For antibody-based drugs, it is important and relevant to study their toxic effects, which can often become limiting when prescribing this type of therapy. General toxicity of antiviral drug Ergoferon based on technologically processed antibodies was studied on sexually mature animals. Analysis of acute toxicity showed the absence of lethal outcomes when the drug was administered to adult rats at the maximum tolerated doses. In a study of repeated dose toxicity, no adverse effects of the drug were detected.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 5, pp. 581-585, May, 2023
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Danchenko, E.A., Ertuzun, I.A., Bugaeva, L.I. et al. Analysis of General Toxicity of Ergoferon. Bull Exp Biol Med 175, 644–648 (2023). https://doi.org/10.1007/s10517-023-05918-8
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DOI: https://doi.org/10.1007/s10517-023-05918-8