Abstract
This study ascertained to explore the potential contribution of ARRDC3 polymorphisms in the risk and prognosis of glioma. One thousand sixty-one patients and healthy controls were conducted to assess whether ARDC3 polymorphism was associated with glioma risk and prognosis. Four sites in ARRDC3 were selected and genotyped in MassARRAY platform. The calculated odd ratios and 95% confidence intervals from logistic regression were applied for risk assessment. The relationship between ARRDC3 variants and glioma prognosis was evaluated using log-rank test, Kaplan–Meier analysis, and so on. Also, false-positive report probability (FPRP) and statistical power were also assessed. Our findings suggested the negative role of ARRDC3 polymorphisms in the glioma risk. We also found the effect of candidate SNPs in ARRDC3 on the susceptibility to glioma was dependent on the age, gender, and histology of glioma patients. The results suggested that the genetic polymorphisms of ARRDC3 were related to an increased risk of glioma.
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The datasets used and analyzed in our current study are available from corresponding author for all reasonable request.
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SG and YS designed the project and took part in revising the manuscript. PH, LG, and YS performed sample collection. NL and HS completed the experiments, writing and revising the manuscript. WD, LW, and TJ performed data management. WM, GZ, and NW took part in data analysis. SG supervised the project.
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Nan Li and Hangyu Shi are co-first authors.
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Li, N., Shi, H., Hou, P. et al. ARRDC3 polymorphisms may affect the risk of glioma in Chinese Han. Funct Integr Genomics 22, 27–33 (2022). https://doi.org/10.1007/s10142-021-00807-7
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DOI: https://doi.org/10.1007/s10142-021-00807-7