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Clinicopathologic and survival analysis of patients with adenoid cystic carcinoma of vulva: single-institution experience

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Abstract

Purpose

The purpose of this study was to elucidate our experience in the diagnosis and treatment of adenoid cystic carcinoma of the vulva (ACC-vulva) and to assess the clinicopathological characteristics and prognosis among ACC-vulva patients.

Methods

A retrospective study of seventeen patients was performed to illustrate the demographic information, clinical performance, pathological characteristics, treatment modality, and development of local recurrence or distant metastasis, as well as the survival outcome.

Results

The median age at diagnosis was 56 years (range, 26–71 years). Radical local excision was performed on fifteen patients, and two patient received radical hemi-vulvectomy. Six patients received ipsilateral inguinal lymphadenectomy. Involvement of the resection margin was observed in six patients. The postoperative pathologic diagnosis showed no proof of inguinal lymph node metastasis in all the six patients receiving lymphadenectomy. However, the perineural invasion was observed in all patients. Postoperative adjuvant radiotherapy was applied to five patients who had positive resection margin. The mean survival time except for that in four patients (recent case) was 47.8 months (range, 23–78 months).

Conclusion

Radical resection towards negative margins seems to be acceptable as initial treatment. Adjuvant radiotherapy is a preferable treatment modality for patients with high-risk factors pathologically or patients with local recurrence.

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All data generated or used during the study appear in the submitted article.

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Acknowledgements

We’d like to show our sincere gratitude to all the faculty members in our department and all the patients and their families involved in the current study.

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Authors and Affiliations

  1. Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China

    Jun Zhu, Lina Yin, Xiaohua Wu & Guihao Ke

  2. Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China

    Qifeng Wang

  3. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

    Jun Zhu, Lina Yin, Xiaohua Wu & Guihao Ke

Authors
  1. Jun Zhu
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  2. Lina Yin
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  3. Qifeng Wang
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  4. Xiaohua Wu
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  5. Guihao Ke
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Contributions

JZ, GK: Protocol development. JZ, LY: Data collection or management. JZ: Data analysis. JZ, LY, QW, XW & GK: Manuscript writing/editing.

Corresponding author

Correspondence to Guihao Ke.

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The authors declare that they have no conflict of interest.

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Zhu, J., Yin, L., Wang, Q. et al. Clinicopathologic and survival analysis of patients with adenoid cystic carcinoma of vulva: single-institution experience. Int J Clin Oncol 25, 2144–2150 (2020). https://doi.org/10.1007/s10147-020-01764-0

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  • DOI: https://doi.org/10.1007/s10147-020-01764-0

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