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Screening value of lung ultrasound and pleural shear wave elastography in connective tissue disease–related interstitial lung disease: a preliminary study

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Abstract

Objective

To explore the diagnostic value of lung ultrasound (LUS) and pleural shear wave elastography (SWE) for connective tissue disease–interstitial lung disease (CTD-ILD).

Methods

We selected 104 patients diagnosed with connective tissue disease (CTD) at our hospital. All patients underwent LUS, SWE, and high-resolution computed tomography (HRCT). With HRCT as the imaging gold standard for diagnosis, patients were categorized into CTD-ILD and CTD-non-ILD groups. We employed paired chi-square tests to compare the diagnostic differences between HRCT and LUS for ILD. Receiver operating characteristic (ROC) curves were used to assess the diagnostic value of pleural SWE for ILD. Correlation analysis was performed between pleural elasticity values and lung ultrasound scores.

Results

The sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of LUS for diagnosing CTD-ILD were 93.3%, 86.2%, 6.761, and 0.078, respectively. There was no statistically significant difference in the results between HRCT and LUS (P = 1.000), with a kappa value of 0.720 (P < 0.001). There was a statistically significant difference in the pleural elasticity in the bilateral lower back region between the case and control groups (P < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for pleural SWE in diagnosing CTD-ILD was 0.685. In CTD-ILD patients, there was no significant correlation between pleural elasticity values and LUS scores (P > 0.05).

Conclusion

The LUS can serve as an important imaging method for screening for CTD-ILD and assessing the severity of the disease. However, pleural SWE has been shown to demonstrate lower diagnostic efficacy for CTD-ILD, and its ability to assess disease severity is limited.

Key Points

• The LUS can serve as an important imaging method for screening for CTD-ILD and assessing the severity of the disease.

• Pleural SWE has been shown to demonstrate lower diagnostic efficacy for CTD-ILD, and its ability to assess disease severity is limited.

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Authors and Affiliations

  1. Department of Ultrasound, The First Hospital of China Medical University, 155 Nanjingbei Street, Heping District, Shenyang, Shenyang, 110004, Liaoning, China

    Shiyao Han, Ziyao Ji & Yanjun Liu

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  1. Shiyao Han
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  2. Ziyao Ji
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  3. Yanjun Liu
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Correspondence to Yanjun Liu.

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Han, S., Ji, Z. & Liu, Y. Screening value of lung ultrasound and pleural shear wave elastography in connective tissue disease–related interstitial lung disease: a preliminary study. Clin Rheumatol 43, 2117–2123 (2024). https://doi.org/10.1007/s10067-024-06983-8

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  • DOI: https://doi.org/10.1007/s10067-024-06983-8

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