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Amination of 2-chloro-and 2,4-dichloropyrimidines by polyamines

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Chemistry of Heterocyclic Compounds Aims and scope

A study was carried out on the amination of 2-chloro-and 2,4-dichloropyrimidines by linear polyamines and oxadiamines under catalytic and noncatalytic conditions. The reaction of excess polyamine with 2-chloropyrimidine gives the corresponding 2-aminopyrimidines, while the reaction of polyamines with excess of 2-chloropyrimidine gives di-, tri-, and tetraarylated derivatives. The reaction of 2,4-dichloropyrimidine with diamines was studied with different ratios of the starting reagents. The ratios of the products of substitution at pyrimidine C-2 and C-4 were found.

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Authors and Affiliations

  1. M. V. Lomonosov Moscow State University, Moscow, 119992, Russia

    A. D. Averin, O. A. Ulanovskaya & I. P. Beletskaya

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  1. A. D. Averin
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  2. O. A. Ulanovskaya
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  3. I. P. Beletskaya
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Correspondence to A. D. Averin.

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Dedicated to Academician B. A. Trofimov on the occasion of his seventieth jubilee.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1418–1431, September, 2008.

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Averin, A.D., Ulanovskaya, O.A. & Beletskaya, I.P. Amination of 2-chloro-and 2,4-dichloropyrimidines by polyamines. Chem Heterocycl Comp 44, 1146–1157 (2008). https://doi.org/10.1007/s10593-008-0165-7

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  • DOI: https://doi.org/10.1007/s10593-008-0165-7

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