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Uric acid levels and their association with vascular dementia and Parkinson’s disease dementia: a meta-analysis

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Abstract

Objectives

To explore the association between uric acid (UA) levels and vascular dementia (VaD) and Parkinson’s disease dementia (PDD), a meta-analysis was conducted.

Methods

The relevant studies were identified by searching PubMed, Embase, Web of Science, and Cochrane Collaboration Database up to May 2022. Pooled analysis, sensitivity analysis, and publication bias examination were all conducted. All analyses were performed by using STATA 16.

Results

Twelve studies with a total of 2097 subjects were included. The pooled analysis showed that UA levels were not associated with VaD (WMD =  - 10.99 μmol/L, 95% CI (- 48.05, 26.07), P = 0.561) but were associated with PDD (WMD =  - 25.22 μmol/L, 95% CI (- 43.47, - 6.97), P = 0.007). The statistical stability and reliability were evaluated using sensitivity analysis and publication bias outcomes.

Conclusion

UA levels are associated with PDD but not with VaD. This study will help to strengthen our knowledge of the pathophysiologies of VaD and PDD, and promote the development of prevention and treatment strategies.

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Data availability

All data generated or analyzed during this study are included in this article. Further enquiries can be directed to the corresponding author.

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Acknowledgements

We are appreciative of all the participants in this study.

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Authors and Affiliations

  1. School of Public Health, Shenyang Medical College, 146 Huanghe North Street, Shenyang, 110034, China

    Qian Li, Kaiwen Cen, Ying Cui, Xu Feng & Xiaowen Hou

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  1. Qian Li
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  3. Ying Cui
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Contributions

Qian Li wrote the first draft, searched the literature, and extracted the data. Kaiwen Cen and Ying Cui searched the literature and extracted the data. Xu Feng conducted the data analysis. Xiaowen Hou designed the study and revised the manuscript.

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Correspondence to Xiaowen Hou.

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Li, Q., Cen, K., Cui, Y. et al. Uric acid levels and their association with vascular dementia and Parkinson’s disease dementia: a meta-analysis. Neurol Sci 44, 2017–2024 (2023). https://doi.org/10.1007/s10072-023-06620-3

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  • DOI: https://doi.org/10.1007/s10072-023-06620-3

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