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Effect of endodontic treatment on endothelial dysfunction and subclinical atherosclerosis—a prospective intervention study

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Abstract

Objective

The objective of this study is to investigate the effect of endodontic treatment on flow-mediated dilatation (FMD) and carotid intima-media thickness (c-IMT) in patients with apical periodontitis (AP).

Material and method

The study includes 32 young men having AP with a mean age of 25.78 years free from cardiovascular disease (CVD) and its risk factors, including periodontitis. All subjects underwent complete physical and dental examination, echocardiography, and ultrasound assessment of FMD on the brachial artery and c-IMT on the carotid artery at baseline and 12 months after the endodontic treatment. Data were analyzed using paired Student’s t-test and Pearson’s correlation coefficient (r) test using SPSS 26 version.

Results

Endodontic treatment leads to the improvement of FMD significantly from a pooled baseline value of 4.84 ± 1.55% to 7.68 ± 2.08% (p < 0.05). The study also depicts a statistically significant difference between c-IMT (mean = 0.62 ± 0.11 mm) before treatment as compared to 12 months after treatment (mean = 0.59 ± 0.11 mm) (p < 0.05).

Conclusion

Endodontic treatment leads to improved FMD and decreased c-IMT suggesting that treating AP can be help revert the early stages of CVD.

Clinical relevance

AP could be a potential etiological factor of future CVD and should be treated as soon as diagnosed.

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Data Availability

Any additional information regarding the findings can be requested to the corresponding author.

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Authors and Affiliations

  1. Post Graduate Institute of Dental Sciences, Rohtak, Haryana, 124001, India

    Nishant Chauhan, Shweta Mittal & Sanjay Tewari

  2. Post Graduate Institute of Medical Sciences, Rohtak, Haryana, 124001, India

    Jyotsna Sen & Kuldip Laller

Authors
  1. Nishant Chauhan
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  2. Shweta Mittal
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  3. Sanjay Tewari
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  4. Jyotsna Sen
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  5. Kuldip Laller
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Dr. Nishant Chauhan and Dr. Shweta Mittal. The first draft of the manuscript was written by Dr. Sanjay Tewari, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Nishant Chauhan.

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Ethics approval and consent to participate

The study protocol was presented in front of our institutional ethical committee on 13 March 2019 and got approved on 12 April 2019 with the number PGIDS/IEC/2019/7 B. Patients were informed in simple language, and written informed consent was obtained from them in their language.

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The authors declare no competing interests.

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Chauhan, N., Mittal, S., Tewari, S. et al. Effect of endodontic treatment on endothelial dysfunction and subclinical atherosclerosis—a prospective intervention study. Clin Oral Invest 27, 5617–5625 (2023). https://doi.org/10.1007/s00784-023-05183-z

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