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Antimicrobial Activity of Milk Whey in Different Mammals

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Bulletin of Experimental Biology and Medicine Aims and scope

Antimicrobial activity of milk whey in different mammals against Candida albicans yeast cells was studied by a spectrophotometric method. The activity increased in the order goat→horse→camel→cow→human→mouse. The level of whey activity in mice was higher by 3 and 10 times than in humans and goats, respectively. Similar changes were noted for activity of the whey fraction <100 kDa containing a complex of antimicrobial polypeptides, and there was a direct correlation between these two parameters (r=0.881; p<0.05). The total activity of whey had a high degree of correlation with the content of serum albumin (r=0.992); in mice, the level of serum albumin in the milk whey was close to that in blood serum. Interspecific differences between the activity of whey in mammals may be associated with qualitative and quantitative variability of the antimicrobial polypeptide composition, as well as their synergistic or antagonistic interaction with each other.

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Authors and Affiliations

  1. Department of Microbiology, Virology, and Immunology, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    T. I. Kolyganova & P. O. Shatunova

  2. I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia

    T. I. Kolyganova, V. G. Arzumanyan, P. O. Shatunova & N. E. Yastrebova

  3. All-Russian Research Institute of Horse Breeding, Divovo, Rybnovsky district, Ryazan region, Russia

    M. A. Matvienko & A. A. Rodionova

  4. Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia

    D. S. Korshunova

Authors
  1. T. I. Kolyganova
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  2. V. G. Arzumanyan
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  3. M. A. Matvienko
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  4. A. A. Rodionova
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  5. D. S. Korshunova
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  6. P. O. Shatunova
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  7. N. E. Yastrebova
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Corresponding author

Correspondence to T. I. Kolyganova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 3, pp. 340-344, March, 2023

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Kolyganova, T.I., Arzumanyan, V.G., Matvienko, M.A. et al. Antimicrobial Activity of Milk Whey in Different Mammals. Bull Exp Biol Med 175, 358–361 (2023). https://doi.org/10.1007/s10517-023-05867-2

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  • DOI: https://doi.org/10.1007/s10517-023-05867-2

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