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Circulating angiopoietin-2 levels in children and adolescents with type 1 diabetes mellitus: relation to carotid and aortic intima-media thickness

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Abstract

Background

Angiopoietin-2 is a growth factor involved in the pathophysiology of vascular and inflammatory diseases such as arteriosclerosis. Carotid or aortic scans provide noninvasive screening tools for assessment of preclinical atherosclerosis in high-risk children.

Aim

We assessed serum angiopoietin-2 in children and adolescents with type 1 diabetes mellitus as a potential marker for vascular complications in relation to glycemic control, inflammation and vascular structure.

Methods

Sixty patients with type 1 diabetes were divided into 2 groups according to the presence of micro-vascular complications and compared with 30 healthy controls. High-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), urinary albumin/creatinine ratio, serum angiopoietin-2, carotid and aortic intima-media thickness (CIMT and AIMT) were measured.

Results

CIMT, AIMT and serum angiopoietin-2 levels were significantly increased in patients with and without micro-vascular complications compared with controls, and the highest levels were in patients with complications (p < 0.001). Angiopoietin-2 was higher in patients with microalbuminuria than normoalbuminuric group (p < 0.001). Fasting blood glucose, HbA1c, hs-CRP, CIMT and AIMT were independently related to angiopoietin-2 in multiple regression analysis. Disease duration, hyperglycemia, poor glycemic control, hypercholesterolemia, inflammation and angiopoietin-2 were independent factors contributing to atherosclerosis risk.

Conclusion

The relation between angiopoietin-2 and assessed parameters of vascular structure in type 1 diabetes reflects a state of endothelial injury and highlights the role of disturbed angiogenesis and vascular inflammation in the occurrence of diabetic complications.

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Authors and Affiliations

  1. Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Mohamed Abo El-Asrar, Nancy Samir Elbarbary & AlShaimaa Abo Bakr

  2. Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Eman Abdel Rahman Ismail

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  1. Mohamed Abo El-Asrar
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  2. Nancy Samir Elbarbary
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  3. Eman Abdel Rahman Ismail
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  4. AlShaimaa Abo Bakr
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Correspondence to Nancy Samir Elbarbary.

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El-Asrar, M.A., Elbarbary, N.S., Ismail, E.A.R. et al. Circulating angiopoietin-2 levels in children and adolescents with type 1 diabetes mellitus: relation to carotid and aortic intima-media thickness. Angiogenesis 19, 421–431 (2016). https://doi.org/10.1007/s10456-016-9517-6

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  • DOI: https://doi.org/10.1007/s10456-016-9517-6

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