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Effect of Angiogenesis in Bone Tissue Engineering

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Abstract

The reconstruction of large skeletal defects is still a tricky challenge in orthopedics. The newly formed bone tissue migrates sluggishly from the periphery to the center of the scaffold due to the restrictions of exchange of oxygen and nutrition impotent cells osteogenic differentiation. Angiogenesis plays an important role in bone reconstruction and more and more studies on angiogenesis in bone tissue engineering had been published. Promising advances of angiogenesis in bone tissue engineering by scaffold designs, angiogenic factor delivery, in vivo prevascularization and in vitro prevascularization are discussed in detail. Among all the angiogenesis mode, angiogenic factor delivery is the common methods of angiogenesis in bone tissue engineering and possible research directions in the future.

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Funding

The author(s) received partial financial support for the research by Jiangsu Commission of Health M2020025.

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Authors and Affiliations

  1. Department of Orthopedics, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, People’s Republic of China

    Jianhao Huang & Guangxin Zhou

  2. Department of Orthopedics, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, People’s Republic of China

    Qixiu Han, Jie Zhu, Zhen Wang & Jingwei Lu

  3. Department of Orthopedics, Jinling Hospital, School of Medicine, Southeast University, Nanjing, 210002, People’s Republic of China

    Meng Cai

  4. State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, People’s Republic of China

    Lan Li

  5. Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, People’s Republic of China

    Lingfeng Yu & Guangxin Zhou

  6. Department of Orthopedics, Nanjing Jinling Hospital, 305 Zhongshan East Road, Nanjing, 210002, People’s Republic of China

    Gentao Fan, Yan Zhu, Jingwei Lu & Guangxin Zhou

  7. The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, People’s Republic of China

    Guangxin Zhou

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  1. Jianhao Huang
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Correspondence to Jingwei Lu or Guangxin Zhou.

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Huang, J., Han, Q., Cai, M. et al. Effect of Angiogenesis in Bone Tissue Engineering. Ann Biomed Eng 50, 898–913 (2022). https://doi.org/10.1007/s10439-022-02970-9

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