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Metabolic abnormalities in rheumatoid arthritis patients with comorbid diabetes mellitus

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Abstract

The metabolic characteristics of rheumatoid arthritis (RA) or diabetes mellitus (DM) have been studied, but the metabolic abnormalities of RA patients complicated with DM are not completely understood. Therefore, we recruited RA patients with DM to investigate the metabolic abnormalities in these patients. We collected data of RA patients with DM and age- and sex-matched RA and DM patients from Changhai Hospital’s electronic medical record system. Data of demographically matched healthy controls were also collected from the health management system of the Hangzhou Sanatorium of People’s Liberation Army. Blood pressure, uric acid, glucose, and lipid levels were compared. The clinical data of RA with DM (n = 104), DM (n = 100), and RA (n = 100) patients and healthy controls (n = 100) were collected and compared. RA patients with DM had higher blood pressure and lower high-density lipoprotein cholesterol levels than the other three groups, a higher triglycerides (TG) level than healthy controls and RA patients, and a lower TG level than DM patients. RA patients with DM exhibited a relatively high proportion of metabolic abnormalities based on existing standards. Our study examined metabolic abnormalities in RA patients with DM for the first time, and our results suggest that clinicians should pay more attention to the metabolic abnormalities of RA patients with DM.

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Acknowledgements

The authors thank all the colleagues of laboratory in Hangzhou Sanatorium of People’s Liberation Army.

Funding

This study was supported by National Natural Science Foundation of China (No. 81671595 and 81471607).

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Author notes

  1. Xing Zhen Liu, Ying Gao and Jie Fan contributed equally to this work.

Authors and Affiliations

  1. Department of Rheumatology and immunology, Changhai Hospital, The Second Military Medical University, No. 168, Changhai Road, Yangpu District, Shanghai, 200433, China

    Xing Zhen Liu, Ying Gao, Xia Xu, Ju Zhang, Jie Gao, Wei Wan & Dong Bao Zhao

  2. Army Convalescence Area, Hangzhou Sanatorium of People’s Liberation Army, Hangzhou, China

    Xing Zhen Liu & Jie Fan

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  1. Xing Zhen Liu
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  2. Ying Gao
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  4. Xia Xu
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  5. Ju Zhang
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  7. Wei Wan
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  8. Dong Bao Zhao
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Corresponding author

Correspondence to Dong Bao Zhao.

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This study was a retrospective study; clinical data collection of patients was approved by the Ethics Committee of the Shanghai Changhai Hospital.

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Liu, X.Z., Gao, Y., Fan, J. et al. Metabolic abnormalities in rheumatoid arthritis patients with comorbid diabetes mellitus. Clin Rheumatol 37, 219–226 (2018). https://doi.org/10.1007/s10067-017-3847-7

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  • DOI: https://doi.org/10.1007/s10067-017-3847-7

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