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Impaired interhemispheric synchrony and effective connectivity in right temporal lobe epilepsy

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Abstract

Background

The brain functional network plays a crucial role in cognitive impairment in temporal lobe epilepsy (TLE). Based on voxel-mirrored homotopic connectivity (VMHC), this study explored how directed functional connectivity changes and is associated with impaired cognition in right TLE (rTLE).

Methods

Twenty-seven patients with rTLE and twenty-seven healthy controls were included to perform VMHC and Granger causality analysis (GCA). Correlation analysis was performed based on GCA and cognitive function.

Results

Bilateral middle frontal gyrus (MFG), middle temporal gyrus, dorsolateral superior frontal gyrus (SFGdor), and supramarginal gyrus (SMG) exhibited decreased VMHC values in the rTLE group. Brain regions with altered VMHC had abnormal directed functional connectivity with multiple brain regions, mainly belonging to the default mode network, sensorimotor network, and visual network. Besides, the Montreal Cognitive Assessment (MoCA) score was positively correlated with the connectivity from the left SFGdor to the right cerebellum crus2 and was negatively correlated with the connectivity from the left SMG to the right supplementary motor area (SMA) before correction. Before correction, both phasic and intrinsic alertness reaction time were positively correlated with the connectivity from the left MFG to the left precentral gyrus (PreCG), connectivity from the left SMG to the right PreCG, and the connectivity from the left SMG to the right SMA. The executive control effect reaction time was positively correlated with the connectivity from the left MFG to the left calcarine fissure surrounding cortex before correction.

Conclusion

The disordered functional network tended to be correlated with cognition impairment in rTLE.

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Data availability

Data is available upon request.

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Acknowledgements

The authors would like to express their gratitude to EditSprings (https://www.editsprings.com/) for the expert linguistic services provided. A previous version of this manuscript has been preprinted on Authorea (https://doi.org/10.22541/au.167146514.42115408/v1).

Funding

The work is supported by the Natural Science Foundation of Guangxi Province (2018GXNSFAA050149).

Author information

Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

    Ke Shi, Lu Yu, Zhekun Li, Chunyan Li, Qijia Long & Jinou Zheng

  2. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Yiling Wang

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  1. Ke Shi
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  2. Lu Yu
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  3. Yiling Wang
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  4. Zhekun Li
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  5. Chunyan Li
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  7. Jinou Zheng
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Contributions

The contributions are as follows. Ke Shi: data analysis and writing of the paper draft. Lu Yu: methodology and modification of paper draft. Yiling Wang: literature research and visualization. Zhekun Li, Chunyan Li, and Qijia Long: data acquisition. Jinou Zheng: conceptualization, study design, and supervision.

Corresponding author

Correspondence to Jinou Zheng.

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This study was approved by the Medical Research Ethics Committee of the First Affiliated Hospital of Guangxi Medical University (2020-KY-GUOJI-010).

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The authors declare no competing interests.

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Shi, K., Yu, L., Wang, Y. et al. Impaired interhemispheric synchrony and effective connectivity in right temporal lobe epilepsy. Neurol Sci 45, 2211–2221 (2024). https://doi.org/10.1007/s10072-023-07198-6

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