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Synthesis of new 4-amino-substituted 7-iminopyrido[2,3-d]pyrimidines

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Chemistry of Heterocyclic Compounds Aims and scope

The reaction of 4,6-dichloropyrimidine-5-carbaldehyde with cyanomethyltriphenylphosphonium chloride gave (2Е)-3-(4,6-dichloropyrimidin-5-yl)acrylonitrile, which was further used for the preparation of 4,6-diamino-substituted pyrimidinylacrylonitrile derivatives, capable of intramolecular cyclization with the formation of new 4-amino-substituted 7-iminopyrido[2,3-d]pyrimidines. Performing the reaction with 4-amino-6-chloropyrimidine-5-carbaldehyde led to 7-amino-4-chloropyrido[2,3-d]pyrimidine, a promising intermediate for the synthesis of pyrido[2,3-d]pyrimidine-4,7-diamines.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine

    Anna N. Zinchenko, Lyubov V. Muzychka, Igor I. Biletskii & Oleg B. Smolii

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  1. Anna N. Zinchenko
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  2. Lyubov V. Muzychka
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  3. Igor I. Biletskii
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  4. Oleg B. Smolii
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Correspondence to Oleg B. Smolii.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2017, 53(5), 589–596

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Zinchenko, A.N., Muzychka, L.V., Biletskii, I.I. et al. Synthesis of new 4-amino-substituted 7-iminopyrido[2,3-d]pyrimidines. Chem Heterocycl Comp 53, 589–596 (2017). https://doi.org/10.1007/s10593-017-2096-7

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  • DOI: https://doi.org/10.1007/s10593-017-2096-7

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