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Hypertensive primary intraventricular hemorrhage: a systematic review

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Abstract

Primary intraventricular hemorrhage (PIVH) is a special subtype of intraventricular hemorrhage (IVH) without a hemorrhagic parenchymal component. Different conditions may cause this uncommon hemorrhage including trauma, vascular anomalies, coagulation disorders, and others. Frequently, PIVH is associated with structural vascular anomalies such as aneurysms, arteriovenous malformations, and dural fistulas. Traditionally, hypertension has been considered a predisposing factor for PIVH. A wide variety of studies have been published describing patients with PIVH; however, studies describing exclusively patients with hypertensive PIVH are lacking in the literature. For this reason, the features of PIVH secondary to hypertension are not well described. The purpose of this study is to analyze and describe the characteristics of hypertensive PIVH. A PubMed and Scopus search adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was performed to include studies reporting patients with hypertensive PIVH. The search yielded 19 articles reporting retrospective case series. The diagnosis of hypertensive PIVH should be established in patients meeting the following criteria: (a) elevation of blood pressure is observed at admission, (b) a cerebral angiography is negative for vascular anomalies, and (c) other causes of intracranial hemorrhage are ruled out. The prognosis is poorer in patients who present with low Glasgow Coma Score (GCS), old age, hydrocephalus, or more extensive intraventricular bleeding. The results of this study show that hypertension is the most common cause of PIVH, followed by hemorrhage caused by vascular anomalies. Hypertension may be a direct cause of PIVH, but also it may be a predisposing factor for bleeding in cases of an associated vascular anomaly.

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Authors and Affiliations

  1. Section of Neurosurgery, Hospital Joya, Av. Francisco Medina Ascencio 2760, CP 48333, Puerto Vallarta, Jalisco, Mexico

    Luis A. Robles

  2. Department of Neurosurgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands

    Victor Volovici

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  1. Luis A. Robles
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  2. Victor Volovici
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Contributions

L.A.R designed the study. L.A.R. and V.V. collected and analyzed the data and drafted and revised the manuscript. V.V analyzed the data, interpreted the results, and performed the statistical analysis. L.A.R. and V.V. revised the final manuscript.

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Correspondence to Luis A. Robles.

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Robles, L.A., Volovici, V. Hypertensive primary intraventricular hemorrhage: a systematic review. Neurosurg Rev 45, 2013–2026 (2022). https://doi.org/10.1007/s10143-022-01758-8

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