Abstract
The objective of this study was to evaluate antimicrobial therapy outcomes of bone and joint infections (BJI) caused by Clostridium perfringens. We investigated remission of symptoms and the absence of relapse or reinfection during follow-up. Among the 8 patients with C. perfringens BJI, the type of infection was early prosthesis infection (n = 2), osteosynthetic device infection (n = 4), and chronic osteomyeletis (n = 2). Clindamycin-rifampicin combination was given in 4 cases and metronidazole in 4 cases. The overall success rate was 87.5%. Among the 7 patients who completed antibiotic treatment, the success rate was 100%. The clindamycin-rifampicin combination appeared to be effective in patients with C. perfringens BJI.
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Yes. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Acknowledgements
We thank Fiona Ecarnot, PhD (EA3920, University Hospital Besancon, France) for editorial assistance.
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All authors cared for the patients. FBS, VVG, and SD were responsible for the overall supervision of the study. MV and FBS wrote the first manuscript draft. All authors critically reviewed the manuscript and gave final approval. FBS was responsible for the overall supervision of the study.
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Only parameters collected in routine clinical practice for which patients give their informed consent on admission to the hospital were retrospectively analyzed. Approval by an ethics committee was not required in accordance with French legislation.
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Visse, M., Vernet-Garnier, V., Bajolet, O. et al. Bone and joint infections caused by Clostridium perfringens: a case series. Eur J Clin Microbiol Infect Dis 40, 2221–2225 (2021). https://doi.org/10.1007/s10096-021-04225-2
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DOI: https://doi.org/10.1007/s10096-021-04225-2