Abstract
This study aimed to evaluate the potential prognostic value of ferroptosis-related long non-coding RNAs (lncRNAs) in papillary thyroid carcinoma (PTC). Based on The TCGA database, lncRNAs and ferroptosis-related genes with differential expression levels in PTC tumors vs. normal tissues were screened. After the co-expression network construction, ferroptosis-related lncRNAs (FRLs) were screened. Kaplan–Meier analysis was conducted to compare the survival performance of patients with PTC in the high- and low-risk groups. Furthermore, a nomogram was created to enhance PTC prognosis. CIBERSORT was used to investigate the infiltration of various immune cells in high- and low-risk groups. In total, 10 lncRNA pairs with differential expression levels were obtained. There were significant differences in the histological subtype and pathological stage between the high- and low-risk groups, and age (P = 7.39E-13) and FRLM model status (P = 1.09E-04) were identified as independent prognostic factors. Subsequently, the nomogram survival model showed that the predicted one-, three-, and five-year survival rates were similar to the actual one- (c-index = 0.8475), three- (c-index = 0.7964), and five-year (c-index = 0.7555) survival rates. Subjects in the low-risk group had significantly more CD4 + memory T cells and resting myeloid dendritic cells, and subjects in the high-risk group had more plasma B cells and monocytes. The risk assessment model constructed using FRLs showed good predictive value for the prognosis of patients with PTC.
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Data availability
All data generated or analyzed during this study are included in this article. Further inquiries can be directed to the corresponding authors.
Abbreviations
- lncRNAs:
-
Long non-coding RNAs
- PTC:
-
Papillary thyroid carcinoma
- FRLs:
-
Ferroptosis-related lncRNAs
- PCC:
-
Pearson correlation coefficient
- FRLM:
-
FRL model
- GSEA:
-
Gene set enrichment analysis
- NES:
-
Normalized enrichment score
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This study was sponsored by Shanghai Sailing Program (No.20YF359).
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WX and YL: conceived and designed the study, acquired the data, and drafted the manuscript. HY and HQ: analyzed and interpreted the data and helped draft the manuscript. All the authors have read and approved the final version of the manuscript.
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Xiao, W., Lai, Y., Yang, H. et al. Predictive Role of a Novel Ferroptosis-Related lncRNA Pairs Model in the Prognosis of Papillary Thyroid Carcinoma. Biochem Genet 62, 775–797 (2024). https://doi.org/10.1007/s10528-023-10447-0
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DOI: https://doi.org/10.1007/s10528-023-10447-0