017/.
Johnson, C., Myers, S., & the Council on Children with Disabilities. (2007). Identification and evaluation of children with autism spectrum disorders. Pediatrics, 120(5), 1183–1215
Johnson, M. H., & Munakata, Y. (2005). Processes of change in brain and cognitive development. Trends in Cognitive Sciences, 9(3), 152–158. https://doi.org/10.1016/j.tics.2005.01.009
Jonsdottir, S. L., Saemundsen, E., Gudmundsdottir, S., Haraldsdottir, G. S., Palsdottir, A. H., & Rafnsson, V. (2020). Implementing an early detection program for autism in primary healthcare: Screening, education of healthcare professionals, referrals for diagnostic evaluation, and early intervention. Research in Autism Spectrum Disorders. https://doi.org/10.1016/j.rasd.2020.101616
Jónsdóttir, S. L., Saemundsen, E., Antonsdóttir, I., Sigurdardóttir, S., & Ólason, D. (2011). Children diagnosed with autism spectrum disorder before or after the age of 6 years. Research in Autism Spectrum Disorders, 5(1), 175–184. https://doi.org/10.1016/j.rasd.2010.03.007
Jónsdóttir, S. L., Brynjarsdóttir, B., Saemundsen, E., & Sigurdsson, J. F. (2018). Long-term outcome of children with autism who received different forms of early intervention during their preschool years: A pilot study of 15 young adults. Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 6(1), 28–39. https://doi.org/10.21307/sjcapp-2018-006
Kamio, Y., Inada, N., Koyama, T., Inokuchi, E., Tsuchiya, K., & Kuroda, M. (2014). Effectiveness of using the Modified Checklist for Autism in Toddlers in two-stage screening of autism spectrum disorder at the 18-month health check-up in Japan. Journal of Autism and Developmental Disorders, 44(1), 194–203. https://doi.org/10.1007/s10803-013-1864-1
Khowaja, M., Robins, D. L., & Adamson, L. B. (2017). Utilizing two-tiered screening for early detection of autism spectrum disorder. Autism, 22(7), 881–890. https://doi.org/10.1177/1362361317712649
Kim, S. H., Bal, V. H., Benrey, N., Choi, Y. B., Guthrie, W., Colombi, C., et al. (2018). Variability in autism symptom trajectories using repeated observations from 14 to 36 months of age. Journal of the American Academy of Child and Adolescent Psychiatry, 57(11), 837-848.e2. https://doi.org/10.1016/j.jaac.2018.05.026
Kleinman, J. M., Robins, D. L., Ventola, P. E., Pandey, J., Boorstein, H. C., Esser, E. L., et al. (2008). The Modified Checklist for Autism in Toddlers: A follow-up study investigating the early detection of autism spectrum disorders. Journal of Autism and Developmental Disorders, 38(5), 827–839. https://doi.org/10.1007/s10803-007-0450-9
Lai, M.-C., & Baron-Cohen, S. (2015). Identifying the lost generation of adults with autism spectrum conditions. The Lancet Psychiatry, 2(11), 1013–1027. https://doi.org/10.1016/S2215-0366(15)00277-1
Landa, R. J. (2018). Efficacy of early interventions for infants and young children with, and at risk for, autism spectrum disorders. International Review of Psychiatry, 30(1), 25–39. https://doi.org/10.1080/09540261.2018.1432574
Landa, R. J., Gross, A. L., Stuart, E. A., & Faherty, A. (2013). Developmental trajectories in children with and without autism spectrum disorders: The first 3 years. Child Development, 84(2), 429–442. https://doi.org/10.1111/j.1467-8624.2012.01870.x
Levy, S. E., Wolfe, A., Coury, D., Duby, J., Farmer, J., Schor, E., et al. (2020). Screening tools for autism spectrum disorder in primary care: A systematic evidence review. Pediatrics, 145(Suppl 1), S47–S59. https://doi.org/10.1542/peds.2019-1895H
Li, C., Zhu, G., Feng, J., Xu, Q., Zhou, Z., Zhou, B., et al. (2018). Improving the early screening procedure for autism spectrum disorder in young children: Experience from a community-based model in Shanghai. Autism Research, 11(9), 1206–1217. https://doi.org/10.1002/aur.1984
Loomes, R., Hull, L., & Mandy, W. P. L. (2017). What is the male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 56(6), 466–474. https://doi.org/10.1016/j.jaac.2017.03.013
Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism Diagnostic Observation Schedule, Second Edition (ADOS-2). Manual (part I): Modules 1–4. Western Psychological Services.
Lyall, K., Croen, L., Daniels, J., Fallin, M. D., Ladd-Acosta, C., Lee, B. K., et al. (2017). The changing epidemiology of autism spectrum disorders. The Annual Review of Public Health, 38, 81–102. https://doi.org/10.1146/annurev-publhealth-031816-044318
Magán-Maganto, M., Bejarano-Martin, A., Fernandez-Alvarez, C., Narzisi, A., Garcia-Primo, P., Kawa, R., et al. (2017). Early detection and intervention of ASD: A European overview. Brain Science. https://doi.org/10.3390/brainsci7120159
Magán-Maganto, M., Canal-Bedia, R., Hernández-Fabián, A., Bejarano-Martín, Á., Fernández-Álvarez, C. J., Martínez-Velarte, M., et al. (2020). Spanish cultural validation of the Modified Checklist for Autism in Toddlers, Revised. Journal of Autism and Developmental Disorders, 50(7), 2412–2423. https://doi.org/10.1007/s10803-018-3777-5
Marks, K., Glascoe, F. P., Aylward, G. P., Shevell, M. I., Lipkin, P. H., & Squires, J. K. (2008). The thorny nature of predictive validity studies on screening tests for developmental-behavioral problems. Pediatrics, 122(4), 866–868. https://doi.org/10.1542/peds.2007-3142
Mazurek, M. O., Handen, B. L., Wodka, E. L., Nowinski, L., Butter, E., & Engelhardt, C. R. (2014). Age at first autism spectrum disorder diagnosis: The role of birth cohort, demographic factors, and clinical features. Journal of Developmental and Behavioral Pediatrics, 35(9), 561–569. https://doi.org/10.1097/dbp.0000000000000097
McPheeters, M. L., Weitlauf, A., Vehorn, A., Taylor, C., Sathe, N. A., Krishnaswami, S., et al., (2016). Screening for autism spectrum disorder in young children: A systematic evidence review for the U.S. Preventive Services Task Force. Evidence synthesis no. 129. AHRQ publication no. 13-05-185-EF-1. Agency for Healthcare Research and Quality.
Nygren, G., Cederlund, M., Sandberg, E., Gillstedt, F., Arvidsson, T., Carina Gillberg, I., et al. (2012). The prevalence of autism spectrum disorders in toddlers: A population study of 2-year-old Swedish children. Journal of Autism and Developmental Disorders, 42(7), 1491–1497. https://doi.org/10.1007/s10803-011-1391-x
Øien, R. A., Schjolberg, S., Volkmar, F. R., Shic, F., Cicchetti, D. V., Nordahl-Hansen, A., et al. (2018). Clinical features of children with autism who passed 18-month screening. Pediatrics, 141(6), e20173596. https://doi.org/10.1542/peds.2017-3596
Oner, O., & Munir, K. M. (2020). Modified Checklist for Autism in Toddlers Revised (M-CHATR/F) in an urban metropolitan sample of young children in Turkey. Journal of Autism and Developmental Disorders, 50(9), 3312–3319. https://doi.org/10.1007/s10803-019-04160-4
Oosterling, I. J., Wensing, M., Swinkels, S. H., van der Gaag, R. J., Visser, J. C., Woudenberg, T., et al. (2010). Advancing early detection of autism spectrum disorder by applying an integrated two-stage screening approach. Journal of Child Psychology and Psychiatry and Allied Disciplines, 51(3), 250–258. https://doi.org/10.1111/j.1469-7610.2009.02150.x
Ozonoff, S., Heung, K., Byrd, R., Hansen, R., & Hertz-Picciotto, I. (2008). The onset of autism: Patterns of symptom emergence in the first years of life. Autism Research, 1(6), 320–328. https://doi.org/10.1002/aur.53
Ozonoff, S., Iosif, A. M., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., et al. (2010). A prospective study of the emergence of early behavioral signs of autism. Journal of the American Academy of Child and Adolescent Psychiatry, 49(3), 256–266
Ozonoff, S., Young, G. S., Brian, J., Charman, T., Shephard, E., Solish, A., et al. (2018). Diagnosis of autism spectrum disorder after age 5 in children evaluated longitudinally since infancy. Journal of the American Academy of Child and Adolescent Psychiatry, 57(11), 849-857.e842. https://doi.org/10.1016/j.jaac.2018.06.022
Pearson, N., Charman, T., Happe, F., Bolton, P. F., & McEwen, F. S. (2018). Regression in autism spectrum disorder: Reconciling findings from retrospective and prospective research. Autism Research, 11(12), 1602–1620. https://doi.org/10.1002/aur.2035
Peters-Scheffer, N., Didden, R., Korzilius, H., & Matson, J. (2012). Cost comparison of early intensive behavioral intervention and treatment as usual for children with autism spectrum disorder in The Netherlands. Research in Developmental Disabilities, 33(6), 1763–1772. https://doi.org/10.1016/j.ridd.2012.04.006
Petrocchi, S., Levante, A., & Lecciso, F. (2020). Systematic review of level 1 and level 2 screening tools for autism spectrum disorders in toddlers. Brain Science. https://doi.org/10.3390/brainsci10030180
Piven, J., Elison, J. T., & Zylka, M. J. (2017). Toward a conceptual framework for early brain and behavior development in autism. Molecular Psychiatry, 22(10), 1385–1394. https://doi.org/10.1038/mp.2017.131
Roberts, M. Y., Stern, Y., Hampton, L. H., Grauzer, J. M., Miller, A., Levin, A., et al. (2019). Beyond pass-fail: Examining the potential utility of two thresholds in the autism screening process. Autism Research, 12(1), 112–122. https://doi.org/10.1002/aur.2045
Robins, D. L. (2020). How do we determine the utility of screening tools? Autism, 24(2), 271–273. https://doi.org/10.1177/1362361319894170
Robins, D. L., Casagrande, K., Barton, M., Chen, C. M., Dumont-Mathieu, T., & Fein, D. (2014). Validation of the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F). Pediatrics, 133(1), 37–45. https://doi.org/10.1542/peds.2013-1813
Robins, D. L., Fein, D., & Barton, M. (2009). The Modified Checklist for Autism in Toddlers Revised with Follow-up (M-CHAT-R/F). https://mchatscreen.com/.
Robins, D. L., Fein, D., Barton, M. L., & Green, J. A. (2001). The Modified Checklist for Autism in Toddlers: An initial study investigating the early detection of autism and pervasive developmental disorders. Journal of Autism and Developmental Disorders, 31(2), 131–144
Rutherford, M., McKenzie, K., Johnson, T., Catchpole, C., O’Hare, A., McClure, I., et al. (2016). Gender ratio in a clinical population sample, age of diagnosis and duration of assessment in children and adults with autism spectrum disorder. Autism, 20(5), 628–634. https://doi.org/10.1177/1362361315617879
Sangare, M., Toure, H. B., Toure, A., Karembe, A., Dolo, H., Coulibaly, Y. I., et al. (2019). Validation of two parent-reported autism spectrum disorders screening tools M-CHAT-R and SCQ in Bamako, Mali. eNeurologicalSci. https://doi.org/10.1016/j.ensci.2019.100188
Seung, H., Ji, J., Kim, S. J., Sung, I., Youn, Y. A., Hong, G., Lee, H., et al. (2015). Examination of the Korean Modified Checklist of Autism in Toddlers: Item response theory. Journal of Autism and Developmental Disorders, 45(9), 2744–2757. https://doi.org/10.1007/s10803-015-2439-0
Siu, A. L., Bibbins-Domingo, K., Grossman, D. C., Baumann, L. C., Davidson, K. W., Ebell, M., et al. (2016). Screening for autism spectrum disorder in young children: US Preventive Services Task Force recommendation statement. JAMA, 315(7), 691–696. https://doi.org/10.1001/jama.2016.0018
Soto, S., Linas, K., Jacobstein, D., Biel, M., Migdal, T., & Anthony, B. J. (2015). A review of cultural adaptations of screening tools for autism spectrum disorders. Autism, 19(6), 646–661. https://doi.org/10.1177/1362361314541012
Stenberg, N., Bresnahan, M., Gunnes, N., Hirtz, D., Hornig, M., Lie, K. K., et al. (2014). Identifying children with autism spectrum disorder at 18 months in a general population sample. Paediatric and Perinatal Epidemiology, 28(3), 255–262. https://doi.org/10.1111/ppe.12114
Stenberg, N., Schjølberg, S., Shic, F., Volkmar, F., Øyen, A. S., Bresnahan, M., et al. (2020). Functional outcomes of children identified early in the developmental period as at risk for ASD utilizing the the Norwegian mother, father and child cohort study (MoBa). Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-020-04539-8
Wechsler, D. (1989). Manual for Weschler Preschool and Primary Scale of Intelligence, Revised. The Psychological Corporation.
Wiggins, L. D., Baio, J., & Rice, C. (2006). Examination of the time between first evaluation and first autism spectrum diagnosis in a population-based sample. Journal of Developmental and Behavioral Pediatrics, 27(2), 79–87
Windiani, I., Soetjiningsih, S., Adnyana, I., & Lestari, K. (2016). Indonesian Modified Checklist for Autism in Toddler, Revised with Follow-up (M-CHAT-R/F) for autism screening in children at Sanglah General Hospital, Bali-Indonesia. Bali Medical Journal, 5(2), 311–315. https://doi.org/10.15562/bmj.v5i2.240
World Health Organization. (1993). The ICD-10 classification of mental and behavioural disorders. Diagnostic criteria for research. World Health Organization.
Yirmiya, N., & Charman, T. (2010). The prodrome of autism: Early behavioral and biological signs, regression, peri- and post-natal development and genetics. Journal of Child Psychology and Psychiatry and Allied Disciplines, 51(4), 432–458. https://doi.org/10.1111/j.1469-7610.2010.02214.x
Yuen, T., Penner, M., Carter, M. T., Szatmari, P., & Ungar, W. J. (2018). Assessing the accuracy of the Modified Checklist for Autism in Toddlers: A systematic review and meta-analysis. Developmental Medicine and Child Neurology, 60(11), 1093–1100. https://doi.org/10.1111/dmcn.13964
Zwaigenbaum, L., Bryson, S., & Garon, N. (2013). Early identification of autism spectrum disorders. Behavioural Brain Research, 251, 133–146. https://doi.org/10.1016/j.bbr.2013.04.004
Acknowledgements
The authors would like to thank all the participating families and the clinicians at the participating centers for their collaboration and the directorates at the PHC and the SDCC for their support. We also want to thank Gyda S. Haraldsdottir for reviewing the files of the Center for Development and Behavior to identify cases.
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SLJ received a Grant from the Public Health Fund in Iceland (P-2019-10-14-0010).
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SLJ contributed to the conception and design of the study; coordinated the project; collected, analyzed, and interpreted the data; and wrote the first draft of the manuscript. ES and VR contributed to the conception and design of the study, interpreted the data, and helped draft the manuscript. BG provided a statistical consultation and participated in the data analysis and interpretation. All authors read and revised earlier drafts of the manuscript and approved the final version.
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Jonsdottir, S.L., Saemundsen, E., Jonsson, B.G. et al. Validation of the Modified Checklist for Autism in Toddlers, Revised with Follow-up in a Population Sample of 30-Month-Old Children in Iceland: A Prospective Approach. J Autism Dev Disord 52, 1507–1522 (2022). https://doi.org/10.1007/s10803-021-05053-1
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DOI: https://doi.org/10.1007/s10803-021-05053-1