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Intercalary membrane break and detachment causes intrachoroidal cavitation in macular coloboma

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Abstract

Purpose

To describe the clinical and imaging features in a series of patients diagnosed with macular coloboma (MC) and intrachoroidal cavitation (ICC).

Methods

Patients diagnosed with MC based on clinical examination between June 2017 and July 2021 were retrieved from the electronic medical record system and were included in the study. Colour fundus photographs, optical coherence tomography (OCT) and Multicolour® imaging scans of these patients were analysed.

Results

We identified 16 eyes of 11 patients with MC on fundus examination. Based on OCT imaging features, conforming variant of MC was seen in 9 (56%) eyes and non-conforming variant in 7 (44%) eyes. No eyes with MC in the study showed features of both conforming and non-conforming varieties simultaneously. In the non-conforming variety of MC with presence of intercalary membrane break, ICC was identified in 5 (71%) of these eyes. ICC in MC appeared as flat, dark greenish areas with or without an orange-coloured boundary abutting the margin of the coloboma on Multicolour® imaging.

Conclusion

In 31% eyes, ICC was seen in non-conforming type of MC and was well-identified on Multicolour® imaging. It appears that presence of intercalary membrane break and detachment are prerequisites for developing ICC.

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Data availability

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We would like to thank our technicians, Mr Abhishek, Mr Deekshit, Mr Manjunath and Mr Madhu for their contribution in acquiring the images and providing them to us for analysis in this study.

Funding

No funding has been obtained for this research work.

Author information

Authors and Affiliations

  1. Department of Retina and Vitreous, Narayana Nethralaya, #121/C, Chord Road, 1st R Block Rajaji Nagar, Bangalore, 560010, India

    Ramesh Venkatesh, Rohit Agrawal, Nikitha Gurram Reddy, Aditi Gupta & Naresh Kumar Yadav

  2. Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, 203 Lothrop Street, Suite 800, Pittsburgh, PA, 15213, USA

    Jay Chhablani

Authors
  1. Ramesh Venkatesh
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  2. Rohit Agrawal
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  3. Nikitha Gurram Reddy
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  4. Aditi Gupta
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  5. Naresh Kumar Yadav
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  6. Jay Chhablani
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Contributions

RV and JC contributed to conceptualising the study, data acquisition, analysing the data, statistics and results, interpreting the findings, and writing and reviewing the manuscript. AG, ROH, and NR involved in data acquisition and analysing the data. NKY involved in reviewing the manuscript.

Corresponding author

Correspondence to Ramesh Venkatesh.

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Conflict of interest

The authors declare that they have no conflict of interests.

Ethics approval and consent to participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Narayana Nethralaya institutional review board – (C-2021-07-003) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards”.

Consent for publication

Informed consent was obtained from all individual participants included in the study. The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given his consent for his/her images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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This article does not contain any studies with animals performed by any of the authors.

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Venkatesh, R., Agrawal, R., Reddy, N.G. et al. Intercalary membrane break and detachment causes intrachoroidal cavitation in macular coloboma. Int Ophthalmol 42, 2581–2589 (2022). https://doi.org/10.1007/s10792-022-02306-5

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  • DOI: https://doi.org/10.1007/s10792-022-02306-5

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