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Association between freezing of gait and bone mineral density in patients with Parkinson’s disease

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Abstract

Parkinson’s disease (PD) patients are at risk for developing bone health problems, and freezing of gait (FOG) in PD is associated with a high risk of falling and fracture. This study aimed to determine the association between FOG and bone mineral density (BMD) in patients with PD. We included 148 PD patients. FOG was assessed using the FOG Questionnaire (FOG-Q), and BMD was measured by dual-energy X-ray absorptiometry. Of 148 PD patients, 102 (68.9%) had FOG. PD patients with FOG were older and had longer disease duration, higher levodopa equivalent dose, higher modified Hoehn and Yahr stage, higher Unified PD Rating Scale motor score, higher FOG-Q score, higher total Non-Motor Symptom Scale score, and lower BMD scores in the femoral neck area than those without FOG. Pearson correlation analysis revealed that age, sex, body mass index, and age at onset were significantly correlated with areal BMDs in all areas. FOG-Q scores correlated negatively with areal BMDs in the total hip area and femoral neck, but not with areal BMD in the lumbar spine. Multivariate regression analysis showed that FOG-Q score was significantly correlated with areal BMD in the femoral neck, but not with areal BMDs in the lumbar spine or total hip. FOG in PD patients correlates significantly with BMD in the femoral neck area. Therefore, PD patients with FOG should be screened for osteoporosis.

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Funding

This research was supported by the KBRI basic research program through Korea Brain Research Institute funded by the Ministry of Science and ICT (19-BR-03-04).

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Authors and Affiliations

  1. Department of Neurology, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 58128, South Korea

    Seong-Min Choi, Soo Hyun Cho & Byeong C. Kim

  2. National Research Center for Dementia, Gwangju, South Korea

    Seong-Min Choi & Byeong C. Kim

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  1. Seong-Min Choi
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  2. Soo Hyun Cho
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  3. Byeong C. Kim
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Correspondence to Byeong C. Kim.

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The authors declare that they have no conflicts of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Institutional Review Board of the hospital, and informed consent was obtained from the study participants.

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Choi, SM., Cho, S.H. & Kim, B.C. Association between freezing of gait and bone mineral density in patients with Parkinson’s disease. Neurol Sci 42, 2921–2925 (2021). https://doi.org/10.1007/s10072-020-04920-6

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  • DOI: https://doi.org/10.1007/s10072-020-04920-6

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