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The capability of regenerative endodontics to promote the complete root formation in immature permanent teeth with different initial pre-operative conditions

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Abstract

Objectives

To describe the potential possibility of complete root formation after regenerative endodontic procedures (REPs) in immature permanent teeth with different initial pre-operative conditions.

Materials and methods

Children who underwent REPs in the Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, China, from January 2013 to December 2022 were enrolled. Whether the tooth achieved complete root formation was determined using post-operative periapical radiography. The potential possibility of complete root formation after REPs in immature permanent teeth with different initial conditions is discussed.

Results

A total of 428 teeth from 401 patients were included, of which 258 (60.2%) achieved complete root formation. In cases that achieved complete root formation, the most serious type of trauma was avulsion, the teeth with the worst initial root development were less than one-third of the development (stages 6–7), and the longest duration of the presence of apical lesions in the tooth before the first visit was more than 180 days. There is a significant difference in the root formation of teeth with different initial developmental stages and diagnoses.

Conclusions

The active period of continued root formation was 5–21 months post-operatively. The higher the initial stage of root development and the shorter the duration of the presence of apical lesions in the tooth before the first visit, the greater the possibility of root formation. However, complete root formation may still be expected after REPs in severely injured immature permanent teeth and teeth with poor initial pre-operative root development conditions (less than stage 7) at the first visit. This is also true for teeth with long-term and large-scale apical lesions.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Author information

Authors and Affiliations

  1. Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China

    Xijun Jiang & He Liu

Authors
  1. Xijun Jiang
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  2. He Liu
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Xijun Jiang and He Liu. The first draft of the manuscript was written by Xijun Jiang and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to He Liu.

Ethics declarations

Ethics approval and consent to participate

This retrospective study was performed at the Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology. The study protocol was approved by the Ethics Committee of the Peking University School and Hospital of Stomatology (ref. PKUSSIRB-202054062). The informed consent obtained from study participants was written. REPs were explained to all patients and their caregivers. Comprehensive discussions on the risks, complications, and alternative treatment options were conducted, and parental consent was obtained before treatment which explained that data from the procedure would be used for research purposes and that patient anonymity would be protected. All methods were carried out in accordance with relevant guidelines and regulations. All of the regenerative endodontic procedures were performed by experienced faculty members of the department following similar protocols according to the clinical considerations for a regenerative procedure advised by the American Association of Endodontists.

Competing interests

The authors deny any conflicts of interest.

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Jiang, X., Liu, H. The capability of regenerative endodontics to promote the complete root formation in immature permanent teeth with different initial pre-operative conditions. Clin Oral Invest 28, 6 (2024). https://doi.org/10.1007/s00784-023-05403-6

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