New derivatives of 3-methylcytisine with 9-aromatic substituents bonded to the pyridone core of the starting alkaloid through spacers of various natures, e.g., aminomethyl, amide, thio- and carboxamide, ethenyl, and ethyl, were synthesized from 9-amino- and 9-bromo-2-oxomethylcytisine.
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Acknowledgment
The work was performed in the framework of a State Task for UfIC, UFRC, RAS, on topic “Synthesis of biologically active compounds based on natural compounds. Creation of ecologically clean materials and technologies,” No. 122031400260-7 (ANL, VAS, VAD) and was supported by the Russian Science Foundation, Project No. 22-43-08002 “Development of new inhibitors of pathogenic flaviviruses based on plant triterpenoids and alkaloids” (NPTs, AVK).
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Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2023, pp. 616–620.
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Koval′skaya, A.V., Lobov, A.N., Sorokina, V.A. et al. Synthesis of New 9-Substituted Derivatives of 2-Oxomethylcytisine. Chem Nat Compd 59, 738–742 (2023). https://doi.org/10.1007/s10600-023-04099-0
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DOI: https://doi.org/10.1007/s10600-023-04099-0