Abstract
Intelligent controlled release technologies that rely on environmental changes to control the release rate of antimicrobial agents have attracted attention in the field of food preservation. In this paper, cinnamaldehyde (CN) was grafted onto chitosan (CS) to form a pH-responsive controlled-release complex, CS–CN, via the Schiff base reaction. Then, tempo oxidized cellulose nanofibers (CNF) and PVA were prepared as aerogels loaded with CS–CN with different pore parameters (PCNF@CN). Release experiments showed that acid triggered the release of CN and increased the release from 10.3 to 68.4% with increasing pH. In addition, PCNF@CN showed significant pH-responsive antimicrobial properties against Escherichia coli and Staphylococcus aureus. Utilizing the water absorption of the aerogel and triggering the release of CN, the shelf life of fresh meat could be delayed for 4 days. This study demonstrated the potential application of PCNF@CN aerogel in functional food preservation packaging.
Similar content being viewed by others
References
Ahmad H, Anguilano L, Fan M. Microstructural architecture and mechanical properties of empowered cellulose-based aerogel composites via TEMPO-free oxidation. Carbohydrate Polymers. 298: 120117 (2022)
Anush SM, Vishalakshi B, Kalluraya B, Manju N. Synthesis of pyrazole-based Schiff bases of chitosan: evaluation of antimicrobial activity. International Journal of Biological Macromolecules. 119: 446-452 (2018)
Bhandari J, Mishra H, Mishra PK, Wimmer R, Ahmad FJ, Talegaonkar S. Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery. International Journal of Nanomedicine. 12: 2021-2031 (2017)
Chabbi J, Aqil A, Katir N, Vertruyen B, Jerôme C, Lahcini M, El Kadib A. Aldehyde-conjugated chitosan-graphene oxide glucodynamers: ternary cooperative assembly and controlled chemical release. Carbohydrate Polymers. 230: 115634 (2020)
Chen L, Niu X, Fan X, Liu Y, Yang J, Xu X, Zhou G, Zhu B, Ullah N, Feng X. Highly absorbent antibacterial chitosan-based aerogels for shelf-life extension of fresh pork. Food Control. 136: 108644 (2022)
Cionti C, Taroni T, Sabatini V, Meroni D. Nanostructured oxide-based systems for the pH-triggered release of cinnamaldehyde. Materials. 14: 1536 (2021)
Cui H, Cheng Q, Li C, Khin MN, Lin L. Schiff base cross-linked dialdehyde β-cyclodextrin/gelatin-carrageenan active packaging film for the application of carvacrol on ready-to-eat foods. Food Hydrocolloids. 141: 108744 (2023)
Hassan MA, Omer AM, Abbas E, Baset WMA, Tamer TM. Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives. Scientific Reports. 8: 11416 (2018)
Heras-Mozos R, Gavara R, Hernández-Muñoz P. Responsive packaging based on imine-chitosan films for extending the shelf-life of refrigerated fresh-cut pineapple. Food Hydrocolloids. 133: 107968 (2022)
Jabbari-Gargari A, Moghaddas J, Jafarizadeh-Malmiri H, Hamishehkar H. Ambient pressure drug loading on trimethylchlorosilane silylated silica aerogel in aspirin controlled-release system. Chemical Engineering Communications. 209: 1612-1625 (2022)
Jin J, Hanefeld U. The selective addition of water to CC bonds; enzymes are the best chemists. Chemical Communications. 47: 2502-2510 (2011)
Jose J, Pai AR, Gopakumar DA, Dalvi Y, Ruby V, Bhat SG, Pasquini D, Kalarikkal N, Thomas S. Novel 3D porous aerogels engineered at nano scale from cellulose nano fibers and curcumin: an effective treatment for chronic wounds. Carbohydrate Polymers. 287: 119338 (2022)
Lee S, Kim S, Bang W, Yuk H. Combined antibacterial effect of 460 nm light-emitting diode illumination and chitosan against Escherichia coli O157:H7, Salmonella spp. and Listeria monocytogenes on fresh-cut melon, and the impact of combined treatment on fruit quality. Food Science and Biotechnology. (2023) https://doi.org/10.1007/s10068-023-01324-y.
Lin W-H, Jana SC. Analysis of porous structures of cellulose aerogel monoliths and microparticles. Microporous and Mesoporous Materials. 310: 110625 (2021)
Long L-Y, Weng Y-X, Wang Y-Z. Cellulose aerogels: synthesis, applications, and prospects. Polymers. 10: 623 (2018)
Malekshah RE, Shakeri F, Aallaei M, Hemati M, Khaleghian A. Biological evaluation, proposed molecular mechanism through docking and molecular dynamic simulation of derivatives of chitosan. International Journal of Biological Macromolecules. 166: 948-966 (2021)
Meng Q, Xue Z, Chen S, Wu M, Lu P. Smart antimicrobial Pickering emulsion stabilized by pH-responsive cellulose-based nanoparticles. International Journal of Biological Macromolecules. 233: 123516 (2023)
Ni L, Yang X. Determination of cinnamaldehyde and piperine in Shiliu Jianwei pill by HPLC. Chinese Journal of Modern Applied Pharmacy. 29: 67-69 (2012)
Ooi L, Li Y, Kam S, Wang H, Wong E, Ooi V. Antimicrobial activities of cinnamon oil and cinnamaldehyde from the Chinese medicinal herb Cinnamomum cassia Blume. American Journal of Chinese Medicine. 34: 511-522 (2006)
Rincón E, Espinosa E, Pinillos M, Serrano L. Bioactive absorbent chitosan aerogels reinforced with bay tree pruning waste nanocellulose with antioxidant properties for burger meat preservation. Polymers. 15: 866 (2023)
Rodríguez-Núñez JR, López-Cervantes J, Sánchez-Machado DI, Ramírez-Wong B, Torres-Chavez P, Cortez-Rocha MO. Antimicrobial activity of chitosan-based films against Salmonella typhimurium and Staphylococcus aureus. International Journal of Food Science & Technology. 47: 2127-2133 (2012)
Shen S, Zhang T, Yuan Y, Lin S, Xu J, Ye H. Effects of cinnamaldehyde on Escherichia coli and Staphylococcus aureus membrane. Food Control. 47: 196-202 (2015)
Si R, Wu C, Yu D, Ding Q, Li R. Novel TEMPO-oxidized cellulose nanofiber/polyvinyl alcohol/polyethyleneimine nanoparticles for Cu2+ removal in water. Cellulose. 28: 10999-11011 (2021)
Takeno H, Inoguchi H, Hsieh W-C. Mechanical and structural properties of cellulose nanofiber/poly(vinyl alcohol) hydrogels cross-linked by a freezing/thawing method and borax. Cellulose. 27: 4373-4387 (2020)
Tamer TM, ElTantawy MM, Brussevich A, Nebalueva A, Novikov A, Moskalenko IV, Abu-Serie MM, Hassan MA, Ulasevich S, Skorb EV. Functionalization of chitosan with poly aromatic hydroxyl molecules for improving its antibacterial and antioxidant properties: practical and theoretical studies. International Journal of Biological Macromolecules. 234: 123687 (2023)
Valero A, Pérez-Rodríguez F, Carrasco E, Fuentes-Alventosa JM, García-Gimeno RM, Zurera G. Modelling the growth boundaries of Staphylococcus aureus: effect of temperature, pH and water activity. International Journal of Food Microbiology. 133: 186-194 (2009)
Wang S, Wang F, Lu C, Ma S, Gu Y, Wang L. Citral-loaded nanocellulose/sodium alginate aerogel packaging liner for fresh pork preservation. Food Control. 155: 110031 (2024)
Wang L, Xu J, Zhang M, Zheng H, Li L. Preservation of soy protein-based meat analogues by using PLA/PBAT antimicrobial packaging film. Food Chemistry. 380: 132022 (2022a)
Wang P, Zou Y, Li Y, Qin Z, Liu X, Zhang H. pH-sensitive self-assembled nanofibers based on electrostatic interaction and Schiff base bonding for controlled release of curcumin. Food Hydrocolloids. 131: 107805 (2022b)
Wei C, Fan C, Xie D, Zhou S, Zhang H, Du Q, Jin P. Fabrication of cinnamaldehyde-entrapped ethosome nanoparticles as antimicrobial agent. LWT 181: 114760 (2023)
Wu W. Facile fabrication of multifunctional citrus pectin aerogel fortified with cellulose nanofiber as controlled packaging of edible fungi. Food Chemistry. 374: 131763 (2022)
Wu C, Wang L, Fang Z, Hu Y, Chen S, Sugawara T, Ye X. The effect of the molecular architecture on the antioxidant properties of chitosan gallate. Marine Drugs. 14: 95 (2016)
Xu J, Liu Y, Hsu S. Hydrogels based on Schiff base linkages for biomedical applications. Molecules. 24: 3005 (2019)
Xu J, Song W, Wu N, Tong J, Ren L. Preparation and characterization of chitosan/polyvinyl porous alcohol aerogel microspheres with stable physicochemical properties. International Journal of Biological Macromolecules. 187: 614-623 (2021)
Zhang Z, He C, Chen X. Hydrogels based on pH-responsive reversible carbon–nitrogen double-bond linkages for biomedical applications. Materials Chemistry Frontiers. 2: 1765-1778 (2018)
Zhang Y, Liu X, Wang Y, Jiang P, Quek S. Antibacterial activity and mechanism of cinnamon essential oil against Escherichia coli and Staphylococcus aureus. Food Control 59: 282-289 (2016)
Zhang A, Zou Y, Xi Y, Wang P, Zhang Y, Wu L, Zhang H. Fabrication and characterization of bamboo shoot cellulose/sodium alginate composite aerogels for sustained release of curcumin. International Journal of Biological Macromolecules. 192: 904-912 (2021)
Zhao R, E S, Ning D, Ma Q, Geng B, Lu Z. Strengthening and toughening of TEMPO-oxidized cellulose nanofibers/polymers composite films based on hydrogen bonding interactions. Composites Communications. 35: 101322 (2022)
Zhou T, Cheng X, Pan Y, Li C, Gong L. Mechanical performance and thermal stability of polyvinyl alcohol–cellulose aerogels by freeze drying. Cellulose. 26: 1747-1755 (2019)
Zhou Z, Yao Y, Zhang J, Shen L, Xu H, Liu J, Shentu B. Effects of poly(vinyl alcohol) (PVA) concentration on rheological behavior of TEMPO-mediated oxidized cellulose nanofiber/PVA suspensions. Cellulose. 29: 8255-8263 (2022)
Zhu J, Huang T, Chen X, Tian D, Wang L, Gao R. Preparation and characterization of vanillin-conjugated chitosan-stabilized emulsions via a Schiff-base reaction. Food Science and Biotechnology. (2023) https://doi.org/10.1007/s10068-023-01277-2.
Acknowledgements
This work is supported by Fundamental Scientific Research Funds of Central Universities (JUSRP21115); Independent Research Project Funding Project of Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment Technology (FMZ201902); Postgraduate Research & Practice Innovation Program of Jiangsu Province (1072050205238200); Postgraduate Research & Practice Innovation Program of Jiangsu Province (1075212042230360).
Author information
Authors and Affiliations
Contributions
TH: investigation and writing of manuscript. FW: conceptualization and validation. LW: project administration, writing—review and editing. All authors reviewed and commented on manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no conflicts of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Hou, T., Wang, F. & Wang, L. Facile preparation of pH-responsive antimicrobial complex and cellulose nanofiber/PVA aerogels as controlled-release packaging for fresh pork. Food Sci Biotechnol 33, 1871–1883 (2024). https://doi.org/10.1007/s10068-023-01487-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10068-023-01487-8