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Preoperative ocular coherence tomographic prognosticators of visual acuity after idiopathic epiretinal membrane surgery

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Abstract

Purpose

To provide a current review of the evidence for the utility of preoperative ocular coherence tomography (OCT) parameters in prognosticating postoperative visual acuity and visual improvement after idiopathic epiretinal membrane surgery. To determine which OCT bio-markers are most useful in this regard and where future studies may apply more emphasis.

Methods

An extensive search of the PubMed database was performed for studies investigating this relationship. Key search terms included: idiopathic, epiretinal membrane, surgery, peel, vitrectomy, vision, outcomes, visual acuity, ocular coherence tomography, central foveal thickness, foveal contour, foveal morphology, ectopic inner foveal layers, inner retinal layers, inner retinal irregularity index, outer retinal layers, ellipsoid zone, interdigitation zone, photoreceptor outer segment length, central bouquet abnormality, staging, choroidoscleral irregularity, ganglion cell and nerve fibre layers, inner and outer plexiform layers, inner and outer nuclear layers. Forty-nine peer-reviewed articles were included in this review. These consisted of 28 retrospective studies [1,2,3,13,16,17,18,20,23,24,25,26,27,28,29,32,33,34,35,36,38,40,42,43,44,45,46,47], 17 prospective studies[6,7,8,9,10,11,12,14,19,21,22,30,31,37,41,48,49], 2 reviews [4,39] and 2 systematic reviews [5,15].

Conclusion

The weight of literary evidence seems to support photoreceptor integrity as the most consistent OCT marker of better postoperative visual acuity. This includes analysis of ellipsoid and interdigitation zones as well as photoreceptor outer segment length. However, the newer OCT staging system proposed by Govetto et al. (2017) fulfils a need for a clinically useful and evidence-based OCT classification. It may be the way forward in prognosticating ERM surgical outcomes by preoperative stratification. There is insufficient evidence to suggest the other discussed parameters in this review as useful prognosticators of postoperative visual acuity.

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All studies referenced in this paper were accessed online via the PubMed database.

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References

  1. Itoh Y, Inoue M, Rii T, Hirota K, Hirakata A (2013) Correlation between foveal cone outer segment tips line and visual recovery after epiretinal membrane surgery. Invest Ophthalmol Vis Sci 54:7302–7308

    Article  PubMed  Google Scholar 

  2. Kim JH, Kim YM, Chung EJ, Lee SY, Joh HJ (2012) Structural and functional predictors of visual outcome of epiretinal membrane surgery. Am J Ophthalmol 153(103–110):e1

    Google Scholar 

  3. Michalewski J, Michalewska Z, Cisiecki S, Nawrocki J (2007) Morphologically functional correlations of macular pathology connected with epiretinal membrane formation in spectral optical coherence tomography (SOCT). Graefes Arch Clin Exp Ophthalmol 245:1623–1631

    Article  PubMed  Google Scholar 

  4. Fung AT, Glavin J, Tran T (2021) Epiretinal membrane: a review. Clin Exp Ophthalmol 49:289–308

    Article  PubMed  Google Scholar 

  5. Scheerlinck LME, van der Valk R, van Leeuwen R (2015) Predictive factors for postoperative visual acuity in idiopathic epiretinal membrane: a systematic review. Acta Ophthalmol 93:203–212

    Article  PubMed  Google Scholar 

  6. Parisi V, Coppe AM, Gallinaro G, Stirpe M (2007) Assessment of macular function by focal electroretinogram and pattern electroretinogram before and after epimacular membrane surgery. Retina 27(3):312–320

    Article  PubMed  Google Scholar 

  7. Niwa T, Terasaki H, Kondo M, Piao C-H, Suzuki T, Miyake Y (2003) Function and morphology of macula before and after removal of idiopathic epiretinal membrane. Invest Ophthalmol Vis Sci 44:1652–1656

    Article  PubMed  Google Scholar 

  8. Shimada Y, Sakurai S, Naito K, Sugino T, Kojima Y, Hori K, Horiguchi M (2011) Multifocal electroretinogram and optical coherent tomography: prediction of visual outcome after epiretinal membrane removal. Clin Exp Optom 94(3):296–301

    Article  PubMed  Google Scholar 

  9. Michalewska Z, Michaleski J, Adelman RA, Zawislak E, Nawrocki J (2015) Choroidal thickness measured with swept source optical coherence tomography before and after vitrectomy with internal limiting membrane peeling for idiopathic epiretinal membranes. Retina 35:487–491

    Article  PubMed  Google Scholar 

  10. Mitamura T, Hirano K, Baba T, Yamamoto S (2009) Correlation of visual recovery with presence of photoreceptor inner/outer segment junction in optical coherence images after epiretinal membrane surgery. Br J Ophthalmol 93:171–175

    Article  CAS  PubMed  Google Scholar 

  11. Shiono A, Kogo J, Klose G, Takeda H, Ueno H, Tokuda N, Inoue J, Matsuzawa A, Kayama N, Ueno S, Takagi H (2013) Photoreceptor outer segment length: a prognostic factor for idiopathic epiretinal membrane surgery. Ophthalmology 120:788–794

    Article  PubMed  Google Scholar 

  12. Suh MH, Seo JM, Park KH, Yu HG (2009) Associations between macular findings by optical coherence tomography and visual outcomes after epiretinal membrane removal. Am J Ophthalmolol 147(473–480):e3

    Google Scholar 

  13. Kunikata H, Abe T, Kinukawa J, Nishida K (2011) Preoperative factors predictive of postoperative decimal visual acuity >/= 1.0 following surgical treatment for idiopathic epiretinal membrane. Clin Ophthalmol 5:147–154

    Article  PubMed  PubMed Central  Google Scholar 

  14. Kim JH, Kang SW, Kong MG, Ha HS (2013) Assessment of retinal layers and visual rehabilitation after epiretinal membrane removal. Graefes Arch Clin Exp Ophthalmol 251:1055–1064

    Article  PubMed  Google Scholar 

  15. Miguel AI, Legris A (2017) Prognostic factors of epiretinal membranes: a systematic review. J Fr Ophthalmol 40(1):61–79

    Article  CAS  Google Scholar 

  16. Kim M, Lee Y, Kim R-Y, Kwak JH, Park Y-H (2020) Choroidoscleral interface irregularity index: a novel optical coherence tomography-based parameter in patients with epiretinal membrane. Sci Rep 10:696. https://doi.org/10.1038/s41598-020-57656-w

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Shimozono M, Oishi A, Hata M, Matsuki T, Ito S, Ishida K, Jurimoto Y (2012) The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery. Am J Ophthalmol 153(698–704):e1

    Google Scholar 

  18. Ortoli M, Blanco-Garavito R, Blautain B, Mastorakos N, Souied EH, Glacet-Bernard A (2021) Prognostic factors of idiopathic epiretinal membrane surgery and evolution of alterations of the central cone bouquet. Graefes Arch Clin Exp Ophthalmol, epub,. https://doi.org/10.1007/s00417-021-05110-6

    Article  Google Scholar 

  19. Michalewska Z, Michaleski J, Ornafel-Sagan K, Nawrocki J (2016) Swept-source optical coherence tomography correlations between retina and choroid before and after vitrectomy for epiretinal membranes. Am J Ophthalmol 165:100–107

    Article  PubMed  Google Scholar 

  20. Park YG, Hong SY, Roh Y-J (2020) Novel optical coherence tomography parameters as prognostic factors for stage 3 epiretinal membranes. J Ophthalmol, e-collection,. https://doi.org/10.1155/2020/9861086

    Article  Google Scholar 

  21. Garcia-Fernandez M, Navarro JC, Castano CG, Alonso AG, Gil MF (2013) Epiretinal membrane surgery: anatomic and functional outcomes. Arch Soc Esp Oftalmol 88:139–144

    CAS  PubMed  Google Scholar 

  22. Inoue M, Morita S, Watanabe Y, Kaneko T, Yamane S, Kobayashi S, Arakawa A, Kadonosono K (2011) Preoperative inner segment/outer segment junction in spectral-domain optical coherence tomography as a prognostic factor in epiretinal membrane surgery. Retina 31:1366–1372

    Article  PubMed  Google Scholar 

  23. Fernandes TF, Sousa K, Azevedo I, Gouveia P, Calvao-Santos G, Gomes N, Falcao M (2021) Baseline visual acuity and interdigitation zone as predictors in idiopathic epiretinal membranes: a retrospective cohort study. Eur J Ophthalmol 31(3):1291–1298

    Article  PubMed  Google Scholar 

  24. Coppola M, Brambati M, Cicinelli MV, Marchese A, Zanzottera EC, Deiro AP, Post M, Bandello F (2021) The visual outcomes of idiopathic epiretinal membrane removal in eyes with ectopic inner foveal layers and preserved macular segmentation. Grafes Arch Clin Exp Ophthalmol 259:2193–2201

    Article  CAS  Google Scholar 

  25. Jeon S, Jung B, Lee WK (2019) Long-term prognostic factors for visual improvement after epiretinal membrane removal. Retina 39:1786–1793

    Article  PubMed  Google Scholar 

  26. Ozdek S, Zeydanli EO, Karabas L, Teke MY, Yilmaz G, Citirik M, Kocak N, Durukan H (2021) Relation of anatomy with function following the surgical treatment of idiopathic epiretinal membrane: a multicenter retrospective study. Graefes Arch Clin Exp Ophthalmol 259:891–904

    Article  CAS  PubMed  Google Scholar 

  27. Joe SG, Lee KS, Lee JY, Hwang J-U, Kim J-G, Yoon YH (2013) Inner retinal layer thickness is the major determinant of visual acuity in patients with idiopathic epiretinal membrane. Acta Ophthalmol 91(3):e242–e243

    Article  PubMed  Google Scholar 

  28. Zeyer JC, Parker P, Dajani O, Maccumber MW (2021) Preoperative domed macular contour correlates with postoperative visual gain after vitrectomy for symptomatic epiretinal membrane. Retina 41:505–509

    Article  CAS  PubMed  Google Scholar 

  29. Kromer R, Vogt C, Wagenfeld L, Spitzer MS, Stemplewitz B (2018) Predicting surgical success in patients with idiopathic epiretinal membrane using the spectral-domain optical coherence tomography segmentation module for single retinal layer analysis. Current Eye Res 43(8):1024–1031

    Article  Google Scholar 

  30. Falkner-Radler CI, Glittenberg C, Hagen S, Benesch T, Binder S (2010) Spectral domain optical coherence tomography for monitoring epiretinal membrane surgery. Ophthalmology 117:798–805

    Article  PubMed  Google Scholar 

  31. Brito PN, Gomes NL, Vieira MP, Faria PA, Fernandes AV, Rocha-Sousa A, Falcao-Reis F (2014) Possible role for fundus autofluorescence as a predictive factor for visual acuity recovery after epiretinal membrane surgery. Retina 34:273–280

    Article  PubMed  Google Scholar 

  32. Kinoshita T, Kovacs K, Wagley S, Arroyo JG (2011) Morphologic differences in epiretinal membranes on ocular coherence tomography as a predictive factor for surgical outcome. Retina 31:1692–1698

    Article  PubMed  Google Scholar 

  33. Govetto A, Lelane RA III, Sarraf D, Figueroa MS, Hubschman JP (2017) Insights into epiretinal membranes: presence of ectopic inner foveal layers and a new optical coherence tomography staging scheme. Ophthalmol 175:99–113

    Google Scholar 

  34. Govetto A, Virgili G, Rodriguez FJ, Figueroa MS, Sarraf D, Hubschman JP (2019) Functional and anatomical significance of the ectopic inner foveal layers in eyes with idiopathic epiretinal membranes. Retina 39:347–357

    Article  PubMed  Google Scholar 

  35. Gonzalez-Saldivar G, Berger A, Wong D, Juncal V, Chow DR (2020) Ectopic inner foveal layer classification scheme predicts visual outcomes after epiretinal membrane surgery. Retina 40:710–717

    Article  PubMed  Google Scholar 

  36. Zur D, Iglicki M, Feldinger L, Schwartz S, Goldstein M, Loewenstein A, Barak A (2018) Disorganization of retinal inner layers as a biomarker for idiopathic epiretinal membrane after macular surgery - the dream study. Am J Ophthalmol 196:129–135

    Article  PubMed  Google Scholar 

  37. Zou J, Tan W, Huang W, Liu K, Li F, Xu H (2020) Association between individual retinal layer thickness and visual acuity in patients with epiretinal membrane: a pilot study. PeerJ 8:e9481. https://doi.org/10.7717/peerj.9481

    Article  PubMed  PubMed Central  Google Scholar 

  38. Cho KH, Park SJ, Cho JH, Woo SJ, Park KH (2016) Inner-retinal irregularity index predicts postoperative visual prognosis in idiopathic epiretinal membrane. Am J Ophthalmol 168:139–149

    Article  PubMed  Google Scholar 

  39. Tao LW, Wu Z, Guymer RH, Luu CD (2016) Ellipsoid zone on optical coherence tomography: a review. Clin Exp Ophthalmol 44:422–430

    Article  PubMed  Google Scholar 

  40. Cobos E, Arias L, Ruiz-Moreno J, Rubio M, Garcia-Bru P, Caminal J, Catala-Mora J, Arruga J (2013) Preoperative study of the inner segment/outer segment junction of photoreceptors by spectral-domain optical coherence tomography as a prognostic factor in patients with epiretinal membranes. Clin Ophthalmol 7:1467–1470

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Kinoshita T, Imaizumi H, Miyamoto H, Katome T, Semba K, Mitamura Y (2016) Two-year results of metamorphopsia, visual acuity, and optical coherence tomographic parameters after epiretinal membrane surgery. Graefes Arch Clin Exp Ophthalmol 254(6):1041–1049

    Article  PubMed  Google Scholar 

  42. Kim HJ, Kang J-W, Chung H, Kim HC (2014) Correlation of foveal photoreceptor integrity with visual outcome in idiopathic epiretinal membranes. Curr Eye Res 39(6):626–633

    Article  PubMed  Google Scholar 

  43. Hashimoto Y, Saito W, Saito M, Hirooka K, Fujiya A, Yoshizawa C, Noda K, Ishida S (2014) Retinal outer layer thickness increases after vitrectomy for epiretinal membrane, and visual improvement positively correlates with photoreceptor outer segment length. Grafes Arch Clin Exp Ophthalmol 252:219–226

    Article  Google Scholar 

  44. Govetto A, Bhavsar KV, Virgili G, Gerber MJ, Freund KB, Curcio CA, Burgoyne CF, Hubschman J-P, Sarraf D (2017) Tractional abnormalities of the central foveal bouquet in epiretinal membranes: clinical spectrum and pathophysiological perspectives. Am J Ophthalmol 184:167–180

    Article  PubMed  Google Scholar 

  45. Tsunoda K, Watanabe K, Akiyama K, Usui T, Noda T (2012) Highly reflective foveal region in optical coherence tomography in eyes with vitreomacular traction or epiretinal membrane. Ophthalmol 119(3):581–587

    Article  Google Scholar 

  46. Brinkmann MP, Michels S, Brinkmann C, Toro MD, Johansen NG, Rommel F, Ranjbar M, Becker M (2021) Influences of central bouquet alterations on the visual outcome in eyes receiving epiretinal membrane surgery. Appl Sci 11(3):926

    Article  CAS  Google Scholar 

  47. Uji A, Murakami T, Unoki N, Ogino K, Nishijima K, Yoshitake S, Dodo Y, Yoshimura N (2014) Parallelism as a novel marker for structural integrity of retinal layers in optical coherence tomographic images in eyes with epiretinal membrane. Am J Ophthalmol 157:227–236

    Article  PubMed  Google Scholar 

  48. Doguizi S, Sekeroglu MA, Ozkoyuncu D, Omay AE, Yilmazbas P (2018) Clinical significance of ectopic inner foveal layers in patients with idiopathic epiretinal membranes. Eye 32:1652–1660

    Article  PubMed  PubMed Central  Google Scholar 

  49. Hirata A, Nakada H, Mine K, Masumoto M, Sato T, Hayashi K (2019) Relationship between the morphology of the foveal avascular zone and the degree of aniseikonia before and after vitrectomy in patients with unilateral epiretinal membrane. Graefes Arch Clin Exp Ophthalmol 257:507–515

    Article  PubMed  Google Scholar 

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  1. Ophthalmology Department, Royal Brisbane and Women’s Hospital, Level 8 Ned Hanlon Building, Brisbane, QLD, 4029, Australia

    Rajan Singh Patheja

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Patheja, R.S. Preoperative ocular coherence tomographic prognosticators of visual acuity after idiopathic epiretinal membrane surgery. Int Ophthalmol 42, 3243–3252 (2022). https://doi.org/10.1007/s10792-022-02317-2

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