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Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/β-Catenin and PI3K/AKT Signaling Pathways

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Abstract

Gliomas are a deadly primary malignant tumor of the central nervous system, with glioblastoma (GBM) representing the most aggressive type. The clinical prognosis of GBM patients remains bleak despite the availability of multiple options for therapy, which has needed us to explore new therapeutic methods to face the rapid progression, short survival, and therapy resistance of glioblastomas. As the Human Genome Project advances, long noncoding RNAs (lncRNAs) have attracted the attention of researchers and clinicians in cancer research. Numerous studies have found aberrant expression of signaling pathways in glioma cells. For example, lncRNAs not only play an integral role in the drug resistance process by regulating the Wnt/β-catenin or PI3K/Akt signaling but are also involved in a variety of malignant biological behaviors such as glioma proliferation, migration, invasion, and tumor apoptosis. Therefore, the present review systematically assesses the existing research evidence on the malignant progression and drug resistance of glioma, focusing on the critical role and potential function of lncRNAs in the Wnt/β-catenin and PI3K/Akt classical pathways to promote and encourage further research in this field.

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Funding

Natural Science Foundation of Shandong Province, Grant/Award Number: ZR2022MH140; Project funded by China Postdoctoral Science Foundation, Grant/Award Number: 2022M711324. 

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Authors and Affiliations

  1. Cheeloo College of Medicine, Shandong University, Jinan, 250012, China

    Hanyun Li & Yan Liu

  2. Department of Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, 272029, Shandong, China

    Jilan Liu & Xianyun Qin

  3. Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Neurosurgery, Jinan, 250014, China

    Jikui Sun

  4. School of Mental Health, Jining Medical University, Jining, 272013, China

    Yan Liu

  5. The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, 266042, China

    Feng Jin

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Contributions

All authors contributed to the study conception and design. JS had the idea for the article. YL, JL, XQ and HL performed the literature search. JS, YL, and FJ revised the work. The first draft of the manuscript was written by HL and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Jikui Sun, Yan Liu or Feng Jin.

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Li, H., Liu, J., Qin, X. et al. Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/β-Catenin and PI3K/AKT Signaling Pathways. Cell Mol Neurobiol 43, 3929–3942 (2023). https://doi.org/10.1007/s10571-023-01414-9

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