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Association of the Common Catalase Gene Polymorphism rs1001179 With Glycated Hemoglobin and Plasma Lipids in Hyperlipidemic Patients

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Abstract

Catalase represents perhaps the most effective antioxidant defense in the body under conditions of increased oxidative stress, and rs1001179 (CAT-262C >T) is its most extensively studied gene polymorphism. Using an established PCR–RFLP method for genotyping, we examined the association of rs1001179 with glycated hemoglobin (HbA1c) and plasma lipids using univariate analyses with age, sex, body mass index (BMI), smoking, and alcohol abuse as covariates, in a group of dyslipidemic patients from northern Greece. Our results suggest that the TT genotype is a risk factor for increased HbA1c and plasma triglycerides, and that this association is modulated by the BMI and/or age of the patients.

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Funding

D Agapakis was the recipient of a Grant from the Atherosclerosis Society of Northern Greece (#262/7-5-2010).

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Authors and Affiliations

  1. 1st Laboratory of Pharmacology, Faculty of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece

    Antonis Goulas, Athanassios Apostolidis & Dimitra Gouda

  2. 1st Propedeutic Department of Internal Medicine, AHEPA Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece

    Dimitrios Agapakis, Christos Savopoulos & Apostolos I. Hatzitolios

  3. 3rd Department of Internal Medicine, Papageorgiou Hospital, Faculty of Medicine, Aristotle University of Thessaloniki, 54629, Thessaloniki, Greece

    Sotirios Anastassiadis & Christina Trakatelli

Authors
  1. Antonis Goulas
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  2. Dimitrios Agapakis
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  3. Athanassios Apostolidis
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  4. Dimitra Gouda
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  6. Christina Trakatelli
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  7. Christos Savopoulos
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  8. Apostolos I. Hatzitolios
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Correspondence to Antonis Goulas.

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Goulas, A., Agapakis, D., Apostolidis, A. et al. Association of the Common Catalase Gene Polymorphism rs1001179 With Glycated Hemoglobin and Plasma Lipids in Hyperlipidemic Patients. Biochem Genet 55, 77–86 (2017). https://doi.org/10.1007/s10528-016-9777-2

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  • DOI: https://doi.org/10.1007/s10528-016-9777-2

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