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Liver Cirrhosis Increases the Risk of Developing Advanced Colon Polyps

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Abstract

Goals

To analyze our experience with adenoma detection rates in patients with liver cirrhosis in a community setting.

Background

Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer death in men and women in the USA. The majority of CRCs arise from premalignant polyps (adenomas), which are typically detected and removed during colonoscopy. Data are limited on the risk of CRC in patients with various chronic liver diseases and the association between CRC and demographics, liver disease etiology and colonoscopy findings.

Study Results

A total of 351 colonoscopies were performed (2006 to 2019) in patients with liver cirrhosis. Mean age was 62.3 ± 9.4 years, there were 158 females and 193 males. Adenomas were found in 159 procedures (49.07%) and were more likely found in the right colon (76.73%) vs the left colon (18.87%). Left-sided adenoma occurrence was significantly lower in women (61% lower than men, p = 0.05). Neither indication for the procedure (p = 0.08) nor advancing age (p = 0.94) affected adenoma detection rates. No significant differences were observed in the findings of adenomas between different chronic liver diseases.

Conclusions

Adenoma detection rates in patients with cirrhosis (49%) undergoing elective colonoscopy were higher than rates reported in the literature for LT candidates (22–42%) undergoing standardized screenings. Colonoscopy screenings should be expanded to all patients with cirrhosis, regardless of etiology.

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Authors and Affiliations

  1. South Denver Gastroenterology, Englewood, CO, 80113, USA

    Maxine Kugelmas & Marcelo Kugelmas

  2. Department of Biomedical Sciences, Rocky Vista University, Parker, CO, 80134, USA

    Isain Zapata

  3. Gastroenterologia Diagnostica y Terapéutica – Belgrano, Buenos Aires, Argentina

    Jose Tawil

  4. Department of Internal Medicine, Dell Seton Medical Center at the University of Texas, Austin, TX, 78701, USA

    Annelisa Pessetto

  5. Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA

    Michael Taglienti

Authors
  1. Maxine Kugelmas
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  2. Isain Zapata
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  6. Marcelo Kugelmas
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Correspondence to Marcelo Kugelmas.

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Kugelmas, M., Zapata, I., Tawil, J. et al. Liver Cirrhosis Increases the Risk of Developing Advanced Colon Polyps. Dig Dis Sci 68, 931–938 (2023). https://doi.org/10.1007/s10620-022-07561-1

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  • DOI: https://doi.org/10.1007/s10620-022-07561-1

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