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Association of sarcopenia and vitamin D deficiency with glucocorticoid-induced osteoporosis in Chinese patients with rheumatoid arthritis

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Abstract

Objectives

The study aimed to explore the association of sarcopenia and vitamin D deficiency with glucocorticoid-induced osteoporosis (GIOP) in Chinese patients with rheumatoid arthritis (RA).

Method

Skeletal muscle mass, serum 25(OH)D levels, and bone mineral density (BMD) were assessed.

Results

The prevalence of OP, sarcopenia, and vitamin D deficiency in RA patients was significantly higher than in controls (all P < 0.001). The percentage of GC use was 56.9%, and the prevalence of GIOP was 38.1% in 480 RA patients. The prevalence of OP in RA patients without sarcopenia was lower than that in RA patients with sarcopenia (P < 0.05). In RA patients with and without GC, the prevalence of OP in patients without sarcopenia was significantly lower than that in patients with sarcopenia (P < 0.001 and P < 0.05). Female sex (OR = 54.737; 95% CI: 7.103–421.809; P < 0.0001), age (OR = 1.078; 95% CI: 1.048–1.110; P < 0.0001), sarcopenia, and vitamin D deficiency (OR = 2.250; 95% CI: 1.246–64.065; P = 0.007) were risk factors for GIOP in RA patients.

Conclusions

GIOP is associated with sarcopenia and vitamin D deficiency and is widespread among Chinese patients with RA.

Key points

·Percentage of using GC and the prevalence of OP were all high in Chinese patients with RA.

·GIOP was widely existed in Chinese RA patients, which was associated with sarcoprnia and vitamin D deficiency.

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Acknowledgements

We thank all the individuals who have helped us in our study.

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Author notes

  1. Wan-jun Li and Xi-le Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrine Laboratory, The First Affiliated Hospital of Anhui Medical University, No. 218, Ji-xi Road, Hefei, 230022, China

    Wan-jun Li

  2. Department of Rheumatology & Immunology, The First Affiliated Hospital of Anhui Medical University, No. 218, Ji-xi Road, Hefei, 230022, China

    Xi-le Wang, Yi-ran Chu, Jian-xiong Wang & Sheng-qian Xu

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  1. Wan-jun Li
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Li, Wj., Wang, Xl., Chu, Yr. et al. Association of sarcopenia and vitamin D deficiency with glucocorticoid-induced osteoporosis in Chinese patients with rheumatoid arthritis. Clin Rheumatol 43, 15–22 (2024). https://doi.org/10.1007/s10067-023-06784-5

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