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A simple route for the synthesis of substituted thiazole derivatives by multicomponent reaction between arylglyoxals, acetylacetone or ethyl acetoacetate, and thiosemicarbazones

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Chemistry of Heterocyclic Compounds Aims and scope

An effective one-pot three-component protocol for the synthesis of polysubstituted thiazole derivatives is reported. The reaction proceeds between arylglyoxals, thiosemicarbazones, and acetylacetone or ethyl acetoacetate in ethanol as solvent and in the presence of acetic acid as catalyst.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, 22 Bahman Sq., Rafsanjan, 77176, Iran

    Mahsa Latifi, Mohammad Anary-Abbasinejad & Marziyeh Mohammadi

Authors
  1. Mahsa Latifi
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  2. Mohammad Anary-Abbasinejad
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  3. Marziyeh Mohammadi
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Correspondence to Mohammad Anary-Abbasinejad.

Additional information

Published in Khimiya Geterotsiklicheskikh Soedinenii, 2023, 59(9/10), 709–712

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Latifi, M., Anary-Abbasinejad, M. & Mohammadi, M. A simple route for the synthesis of substituted thiazole derivatives by multicomponent reaction between arylglyoxals, acetylacetone or ethyl acetoacetate, and thiosemicarbazones. Chem Heterocycl Comp 59, 709–712 (2023). https://doi.org/10.1007/s10593-023-03258-z

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  • DOI: https://doi.org/10.1007/s10593-023-03258-z

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