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The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid

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Abstract

Fungal infections due to Apiotrichum mycotoxinivorans are clinically rare. Here, we report a case of invasive blood and cerebrospinal fluid infection by Apiotrichum mycotoxinivorans in a girl with B-cell acute lymphoblastic leukemia. This is the first report of the isolation of Apiotrichum mycotoxinivorans from human cerebrospinal fluid. MRI features of meningitis caused by this fungus are presented. Three small isoquinoline alkaloids inhibited the growth of this rare fungus in vitro, providing a starting point for the application of natural products to treat this highly fatal fungal infection. Our case presentation confirms Apiotrichum mycotoxinivorans as a potential emerging pathogen in patients with hematological malignancy undergoing chemotherapy.

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Availability of data and material

The datasets generated during and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.

Funding

This work was supported by the Science and Technology Department of National Administration of Traditional Chinese Medicine and Health Commission of Shandong Province jointly established the traditional Chinese medicine science and technology project (Grant no. GZY-KJS-SD-2023-065), Research fund of China Maternal and Child Health Research Association (Grant no. 2023CAMCHS003A11), Shandong Provincial Natural Science Foundation (Grant no. ZR2020QH365), the hospital level project of Shandong Province Maternal and Child Health Hospital (Grant no. 2021sf004), and Shandong Provincial Clinical Medical Research Center for Children’s Health and Diseases—multidisciplinary collaboration to carry out clinical promotion and research on the precision diagnosis and treatment of children with infectious diseases (Grant no. RC006).

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Authors and Affiliations

  1. Maternal and Child Health Development Research Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, China

    Xiuyun Li & Dong Wang

  2. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China

    Xiuyun Li

  3. Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan, 250014, China

    Mingju Hao

  4. Microbiology Laboratory, Children’s Hospital Affiliated to Shandong University, Jinan, 250022, China

    Zheng Li, Chunyan Zhang & Shifu Wang

  5. Shandong Provincial Clinical Research Center for Children’s Health and Disease, No. 23976 Jingshi Road, Jinan, 250022, China

    Zheng Li, Chunyan Zhang & Shifu Wang

  6. Pediatric Surgery, Liaocheng Dongchangfu District Maternal and Child Health Hospital, Liaocheng, 252000, China

    Shulong Feng

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  1. Xiuyun Li
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Correspondence to Shifu Wang.

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The authors declare no competing interests.

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The funding organizations provided funds for the purchase of laboratory supplies for our study but had no role in the design of the study and the collection, analysis, and interpretation of the data.

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Li, X., Wang, D., Hao, M. et al. The first report of Apiotrichum mycotoxinivorans isolation from human cerebrospinal fluid. Eur J Clin Microbiol Infect Dis 43, 597–604 (2024). https://doi.org/10.1007/s10096-023-04736-0

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  • DOI: https://doi.org/10.1007/s10096-023-04736-0

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